POLE4

POLE4
Identifiers
Aliases	POLE4, YHHQ1, p12, polymerase (DNA) epsilon 4, accessory subunit, DNA polymerase epsilon 4, accessory subunit
External IDs	OMIM: 607269; MGI: 1914229; HomoloGene: 41339; GeneCards: POLE4; OMA:POLE4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	74,970,128 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	82,682,346 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; cingulate gyrus; ; anterior cingulate cortex; ; mucosa of transverse colon; ; right adrenal cortex; ; popliteal artery; ; tibial arteries; ; monocyte; ; left adrenal gland; ; gastrocnemius muscle;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; yolk sac; ; retinal pigment epithelium; ; ciliary body; ; right kidney; ; ventricular zone; ; embryo; ; iris;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; DNA binding; DNA-directed DNA polymerase activity; nucleotidyltransferase activity; protein binding; protein heterodimerization activity;
Cellular component	epsilon DNA polymerase complex; nucleus; nucleoplasm;
Biological process	histone H3 acetylation; DNA biosynthetic process; G1/S transition of mitotic cell cycle; DNA replication initiation; telomere maintenance via semi-conservative replication;
	Sources:Amigo / QuickGO
Orthologs
	56655
	66979
	ENSG00000115350
	ENSMUSG00000030042
	Q9NR33
	Q9CQ36
	NM_019896
	NM_025882; NM_001370295
	NP_063949
	NP_080158; NP_001357224
	Wikidata
View/Edit Human	View/Edit Mouse

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Polymerase (DNA-directed), epsilon 4, accessory subunit is a protein that in humans is encoded by the POLE4 gene.^[5]

Function

POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115350 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030042 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Polymerase (DNA-directed), epsilon 4, accessory subunit".

Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon". Nucleic Acids Res. 31 (19): 5568–75. doi:10.1093/nar/gkg765. PMC 206465. PMID 14500819.
Li Y, Pursell ZF, Linn S (2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J. Biol. Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.
Wang YL, Faiola F, Xu M, Pan S, Martinez E (2008). "Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein". J. Biol. Chem. 283 (49): 33808–15. doi:10.1074/jbc.M806936200. PMC 2590711. PMID 18838386.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115350 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030042 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Polymerase (DNA-directed), epsilon 4, accessory subunit".

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Function

References

Further reading