Sodium voltage-gated channel alpha subunit 8 (Q21135479)

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mammalian protein found in Homo sapiens

• voltage-gated sodium channel subunit alpha Nav1.6
• SCN8A
• sodium channel protein type 8 subunit alpha
• Sodium channel protein type VIII subunit alpha
• sodium channel, voltage gated, type VIII, alpha subunit
• hNa6/Scn8a voltage-gated sodium channel
• voltage-gated sodium channel type VIII alpha protein

edit

Language	Label	Description	Also known as
English	Sodium voltage-gated channel alpha subunit 8	mammalian protein found in Homo sapiens	voltage-gated sodium channel subunit alpha Nav1.6 SCN8A sodium channel protein type 8 subunit alpha Sodium channel protein type VIII subunit alpha sodium channel, voltage gated, type VIII, alpha subunit hNa6/Scn8a voltage-gated sodium channel voltage-gated sodium channel type VIII alpha protein

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UQD0

part of

Voltage gated sodium channel, alpha-8 subunit

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UQD0

Voltage-dependent channel domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UQD0

Voltage gated sodium channel

1 reference

Transporter Classification Database ID

1.A.1.10.8

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

Sodium ion transport-associated domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ion transport domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Voltage-gated Na+ ion channel, cytoplasmic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

IQ motif, EF-hand binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UQD0

encoded by

SCN8A

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UQD0

molecular function

nucleotide binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IEA

sodium channel activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IEA

voltage-gated ion channel activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IEA

ion channel activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IEA

ATP binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IEA

protein binding

determination method

IPI

3 references

retrieved

8 April 2019

stated in

Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IPI

retrieved

8 April 2019

stated in

Identifying a kinase network regulating FGF14:Nav1.6 complex assembly using split-luciferase complementation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IPI

retrieved

8 April 2019

stated in

Bioluminescence methodology for the detection of protein-protein interactions within the voltage-gated sodium channel macromolecular complex

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IPI

voltage-gated sodium channel activity

determination method

IEA

IDA

IMP

NAS

5 references

retrieved

27 February 2018

stated in

Exon organization, coding sequence, physical mapping, and polymorphic intragenic markers for the human neuronal sodium channel gene SCN8A

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQD0&geneProductId=UniProtKB:Q9UQD0

determination method

NAS

retrieved

27 February 2018

stated in

De novo gain-of-function and loss-of-function mutations of SCN8A in patients with intellectual disabilities and epilepsy

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQD0&geneProductId=UniProtKB:Q9UQD0

determination method

IMP

retrieved

27 February 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQD0&geneProductId=UniProtKB:Q9UQD0

determination method

IEA

retrieved

27 February 2018

stated in

Addition of positive charges at the C-terminal peptide region of CssII, a mammalian scorpion peptide toxin, improves its affinity for sodium channels Nav1.6

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQD0&geneProductId=UniProtKB:Q9UQD0

determination method

IDA

retrieved

27 February 2018

stated in

Characterization of a de novo SCN8A mutation in a patient with epileptic encephalopathy

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQD0&geneProductId=UniProtKB:Q9UQD0

determination method

IDA

voltage-gated sodium channel activity

determination method

IBA

IDA

IEA

IMP

NAS

6 references

retrieved

8 April 2019

stated in

Exon organization, coding sequence, physical mapping, and polymorphic intragenic markers for the human neuronal sodium channel gene SCN8A

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

NAS

retrieved

8 April 2019

stated in

De novo gain-of-function and loss-of-function mutations of SCN8A in patients with intellectual disabilities and epilepsy

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IMP

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IEA

retrieved

8 April 2019

stated in

Characterization of a de novo SCN8A mutation in a patient with epileptic encephalopathy

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IDA

retrieved

8 April 2019

stated in

Addition of positive charges at the C-terminal peptide region of CssII, a mammalian scorpion peptide toxin, improves its affinity for sodium channels Nav1.6

