A fuel cell is a device that converts the chemical energy from a fuel into electricity through a chemical reaction of positively charged hydrogen ions with oxygen or another oxidizing agent. Fuel cells are different from batteries in that they require a continuous source of fuel and oxygen or air to sustain the chemical reaction, whereas in a battery the chemicals present in the battery react with each other to generate an electromotive force (emf). Fuel cells can produce electricity continuously for as long as these inputs are supplied.

The first fuel cells were invented in 1838. The first commercial use of fuel cells came more than a century later in NASA space programs to generate power for satellites and space capsules. Since then, fuel cells have been used in many other applications. Fuel cells are used for primary and backup power for commercial, industrial and residential buildings and in remote or inaccessible areas. They are also used to power fuel cell vehicles, including forklifts, automobiles, buses, boats, motorcycles and submarines.

Hydrogen fuel is a zero-emission fuel when burned with oxygen (if one considers water not as an emission) or used in a contained cell also capable of 'reversing' the reaction if needed. It often uses electrochemical cells, or combustion in internal engines, to power vehicles and electric devices. It is also used in the propulsion of spacecraft and might potentially be mass-produced and commercialized for passenger vehicles and aircraft.

Hydrogen lies in the first group and first period in the periodic table, i.e. it is the first element on the periodic table, making it the lightest element. Since hydrogen gas is so light, it rises in the atmosphere and is therefore rarely found in its pure form, H₂. In a flame of pure hydrogen gas, burning in air, the hydrogen (H₂) reacts with oxygen (O₂) to form water (H₂O) and releases energy.

(If carried out in atmospheric air instead of pure oxygen (as is usually the case), hydrogen combustion may yield small amounts of nitrogen oxides, along with the water vapor.)