Looking after Bronx patients with genetic problems, using medical genomic information and molecular genomic assays, trying to understand how to bring epigenetics into practical use in medicine.
Get the word out, we need to be testing for this variant in our Black American patients, generating genotype-adjusted HbA1c levels: https://lnkd.in/e89HSsfu
Looking after Bronx patients with genetic problems, using medical genomic information and molecular genomic assays, trying to understand how to bring epigenetics into practical use in medicine.
Wonderful patient, wonderful family, recommended to all who care for an individual with a rare disease Montefiore Health System #NYCRD
Never be afraid to ask for help! If you're raising a child with a rare disease, know that support is available. Join me tonight for a zoom community conversation. Register here: https://lnkd.in/gbsY6Zff
Looking after Bronx patients with genetic problems, using medical genomic information and molecular genomic assays, trying to understand how to bring epigenetics into practical use in medicine.
When your chat with Claude 3.5 from Anthropic is more thoughtful than with colleagues in the field. The question: Is the evidence for trans-generational #epigenetic transmission of trauma reliable? The answer: "The evidence for transgenerational epigenetic transmission of trauma is a topic of ongoing scientific debate. While some studies have suggested such transmission, the reliability and interpretation of this evidence are contested. Here's an overview of the current state of research: 1. Animal studies: Some animal studies, particularly in rodents, have shown evidence of epigenetic changes related to stress being passed down to offspring. However, these studies often involve extreme conditions that may not translate directly to human experiences. 2. Human studies: Human studies on this topic are more limited and often rely on correlational data, which makes it difficult to establish causation. Some of the most cited studies involve descendants of Holocaust survivors or individuals who experienced famine. 3. Methodological concerns: Many studies in this field have been criticized for methodological issues, including small sample sizes, lack of proper controls, and difficulty in isolating epigenetic effects from other factors (e.g., shared environment, cultural transmission). 4. Replication issues: Some high-profile studies suggesting transgenerational epigenetic inheritance have failed to replicate, raising questions about the robustness of the findings. 5. Biological plausibility: There are questions about the biological mechanisms that would allow for such transmission in humans, given that most epigenetic marks are reset during gametogenesis and early embryonic development. 6. Alternative explanations: Critics argue that observed effects might be better explained by other factors, such as sociocultural transmission of trauma or persistent environmental stressors. 7. Emerging research: More recent studies are attempting to address previous limitations, but it's an evolving field with much still to be understood. Given these points, while there is some evidence suggesting the possibility of transgenerational epigenetic transmission of trauma, the reliability of this evidence is still a matter of scientific debate. The scientific community generally agrees that more rigorous, well-controlled studies are needed to draw firm conclusions. It's important to approach this topic with caution and recognize the complexity of separating genetic, epigenetic, and environmental factors in human studies. If you're interested in specific studies or aspects of this research, I'd be happy to discuss further."
Looking after Bronx patients with genetic problems, using medical genomic information and molecular genomic assays, trying to understand how to bring epigenetics into practical use in medicine.
Vile. Rhasidat Adeleke is proudly representing Tallaght and Ireland, her country, where she was born and raised. Ireland needs more Rhasidats and fewer of these snowflake trolls who need to remember how Irish immigrants were treated through history. We were Rhasidat without the talent. Thank you Rhasidat. #ThankYouRhasidat
Rhasidat needs to hear loud and clear that these racists are a tiny minority in Ireland and represent no one only themselves. She needs to hear and know that we are so proud of her as a nation. She is an extraordinarily talented and gifted athlete, and more importantly an inspirational role model to girls and boys here. Go Rhasidat, the country is behind you! https://lnkd.in/eMsbNTz6
Looking after Bronx patients with genetic problems, using medical genomic information and molecular genomic assays, trying to understand how to bring epigenetics into practical use in medicine.
If you are jealous that I’m working here at the Institut Imagine this week, well that was kind of my intention. Getting lots of ideas for things we should be doing at the NY Center for Rare Diseases. #NYCRD #RareDiseases
Looking after Bronx patients with genetic problems, using medical genomic information and molecular genomic assays, trying to understand how to bring epigenetics into practical use in medicine.
Looking forward this week to learning how the Imagine Institute of Genetic Diseases performs diagnostics, care and therapy for patients with rare diseases. Thanks to Arnold Munnich for hosting me. #InstitutImagine #Paris #RareDisease
Looking after Bronx patients with genetic problems, using medical genomic information and molecular genomic assays, trying to understand how to bring epigenetics into practical use in medicine.
A massive accomplishment in Irish athletics
The judgment from Sharlene …The crackle in Greg’s voice…. The Irish fans at the finish line….. That was pure magic and a moment that will never be forgotten 💚 #IrishAthletics #EuropeanChampions #Roma24 123.ie Sport Ireland European Athletics
Looking after Bronx patients with genetic problems, using medical genomic information and molecular genomic assays, trying to understand how to bring epigenetics into practical use in medicine.
Our Pcaso idea from a few years ago always seemed like it had possibilities. Now its killer application could be to resolve the misleading effects of dimension reduction in single cell data visualisation. Nathaniel Pearson has sent out a call to arms. Who might be interested in helping to bring our alpha version of the code to production? Github link to current code https://lnkd.in/eRHiDszE https://lnkd.in/eCNb-GgT Christian Stolte #Pcaso #Dataviz