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IBA

cell component

voltage-gated sodium channel complex

determination method

IC

IEA

2 references

retrieved

27 February 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQD0&geneProductId=UniProtKB:Q9UQD0

determination method

IEA

retrieved

27 February 2018

stated in

Exon organization, coding sequence, physical mapping, and polymorphic intragenic markers for the human neuronal sodium channel gene SCN8A

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQD0&geneProductId=UniProtKB:Q9UQD0

determination method

IC

integral component of membrane

determination method

TAS

IEA

2 references

retrieved

8 April 2019

stated in

Exon organization, coding sequence, physical mapping, and polymorphic intragenic markers for the human neuronal sodium channel gene SCN8A

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IEA

membrane

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IEA

node of Ranvier

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

ISS

Z discdkac

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

ISS

axon initial segment

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

ISS

cytoplasmic vesicle

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IEA

plasma membrane

determination method

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IBA

voltage-gated sodium channel complex

determination method

IBA

IC

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IEA

retrieved

8 April 2019

stated in

Exon organization, coding sequence, physical mapping, and polymorphic intragenic markers for the human neuronal sodium channel gene SCN8A

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IC

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IBA

axon

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IBA

biological process

membrane depolarization during action potential

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IBA

peripheral nervous system development

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

ISS

sodium ion transport

determination method

NAS

IEA

3 references

retrieved

8 April 2019

stated in

Exon organization, coding sequence, physical mapping, and polymorphic intragenic markers for the human neuronal sodium channel gene SCN8A

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

NAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IEA

regulation of ion transmembrane transport

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IEA

ion transport

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UQD0

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IEA

nervous system development

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

Exon organization, coding sequence, physical mapping, and polymorphic intragenic markers for the human neuronal sodium channel gene SCN8A

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

TAS

ion transmembrane transport

determination method

IEA

1 reference

retrieved

27 February 2018

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQD0&geneProductId=UniProtKB:Q9UQD0

determination method

IEA

transmembrane transport

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IEA

myelination

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

ISS

neuronal action potential

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IBA

sodium ion transmembrane transport

determination method

IEA

1 reference

retrieved

27 February 2018

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UQD0&geneProductId=UniProtKB:Q9UQD0

determination method

IEA

sodium ion transmembrane transport

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UQD0

determination method

IBA

physically interacts with

saxitoxin

has use

channel blocker

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2625

language of work or name

English

retrieved

17 August 2016

exact match

http://purl.uniprot.org/uniprot/Q9UQD0

1 reference

stated in

Identifiers.org

has part(s)

Voltage-gated Na+ ion channel, cytoplasmic domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UQD0

Ion transport domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UQD0

IQ motif, EF-hand binding site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UQD0

Sodium ion transport-associated

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UQD0

Identifiers

MeSH descriptor ID

D062557

0 references

RefSeq protein ID

NP_001171455

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

6334

NP_001317189

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

6334

NP_055006

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

6334

NP_001356717

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

6334

UniProt protein ID

Q9UQD0

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UQD0

Ensembl protein ID

ENSP00000346534

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000346534

ENSP00000347255

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000347255

ENSP00000440360

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000440360

ENSP00000476447

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000476447

ENSP00000487583

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000487583

ENSP00000447567

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000447567

ENSP00000486828

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000486828

ENSP00000490470

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000490470

ENSP00000490580

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000490580

ENSP00000492157

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000492157

ENSP00000499511

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000499511

ENSP00000499724

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000499724

ENSP00000499636

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000499636

ENSP00000499691

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000499691

PDB structure ID

3WFN

1 reference

stated in

Swiss-Prot

UniProt

retrieved

10 November 2015

reference URL

http://www.uniprot.org/uniprot/Q9WTU3.txt?version=127

Transporter Classification Database ID

1.A.1.10.8

2 references

stated in

Transporter Classification database

retrieved

13 March 2020

stated in

Transporter Classification database

retrieved

29 April 2020

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q21135479&oldid=2023025305"