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{{Short description|Protein found in humans}} |
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{{Infobox_gene}} |
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'''Metallothionein-2''' is a [[protein]] that in humans is encoded by the ''MT2A'' [[gene]].<ref name="pmid7133118">{{cite journal | |
'''Metallothionein-2''' is a [[metallothionein]] [[protein]] that in humans is encoded by the ''MT2A'' [[gene]].<ref name="pmid7133118">{{cite journal |vauthors=Karin M, Richards RI | title = Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene | journal = Nature | volume = 299 | issue = 5886 | pages = 797–802 |date=Dec 1982 | pmid = 7133118 | doi =10.1038/299797a0 | bibcode =1982Natur.299..797K | s2cid = 4332683 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MT2A metallothionein 2A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4502}}</ref> |
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The [[single-nucleotide polymorphism]] rs28366003 which substitutes [[guanine]] for [[adenine]] in ''MT2A'' is associated with certain [[cancer]]s and some [[Chronic condition|chronic diseases]].<ref name="pmid32597135">{{cite journal | vauthors=Sekovanić A, Jurasović J, Piasek M | title=Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans | journal=Arhiv Za Higijenu Rada I Toksikologiju | volume=71 | issue=1 | pages=27–47 | year=2020 | doi = 10.2478/aiht-2020-71-3349 | pmc=7837243 | pmid=32597135 }}</ref> |
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==Interactions== |
==Interactions== |
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Metallothionein 2A has been shown to [[ |
Metallothionein 2A has been shown to [[protein-protein interaction|interact]] with [[protein kinase D1]].<ref name=pmid14550308>{{cite journal |doi=10.1016/j.bbrc.2003.09.118 |last=Rao |first=Prema S |author2=Jaggi Meena |author3=Smith David J |author4=Hemstreet George P |author5=Balaji K C |date=Oct 2003 |title=Metallothionein 2A interacts with the kinase domain of PKCmu in prostate cancer |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue=3 |pages=1032–8 |location = United States| issn = 0006-291X| pmid = 14550308 }}</ref> |
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==References== |
==References== |
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{{reflist}} |
{{reflist}} |
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==Further reading== |
==Further reading== |
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{{refbegin | 2}} |
{{refbegin | 2}} |
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*{{cite journal |vauthors=Kissling MM, Kägi HR |title=Primary structure of human hepatic metallothionein. |journal=FEBS Lett. |volume=82 |issue= 2 |pages= 247–50 |year= 1977 |pmid= 913597 |doi=10.1016/0014-5793(77)80594-2 |s2cid=46396323 |doi-access=free |bibcode=1977FEBSL..82..247K }} |
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{{PBB_Further_reading |
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*{{cite journal |vauthors=Yamazaki S, Nakanishi M, Hamamoto T, etal |title=Expression of human metallothionein-II fusion protein in Escherichia coli. |journal=Biochem. Int. |volume=28 |issue= 3 |pages= 451–60 |year= 1993 |pmid= 1339282 }} |
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| citations = |
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*{{cite journal |
*{{cite journal |vauthors=Messerle BA, Schäffer A, Vasák M, etal |title=Comparison of the solution conformations of human [Zn7]-metallothionein-2 and [Cd7]-metallothionein-2 using nuclear magnetic resonance spectroscopy. |journal=J. Mol. Biol. |volume=225 |issue= 2 |pages= 433–43 |year= 1992 |pmid= 1593628 |doi=10.1016/0022-2836(92)90930-I }} |
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*{{cite journal |
*{{cite journal |vauthors=Zafarullah M, Martel-Pelletier J, Cloutier JM, etal |title=Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte. |journal=FEBS Lett. |volume=306 |issue= 2–3 |pages= 169–72 |year= 1992 |pmid= 1633872 |doi=10.1016/0014-5793(92)80992-P |s2cid=43460076 |doi-access=free |bibcode=1992FEBSL.306..169Z }} |
