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Integration of population genetics (GWAS) and single-cell methods (Perturb-seq), and it's amazing!
These approaches can bring computational/statistic results and highly complex biological contexts all together.
Researchers have linked hundreds of genetic variants to coronary artery disease risk, but as with many conditions, probing the biological relationships between variants and risk remains challenging. Gavin Schnitzler, Helen Kang, Rajat Gupta, Jesse Engreitz and colleagues have developed and applied what they call a Variant-to-Gene-to-Program (V2G2P) approach which prioritizes the pathways shared by multiple risk loci. Using CRISPRi-Perturb-seq and machine learning, they found connections between CAD risk and 41 variants in endothelial cells, which line blood vessels. Several of these variants regulate endothelial cells' response to blood flow, and represent new CAD mechanisms. Learn more in Nature: https://lnkd.in/efcmYbNQ.
#BroadInstitute#Science#ScienceNews#Research#ScientificResearch
Gene expression regulation mechanisms
1. Regulation of Transcription Initiation Frequency
2. Regulation of Transcription Elongation
3. Alternative Transcriptional Initiation (ATI)
4. Alternative Splicing (AS)
5. Alternative Polyadenylation (APA)
6. RNA Degradation by RNA Interference (RNAi)
7. Interference of RNAi by Long Noncoding RNA (lncRNA)
8. Translation Initiation Regulation
9. Chromosome Remodeling and Epigenetic Regulation
I'm excited to share that I recently served as a member of the 1st Daily KOSMI Student Press Corps at the 2024 Spring Conference of the Korean Society of Medical Informatics (KOSMI).
As part of this pioneering student journalist team, I had the opportunity to cover cutting-edge developments in medical informatics and get to know leading experts in the field.
This experience not only deepened my understanding of medical informatics but also honed my skills in journalism and professional networking. I'm grateful for the chance to contribute to the dissemination of important research and innovations in healthcare technology.
Looking forward to applying these insights in my future endeavors in the intersection of healthcare and technology!
"Although it may sound like a textbook, there are a few tasks that need to be done together when importing foreign theories and discourses. First, translate the central works that represent such trends. Second, introduce the social and historical background so that the process of how the problem consciousness emerged can be understood. Third, conduct research on intellectual history that reveals the intellectual and practical traditions to which the trend belongs, or at least publish a substantial secondary book together. Fourth, provide a critique of how it connects with the Korean reality and in what context. If only this basic intellectual sincerity had been observed to some extent, the embarrassing situation of importing East German and Soviet textbooks in the midst of the globalizing world of the 1990s could have been avoided. But why wasn't this basic manual followed?"
- Gi-Bin Hong (https://lnkd.in/gT9dn2SD)
"South Korea, having frequently cited Minerva University and even creating a clone named Taejae University, must reflect on whether it has merely chased Minerva's reputation as the "most innovative university in the world" without fully engaging with the profound impact of Minerva's transglobal hybrid higher learning model."
- Kyuseok Kim
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In Korean society, the importation of theories is carried out indiscriminately. The uncritical and decontextualized behavior of intellectuals only turns Korea into a 'theoretical colony.' This inevitably leads to "a bias towards universality that denies the specificity of the country and society in question," and can never solve the problems faced by Korea.
Head of Data Science at GreenLight Biosciences, Inc.
Figeno (FIGure GENerator for GENOmics) is a cool visualization tool for genomics that can generate publication-quality figures. It is straightforward to install on any OS and has support for all types of sequencing data including long-read sequencing along with base modifications, and WGS with CNAs and SVs https://t.co/ln22SewiZ7
Github: https://lnkd.in/em-p9v64
Documentation: https://lnkd.in/epAdiC7M
Youtube video: https://lnkd.in/eRzFsi6w