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{{PBB|geneid=5349}}
{{PBB|geneid=5349}}
'''FXYD domain-containing ion transport regulator 3''' is a [[protein]] that in humans is encoded by the ''FXYD3'' [[gene]].<ref name="pmid7836447">{{cite journal | author = Morrison BW, Moorman JR, Kowdley GC, Kobayashi YM, Jones LR, Leder P | title = Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes | journal = J Biol Chem | volume = 270 | issue = 5 | pages = 2176–82 |date=Mar 1995 | pmid = 7836447 | pmc = | doi =10.1074/jbc.270.5.2176 }}</ref><ref name="pmid10950925">{{cite journal | author = Sweadner KJ, Rael E | title = The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression | journal = Genomics | volume = 68 | issue = 1 | pages = 41–56 |date=Sep 2000 | pmid = 10950925 | pmc = | doi = 10.1006/geno.2000.6274 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FXYD3 FXYD domain containing ion transport regulator 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5349| accessdate = }}</ref>
'''FXYD domain-containing ion transport regulator 3''' is a [[protein]] that in humans is encoded by the ''FXYD3'' [[gene]].<ref name="pmid7836447">{{cite journal | vauthors = Morrison BW, Moorman JR, Kowdley GC, Kobayashi YM, Jones LR, Leder P | title = Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes | journal = The Journal of Biological Chemistry | volume = 270 | issue = 5 | pages = 2176–82 | date = Feb 1995 | pmid = 7836447 | pmc = | doi = 10.1074/jbc.270.5.2176 }}</ref><ref name="pmid10950925">{{cite journal | vauthors = Sweadner KJ, Rael E | title = The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression | journal = Genomics | volume = 68 | issue = 1 | pages = 41–56 | date = Aug 2000 | pmid = 10950925 | pmc = | doi = 10.1006/geno.2000.6274 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FXYD3 FXYD domain containing ion transport regulator 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5349| accessdate = }}</ref>


== Function ==
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->

{{PBB_Summary
⚫
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene may function as a chloride channel or as a chloride channel regulator. Two transcript variants encode two different isoforms of the protein; in addition, transcripts utilizing alternative polyA signals have been described in the literature.<ref name="entrez" />
| section_title =
⚫
| summary_text = This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene may function as a chloride channel or as a chloride channel regulator. Two transcript variants encode two different isoforms of the protein; in addition, transcripts utilizing alternative polyA signals have been described in the literature.<ref name="entrez" />
⚫
}}


