Tektin-1

TEKT1
Identifiers
Aliases	TEKT1, tektin 1
External IDs	OMIM: 609002; MGI: 1333819; HomoloGene: 7973; GeneCards: TEKT1; OMA:TEKT1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	6,831,761 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	72,253,268 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; right uterine tube; ; olfactory zone of nasal mucosa; ; mucosa of paranasal sinus; ; left testis; ; right testis; ; sperm; ; epithelium of nasopharynx; ; testicle; ; nasal epithelium;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; utricle; ; olfactory epithelium; ; morula; ; vestibular sensory epithelium; ; Epithelium of choroid plexus; ; right lung lobe; ; choroid plexus of fourth ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; microtubule cytoskeleton; cell projection; cilium; microtubule; cytoskeleton; nucleus; sperm flagellum; motile cilium;
Biological process	flagellated sperm motility; cilium assembly; cilium movement involved in cell motility;
	Sources:Amigo / QuickGO
Orthologs
	83659
	21689
	ENSG00000167858
	ENSMUSG00000020799
	Q969V4
	Q9DAJ2
	NM_053285
	NM_001282006; NM_001282007; NM_011569
	NP_444515
	NP_001268935; NP_001268936; NP_035699
	Wikidata
View/Edit Human	View/Edit Mouse

Tektin-1 is a protein that in humans is encoded by the TEKT1 gene.^[5]^[6]

Function

This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may play a role in spermatogenesis.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167858 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020799 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: tektin 1".
^ Xu M, Zhou Z, Cheng C, Zhao W, Tang R, Huang Y, Wang W, Xu J, Zeng L, Xie Y, Mao Y (December 2001). "Cloning and characterization of a novel human TEKTIN1 gene". Int. J. Biochem. Cell Biol. 33 (12): 1172–82. doi:10.1016/S1357-2725(01)00089-9. PMID 11606253.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Newby PR, Pickles OJ, Mazumdar S, et al. (2010). "Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study". Eur. J. Hum. Genet. 18 (9): 1021–6. doi:10.1038/ejhg.2010.55. PMC 2987410. PMID 20442750.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Iguchi N, Tanaka H, Nakamura Y, et al. (2002). "Cloning and characterization of the human tektin-t gene". Mol. Hum. Reprod. 8 (6): 525–30. doi:10.1093/molehr/8.6.525. PMID 12029069.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167858 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020799 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: tektin 1".

[pmid11606253-6] Xu M, Zhou Z, Cheng C, Zhao W, Tang R, Huang Y, Wang W, Xu J, Zeng L, Xie Y, Mao Y (December 2001). "Cloning and characterization of a novel human TEKTIN1 gene". Int. J. Biochem. Cell Biol. 33 (12): 1172–82. doi:10.1016/S1357-2725(01)00089-9. PMID 11606253.

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Function

References

Further reading