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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{PBB|geneid=26574}}
{{Infobox_gene}}
'''Protein AATF''' is a [[protein]] that in humans is encoded by the ''AATF'' [[gene]].<ref name="pmid11027528">{{cite journal | author = Lindfors K, Halttunen T, Huotari P, Nupponen N, Vihinen M, Visakorpi T, Maki M, Kainulainen H | title = Identification of novel transcription factor-like gene from human intestinal cells | journal = Biochem Biophys Res Commun | volume = 276 | issue = 2 | pages = 660–6 | year = 2000 | month = Oct | pmid = 11027528 | pmc = | doi = 10.1006/bbrc.2000.3480 }}</ref><ref name="pmid10783144">{{cite journal | author = Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C | title = Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb | journal = FASEB J | volume = 14 | issue = 7 | pages = 904–12 | year = 2000 | month = Jun | pmid = 10783144 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AATF apoptosis antagonizing transcription factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26574| accessdate = }}</ref>
'''Protein AATF''', also known as '''apoptosis-antagonizing transcription factor''' is a [[protein]] that in humans is encoded by the ''AATF'' [[gene]].<ref name="pmid11027528">{{cite journal | vauthors = Lindfors K, Halttunen T, Huotari P, Nupponen N, Vihinen M, Visakorpi T, Mäki M, Kainulainen H | title = Identification of novel transcription factor-like gene from human intestinal cells | journal = Biochemical and Biophysical Research Communications | volume = 276 | issue = 2 | pages = 660–6 | date = Sep 2000 | pmid = 11027528 | doi = 10.1006/bbrc.2000.3480 }}</ref><ref name="pmid10783144">{{cite journal | vauthors = Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C | title = Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb | journal = FASEB Journal | volume = 14 | issue = 7 | pages = 904–12 | date = May 2000 | pmid = 10783144 | doi = 10.1096/fasebj.14.7.904| doi-access = free | s2cid = 43175069 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AATF apoptosis antagonizing transcription factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26574}}</ref>


== Function ==
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
⚫
| summary_text = The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.<ref name="entrez"/>
}}


⚫
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.<ref name="entrez"/>
==Interactions==
Apoptosis antagonizing transcription factor has been shown to [[Protein-protein interaction|interact]] with [[Sp1 transcription factor]],<ref name=pmid12847090>{{cite journal |last=Di Padova |first=Monica |authorlink= |coauthors=Bruno Tiziana, De Nicola Francesca, Iezzi Simona, D'Angelo Carmen, Gallo Rita, Nicosia Daniela, Corbi Nicoletta, Biroccio Annamaria, Floridi Aristide, Passananti Claudio, Fanciulli Maurizio |year=[[2003]]|month=Sep. |title=Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter |journal=J. Biol. Chem. |volume=278 |issue=38 |pages=36496–504 |publisher= |location = United States| issn = 0021-9258| pmid = 12847090 |doi = 10.1074/jbc.M306694200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[POLR2J]],<ref name=pmid10783144>{{cite journal |last=Fanciulli |first=M |authorlink= |coauthors=Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C |year=[[2000]]|month=May. |title=Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb |journal=FASEB J. |volume=14 |issue=7 |pages=904–12 |publisher= |location = UNITED STATES| issn = 0892-6638| pmid = 10783144 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[PAWR]]<ref name=pmid14627703>{{cite journal |last=Guo |first=Qing |authorlink= |coauthors=Xie Jun |year=[[2004]]|month=Feb. |title=AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4 |journal=J. Biol. Chem. |volume=279 |issue=6 |pages=4596–603 |publisher= |location = United States| issn = 0021-9258| pmid = 14627703 |doi = 10.1074/jbc.M309811200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[Retinoblastoma protein]].<ref name=pmid10783144/><ref name=pmid12450794>{{cite journal |last=Bruno |first=Tiziana |authorlink= |coauthors=De Angelis Roberta, De Nicola Francesca, Barbato Christian, Di Padova Monica, Corbi Nicoletta, Libri Valentina, Benassi Barbara, Mattei Elisabetta, Chersi Alberto, Soddu Silvia, Floridi Aristide, Passananti Claudio, Fanciulli Maurizio |year=[[2002]]|month=Nov. |title=Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb |journal=Cancer Cell |volume=2 |issue=5 |pages=387–99 |publisher= |location = United States| issn = 1535-6108| pmid = 12450794 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S1535-6108(02)00182-4 }}</ref>


==References==
== Interactions ==

Protein AATF has been shown to [[Protein-protein interaction|interact]] with:
* [[PAWR]],<ref name = pmid14627703>{{cite journal | vauthors = Guo Q, Xie J | title = AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 6 | pages = 4596–603 | date = Feb 2004 | pmid = 14627703 | doi = 10.1074/jbc.M309811200 | doi-access = free }}</ref>
* [[POLR2J]],<ref name = pmid10783144/>
* [[Retinoblastoma protein]],<ref name = pmid10783144/><ref name = pmid12450794>{{cite journal | vauthors = Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, Libri V, Benassi B, Mattei E, Chersi A, Soddu S, Floridi A, Passananti C, Fanciulli M | title = Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb | journal = Cancer Cell | volume = 2 | issue = 5 | pages = 387–99 | date = Nov 2002 | pmid = 12450794 | doi = 10.1016/s1535-6108(02)00182-4| author14 = Fanciulli Maurizio | author13 = Passananti Claudio | doi-access = free }}</ref> and
* [[Transcription factor Sp1]].<ref name = pmid12847090>{{cite journal | vauthors = Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M | title = Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter | journal = The Journal of Biological Chemistry | volume = 278 | issue = 38 | pages = 36496–504 | date = Sep 2003 | pmid = 12847090 | doi = 10.1074/jbc.M306694200 | doi-access = free }}</ref>