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*{{cite journal |
*{{cite journal |vauthors=Messerle BA, Schäffer A, Vasák M, etal |title=Three-dimensional structure of human [113Cd7]metallothionein-2 in solution determined by nuclear magnetic resonance spectroscopy. |journal=J. Mol. Biol. |volume=214 |issue= 3 |pages= 765–79 |year= 1990 |pmid= 2388267 |doi=10.1016/0022-2836(90)90291-S }} |
||
*{{cite journal | |
*{{cite journal |vauthors=Duguid JR, Bohmont CW, Liu NG, Tourtellotte WW |title=Changes in brain gene expression shared by scrapie and Alzheimer disease. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 18 |pages= 7260–4 |year= 1989 |pmid= 2780570 |doi=10.1073/pnas.86.18.7260 | pmc=298037 |bibcode=1989PNAS...86.7260D |doi-access=free }} |
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*{{cite journal |
*{{cite journal |vauthors=Karin M, Haslinger A, Heguy A, etal |title=Metal-responsive elements act as positive modulators of human metallothionein-IIA enhancer activity. |journal=Mol. Cell. Biol. |volume=7 |issue= 2 |pages= 606–13 |year= 1987 |pmid= 3821726 |doi= 10.1128/mcb.7.2.606| pmc=365115 }} |
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*{{cite journal |
*{{cite journal |vauthors=Karin M, Haslinger A, Holtgreve H, etal |title=Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene. |journal=Nature |volume=308 |issue= 5959 |pages= 513–9 |year= 1984 |pmid= 6323998 |doi=10.1038/308513a0 |bibcode=1984Natur.308..513K |s2cid=4357363 }} |
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*{{cite journal | |
*{{cite journal |vauthors=Schmidt CJ, Hamer DH, McBride OW |title=Chromosomal location of human metallothionein genes: implications for Menkes' disease. |journal=Science |volume=224 |issue= 4653 |pages= 1104–6 |year= 1984 |pmid= 6719135 |doi=10.1126/science.6719135 |bibcode=1984Sci...224.1104S }} |
||
*{{cite journal | |
*{{cite journal |vauthors=Karin M, Richards RI |title=Human metallothionein genes: molecular cloning and sequence analysis of the mRNA. |journal=Nucleic Acids Res. |volume=10 |issue= 10 |pages= 3165–73 |year= 1982 |pmid= 6896577 |doi=10.1093/nar/10.10.3165 | pmc=320698 }} |
||
*{{cite journal | |
*{{cite journal |vauthors=Lambert E, Kille P, Swaminathan R |title=Cloning and sequencing a novel metallothionein I isoform expressed in human reticulocytes. |journal=FEBS Lett. |volume=389 |issue= 2 |pages= 210–2 |year= 1996 |pmid= 8766831 |doi=10.1016/0014-5793(96)00587-X |s2cid=8195335 |doi-access=free |bibcode=1996FEBSL.389..210L }} |
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*{{cite journal | |
*{{cite journal |vauthors=Woo ES, Dellapiazza D, Wang AS, Lazo JS |title=Energy-dependent nuclear binding dictates metallothionein localization. |journal=J. Cell. Physiol. |volume=182 |issue= 1 |pages= 69–76 |year= 1999 |pmid= 10567918 |doi= 10.1002/(SICI)1097-4652(200001)182:1<69::AID-JCP8>3.0.CO;2-9 |s2cid=31787611 }} |
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*{{cite journal | |
*{{cite journal |vauthors=Jiang LJ, Vasák M, Vallee BL, Maret W |title=Zinc transfer potentials of the alpha - and beta-clusters of metallothionein are affected by domain interactions in the whole molecule. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 6 |pages= 2503–8 |year= 2000 |pmid= 10716985 |doi=10.1073/pnas.97.6.2503 | pmc=15958 |bibcode=2000PNAS...97.2503J |doi-access=free }} |
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*{{cite journal |
*{{cite journal |vauthors=Garrett SH, Sens MA, Shukla D, etal |title=Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer. |journal=Prostate |volume=43 |issue= 2 |pages= 125–35 |year= 2000 |pmid= 10754528 |doi=10.1002/(SICI)1097-0045(20000501)43:2<125::AID-PROS7>3.0.CO;2-S |s2cid=8768274 }} |
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*{{cite journal |