==Model organisms==
==Model organisms==
[[Model organism]]s have been used in the study of FXYD3 function. A conditional [[knockout mouse]] line called ''Fxyd3<sup>tm1a(KOMP)Wtsi</sup>'' was generated at the [[Wellcome Trust Sanger Institute]].<ref name="mgp_reference">{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |journal=Acta Opthalmologica|volume=88 |pages=925–7|doi=10.1111/j.1755-3768.2010.4142.x }}</ref> Male and female animals underwent a standardized [[phenotypic screen]]<ref name="IMPCsearch_ref">{{cite web |url=http://www.mousephenotype.org/data/search?q=Fxyd3#fq=*:*&facet=gene |title=International Mouse Phenotyping Consortium}}</ref> to determine the effects of deletion.<ref name="pmid21677750">{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref><ref name="pmid23870131">{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, ((Sanger Institute Mouse Genetics Project)), Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | year = 2013 | pmid = 23870131 | doi = 10.1016/j.cell.2013.06.022 | pmc=3717207}}</ref> Additional screens performed: - In-depth immunological phenotyping<ref name="iii_ref">{{cite web |url= http://www.immunophenotyping.org/data/search?keys=Fxyd3&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}</ref>
[[Model organism]]s have been used in the study of FXYD3 function. A conditional [[knockout mouse]] line called ''Fxyd3<sup>tm1a(KOMP)Wtsi</sup>'' was generated at the [[Wellcome Trust Sanger Institute]].<ref name="mgp_reference">{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |journal=Acta Opthalmologica|volume=88 |pages=925–7|doi=10.1111/j.1755-3768.2010.4142.x }}</ref> Male and female animals underwent a standardized [[phenotypic screen]]<ref name="IMPCsearch_ref">{{cite web |url=http://www.mousephenotype.org/data/search?q=Fxyd3#fq=*:*&facet=gene |title=International Mouse Phenotyping Consortium}}</ref> to determine the effects of deletion.<ref name="pmid21677750">{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref><ref name="pmid23870131">{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | date = Jul 2013 | pmid = 23870131 | pmc = 3717207 | doi = 10.1016/j.cell.2013.06.022 }}</ref> Additional screens performed: - In-depth immunological phenotyping<ref name="iii_ref">{{cite web |url= http://www.immunophenotyping.org/data/search?keys=Fxyd3&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}</ref>
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==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Crowell KJ, Franzin CM, Koltay A, Lee S, Lucchese AM, Snyder BC, Marassi FM | title = Expression and characterization of the FXYD ion transport regulators for NMR structural studies in lipid micelles and lipid bilayers | journal = Biochimica et Biophysica Acta | volume = 1645 | issue = 1 | pages = 15–21 | date = Jan 2003 | pmid = 12535606 | pmc = 2917601 | doi = 10.1016/S1570-9639(02)00473-9 }}
{{PBB_Further_reading
* {{cite journal | vauthors = Grzmil M, Voigt S, Thelen P, Hemmerlein B, Helmke K, Burfeind P | title = Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells | journal = International Journal of Oncology | volume = 24 | issue = 1 | pages = 97–105 | date = Jan 2004 | pmid = 14654946 | doi = 10.3892/ijo.24.1.97 }}
| citations =
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
* {{cite journal | vauthors = Kayed H, Kleeff J, Kolb A, Ketterer K, Keleg S, Felix K, Giese T, Penzel R, Zentgraf H, Büchler MW, Korc M, Friess H | title = FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth | journal = International Journal of Cancer. Journal International Du Cancer | volume = 118 | issue = 1 | pages = 43–54 | date = Jan 2006 | pmid = 16003754 | doi = 10.1002/ijc.21257 }}
*{{cite journal | author=Crowell KJ, Franzin CM, Koltay A |title=Expression and characterization of the FXYD ion transport regulators for NMR structural studies in lipid micelles and lipid bilayers |journal=Biochim. Biophys. Acta |volume=1645 |issue= 1 |pages= 15–21 |year= 2003 |pmid= 12535606 | pmc=2917601 |doi= 10.1016/S1570-9639(02)00473-9|display-authors=etal}}
* {{cite journal | vauthors = Franzin CM, Yu J, Thai K, Choi J, Marassi FM | title = Correlation of gene and protein structures in the FXYD family proteins | journal = Journal of Molecular Biology | volume = 354 | issue = 4 | pages = 743–50 | date = Dec 2005 | pmid = 16288923 | pmc = 2907130 | doi = 10.1016/j.jmb.2005.10.018 }}
*{{cite journal | author=Grzmil M, Voigt S, Thelen P |title=Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells |journal=Int. J. Oncol. |volume=24 |issue= 1 |pages= 97–105 |year= 2004 |pmid= 14654946 |doi= 10.3892/ijo.24.1.97|display-authors=etal}}
* {{cite journal | vauthors = Bibert S, Roy S, Schaer D, Felley-Bosco E, Geering K | title = Structural and functional properties of two human FXYD3 (Mat-8) isoforms | journal = The Journal of Biological Chemistry | volume = 281 | issue = 51 | pages = 39142–51 | date = Dec 2006 | pmid = 17077088 | doi = 10.1074/jbc.M605221200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
* {{cite journal | vauthors = Arimochi J, Ohashi-Kobayashi A, Maeda M | title = Interaction of Mat-8 (FXYD-3) with Na+/K+-ATPase in colorectal cancer cells | journal = Biological & Pharmaceutical Bulletin | volume = 30 | issue = 4 | pages = 648–54 | date = Apr 2007 | pmid = 17409496 | doi = 10.1248/bpb.30.648 }}
*{{cite journal | author=Kayed H, Kleeff J, Kolb A |title=FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth |journal=Int. J. Cancer |volume=118 |issue= 1 |pages= 43–54 |year= 2005 |pmid= 16003754 |doi= 10.1002/ijc.21257 |display-authors=etal}}
*{{cite journal | author=Franzin CM, Yu J, Thai K |title=Correlation of gene and protein structures in the FXYD family proteins |journal=J. Mol. Biol. |volume=354 |issue= 4 |pages= 743–50 |year= 2006 |pmid= 16288923 | pmc=2907130 |doi= 10.1016/j.jmb.2005.10.018 |display-authors=etal}}
*{{cite journal | author=Bibert S, Roy S, Schaer D |title=Structural and functional properties of two human FXYD3 (Mat-8) isoforms |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39142–51 |year= 2007 |pmid= 17077088 |doi= 10.1074/jbc.M605221200 |display-authors=etal}}
*{{cite journal | author=Arimochi J, Ohashi-Kobayashi A, Maeda M |title=Interaction of Mat-8 (FXYD-3) with Na+/K+-ATPase in colorectal cancer cells |journal=Biol. Pharm. Bull. |volume=30 |issue= 4 |pages= 648–54 |year= 2007 |pmid= 17409496 |doi=10.1248/bpb.30.648 }}
}}
{{refend}}
{{refend}}

<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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{{gene-19-stub}}
{{gene-19-stub}}

Revision as of 15:04, 9 January 2016

Template:PBB FXYD domain-containing ion transport regulator 3 is a protein that in humans is encoded by the FXYD3 gene.[1][2][3]

Function

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene may function as a chloride channel or as a chloride channel regulator. Two transcript variants encode two different isoforms of the protein; in addition, transcripts utilizing alternative polyA signals have been described in the literature.[3]

Model organisms

Model organisms have been used in the study of FXYD3 function. A conditional knockout mouse line called Fxyd3tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[4] Male and female animals underwent a standardized phenotypic screen[5] to determine the effects of deletion.[6][7][8][9] Additional screens performed: - In-depth immunological phenotyping[10]

References

  1. ^ Morrison BW, Moorman JR, Kowdley GC, Kobayashi YM, Jones LR, Leder P (Feb 1995). "Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes". The Journal of Biological Chemistry. 270 (5): 2176–82. doi:10.1074/jbc.270.5.2176. PMID 7836447.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  2. ^ Sweadner KJ, Rael E (Aug 2000). "The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression". Genomics. 68 (1): 41–56. doi:10.1006/geno.2000.6274. PMID 10950925.
  3. ^ a b "Entrez Gene: FXYD3 FXYD domain containing ion transport regulator 3".
  4. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  5. ^ a b "International Mouse Phenotyping Consortium".
  6. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  7. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  8. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  9. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  10. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading

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