*{{cite journal |vauthors=Ebert MP, Günther T, Hoffmann J, etal |title=Expression of metallothionein II in intestinal metaplasia, dysplasia, and gastric cancer. |journal=Cancer Res. |volume=60 |issue= 7 |pages= 1995–2001 |year= 2000 |pmid= 10766190 }} |
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*{{cite journal | |
*{{cite journal |vauthors=Toyama M, Yamashita M, Hirayama N, Murooka Y |title=Interactions of arsenic with human metallothionein-2. |journal=J. Biochem. |volume=132 |issue= 2 |pages= 217–21 |year= 2003 |pmid= 12153718 |doi= 10.1093/oxfordjournals.jbchem.a003213}} |
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*{{cite journal | |
*{{cite journal |vauthors=Sun X, Kang YJ |title=Prior increase in metallothionein levels is required to prevent doxorubicin cardiotoxicity. |journal=Exp. Biol. Med. (Maywood) |volume=227 |issue= 8 |pages= 652–7 |year= 2002 |pmid= 12192109 |doi= 10.1177/153537020222700815|s2cid=45099558 }} |
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*{{cite journal |
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} |
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*{{cite journal |
*{{cite journal |vauthors=Izmailova E, Bertley FM, Huang Q, etal |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191–7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822 |s2cid=26145639 }} |
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*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} |
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*{{cite journal | author=Izmailova E, Bertley FM, Huang Q, ''et al.'' |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191–7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822 }} |
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}} |
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{{refend}} |
{{refend}} |
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{{PDB Gallery|geneid=4502}} |
{{PDB Gallery|geneid=4502}} |
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[[Category:Human proteins]] |
[[Category:Human proteins]] |
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{{gene-16-stub}} |
{{gene-16-stub}} |
Latest revision as of 02:41, 6 May 2024
Metallothionein-2 is a metallothionein protein that in humans is encoded by the MT2A gene.[3][4]
The single-nucleotide polymorphism rs28366003 which substitutes guanine for adenine in MT2A is associated with certain cancers and some chronic diseases.[5]
Interactions
[edit]Metallothionein 2A has been shown to interact with protein kinase D1.[6]
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000125148 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Karin M, Richards RI (Dec 1982). "Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene". Nature. 299 (5886): 797–802. Bibcode:1982Natur.299..797K. doi:10.1038/299797a0. PMID 7133118. S2CID 4332683.
- ^ "Entrez Gene: MT2A metallothionein 2A".
- ^ Sekovanić A, Jurasović J, Piasek M (2020). "Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans". Arhiv Za Higijenu Rada I Toksikologiju. 71 (1): 27–47. doi:10.2478/aiht-2020-71-3349. PMC 7837243. PMID 32597135.
- ^ Rao, Prema S; Jaggi Meena; Smith David J; Hemstreet George P; Balaji K C (Oct 2003). "Metallothionein 2A interacts with the kinase domain of PKCmu in prostate cancer". Biochem. Biophys. Res. Commun. 310 (3). United States: 1032–8. doi:10.1016/j.bbrc.2003.09.118. ISSN 0006-291X. PMID 14550308.
Further reading
[edit]- Kissling MM, Kägi HR (1977). "Primary structure of human hepatic metallothionein". FEBS Lett. 82 (2): 247–50. Bibcode:1977FEBSL..82..247K. doi:10.1016/0014-5793(77)80594-2. PMID 913597. S2CID 46396323.
- Yamazaki S, Nakanishi M, Hamamoto T, et al. (1993). "Expression of human metallothionein-II fusion protein in Escherichia coli". Biochem. Int. 28 (3): 451–60. PMID 1339282.
- Messerle BA, Schäffer A, Vasák M, et al. (1992). "Comparison of the solution conformations of human [Zn7]-metallothionein-2 and [Cd7]-metallothionein-2 using nuclear magnetic resonance spectroscopy". J. Mol. Biol. 225 (2): 433–43. doi:10.1016/0022-2836(92)90930-I. PMID 1593628.
- Zafarullah M, Martel-Pelletier J, Cloutier JM, et al. (1992). "Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte". FEBS Lett. 306 (2–3): 169–72. Bibcode:1992FEBSL.306..169Z. doi:10.1016/0014-5793(92)80992-P. PMID 1633872. S2CID 43460076.
- Messerle BA, Schäffer A, Vasák M, et al. (1990). "Three-dimensional structure of human [113Cd7]metallothionein-2 in solution determined by nuclear magnetic resonance spectroscopy". J. Mol. Biol. 214 (3): 765–79. doi:10.1016/0022-2836(90)90291-S. PMID 2388267.
- Duguid JR, Bohmont CW, Liu NG, Tourtellotte WW (1989). "Changes in brain gene expression shared by scrapie and Alzheimer disease". Proc. Natl. Acad. Sci. U.S.A. 86 (18): 7260–4. Bibcode:1989PNAS...86.7260D. doi:10.1073/pnas.86.18.7260. PMC 298037. PMID 2780570.
- Karin M, Haslinger A, Heguy A, et al. (1987). "Metal-responsive elements act as positive modulators of human metallothionein-IIA enhancer activity". Mol. Cell. Biol. 7 (2): 606–13. doi:10.1128/mcb.7.2.606. PMC 365115. PMID 3821726.
- Karin M, Haslinger A, Holtgreve H, et al. (1984). "Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene". Nature. 308 (5959): 513–9. Bibcode:1984Natur.308..513K. doi:10.1038/308513a0. PMID 6323998. S2CID 4357363.
- Schmidt CJ, Hamer DH, McBride OW (1984). "Chromosomal location of human metallothionein genes: implications for Menkes' disease". Science. 224 (4653): 1104–6. Bibcode:1984Sci...224.1104S. doi:10.1126/science.6719135. PMID 6719135.
- Karin M, Richards RI (1982). "Human metallothionein genes: molecular cloning and sequence analysis of the mRNA". Nucleic Acids Res. 10 (10): 3165–73. doi:10.1093/nar/10.10.3165. PMC 320698. PMID 6896577.
- Lambert E, Kille P, Swaminathan R (1996). "Cloning and sequencing a novel metallothionein I isoform expressed in human reticulocytes". FEBS Lett. 389 (2): 210–2. Bibcode:1996FEBSL.389..210L. doi:10.1016/0014-5793(96)00587-X. PMID 8766831. S2CID 8195335.
- Woo ES, Dellapiazza D, Wang AS, Lazo JS (1999). "Energy-dependent nuclear binding dictates metallothionein localization". J. Cell. Physiol. 182 (1): 69–76. doi:10.1002/(SICI)1097-4652(200001)182:1<69::AID-JCP8>3.0.CO;2-9. PMID 10567918. S2CID 31787611.
- Jiang LJ, Vasák M, Vallee BL, Maret W (2000). "Zinc transfer potentials of the alpha - and beta-clusters of metallothionein are affected by domain interactions in the whole molecule". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2503–8. Bibcode:2000PNAS...97.2503J. doi:10.1073/pnas.97.6.2503. PMC 15958. PMID 10716985.
- Garrett SH, Sens MA, Shukla D, et al. (2000). "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer". Prostate. 43 (2): 125–35. doi:10.1002/(SICI)1097-0045(20000501)43:2<125::AID-PROS7>3.0.CO;2-S. PMID 10754528. S2CID 8768274.
- Ebert MP, Günther T, Hoffmann J, et al. (2000). "Expression of metallothionein II in intestinal metaplasia, dysplasia, and gastric cancer". Cancer Res. 60 (7): 1995–2001. PMID 10766190.
- Toyama M, Yamashita M, Hirayama N, Murooka Y (2003). "Interactions of arsenic with human metallothionein-2". J. Biochem. 132 (2): 217–21. doi:10.1093/oxfordjournals.jbchem.a003213. PMID 12153718.
- Sun X, Kang YJ (2002). "Prior increase in metallothionein levels is required to prevent doxorubicin cardiotoxicity". Exp. Biol. Med. (Maywood). 227 (8): 652–7. doi:10.1177/153537020222700815. PMID 12192109. S2CID 45099558.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.