== References ==
{{reflist}}
{{reflist}}

==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Page G, Lödige I, Kögel D, Scheidtmann KH | title = AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis | journal = FEBS Letters | volume = 462 | issue = 1–2 | pages = 187–91 | date = Nov 1999 | pmid = 10580117 | doi = 10.1016/S0014-5793(99)01529-X | s2cid = 6061613 | doi-access = free }}
{{PBB_Further_reading
* {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Current Biology | volume = 12 | issue = 1 | pages = 1–11 | date = Jan 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 | s2cid = 14132033 | doi-access = free | bibcode = 2002CBio...12....1A }}
| citations =
*{{cite journal | author=Page G, Lödige I, Kögel D, Scheidtmann KH |title=AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis. |journal=FEBS Lett. |volume=462 |issue= 1-2 |pages= 187–91 |year= 2000 |pmid= 10580117 |doi=10.1016/S0014-5793(99)01529-X }}
* {{cite journal | vauthors = Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ | title = Functional proteomic analysis of human nucleolus | journal = Molecular Biology of the Cell | volume = 13 | issue = 11 | pages = 4100–9 | date = Nov 2002 | pmid = 12429849 | pmc = 133617 | doi = 10.1091/mbc.E02-05-0271 }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 }}
* {{cite journal | vauthors = Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, Libri V, Benassi B, Mattei E, Chersi A, Soddu S, Floridi A, Passananti C, Fanciulli M | title = Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb | journal = Cancer Cell | volume = 2 | issue = 5 | pages = 387–99 | date = Nov 2002 | pmid = 12450794 | doi = 10.1016/S1535-6108(02)00182-4 | doi-access = free }}
*{{cite journal | author=Scherl A, Couté Y, Déon C, ''et al.'' |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100–9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 | pmc=133617 }}
* {{cite journal | vauthors = Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M | title = Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter | journal = The Journal of Biological Chemistry | volume = 278 | issue = 38 | pages = 36496–504 | date = Sep 2003 | pmid = 12847090 | doi = 10.1074/jbc.M306694200 | doi-access = free }}
*{{cite journal | author=Bruno T, De Angelis R, De Nicola F, ''et al.'' |title=Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb. |journal=Cancer Cell |volume=2 |issue= 5 |pages= 387–99 |year= 2003 |pmid= 12450794 |doi=10.1016/S1535-6108(02)00182-4 }}
* {{cite journal | vauthors = Guo Q, Xie J | title = AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 6 | pages = 4596–603 | date = Feb 2004 | pmid = 14627703 | doi = 10.1074/jbc.M309811200 | doi-access = free }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
* {{cite journal | vauthors = Barbato C, Corbi N, Canu N, Fanciulli M, Serafino A, Ciotti M, Libri V, Bruno T, Amadoro G, De Angelis R, Calissano P, Passananti C | title = Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis | journal = Molecular and Cellular Neurosciences | volume = 24 | issue = 4 | pages = 1038–50 | date = Dec 2003 | pmid = 14697667 | doi = 10.1016/j.mcn.2003.08.002 | hdl = 2108/56917 | s2cid = 35111183 | hdl-access = free }}
*{{cite journal | author=Di Padova M, Bruno T, De Nicola F, ''et al.'' |title=Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36496–504 |year= 2003 |pmid= 12847090 |doi= 10.1074/jbc.M306694200 }}
* {{cite journal | vauthors = Burgdorf S, Leister P, Scheidtmann KH | title = TSG101 interacts with apoptosis-antagonizing transcription factor and enhances androgen receptor-mediated transcription by promoting its monoubiquitination | journal = The Journal of Biological Chemistry | volume = 279 | issue = 17 | pages = 17524–34 | date = Apr 2004 | pmid = 14761944 | doi = 10.1074/jbc.M313703200 | doi-access = free }}
*{{cite journal | author=Guo Q, Xie J |title=AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4. |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4596–603 |year= 2004 |pmid= 14627703 |doi= 10.1074/jbc.M309811200 }}
* {{cite journal | vauthors = Xie J, Guo Q | title = AATF protects neural cells against oxidative damage induced by amyloid beta-peptide | journal = Neurobiology of Disease | volume = 16 | issue = 1 | pages = 150–7 | date = Jun 2004 | pmid = 15207272 | doi = 10.1016/j.nbd.2004.02.003 | s2cid = 53204920 }}
*{{cite journal | author=Barbato C, Corbi N, Canu N, ''et al.'' |title=Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis. |journal=Mol. Cell. Neurosci. |volume=24 |issue= 4 |pages= 1038–50 |year= 2004 |pmid= 14697667 |doi=10.1016/j.mcn.2003.08.002 }}
* {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = Jul 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | date = Jan 2005 | pmid = 15635413 | doi = 10.1038/nature03207 | bibcode = 2005Natur.433...77A | s2cid = 4344740 }}
* {{cite journal|author-link30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}
*{{cite journal | author=Burgdorf S, Leister P, Scheidtmann KH |title=TSG101 interacts with apoptosis-antagonizing transcription factor and enhances androgen receptor-mediated transcription by promoting its monoubiquitination. |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 17524–34 |year= 2004 |pmid= 14761944 |doi= 10.1074/jbc.M313703200 }}
*{{cite journal | author=Xie J, Guo Q |title=AATF protects neural cells against oxidative damage induced by amyloid beta-peptide. |journal=Neurobiol. Dis. |volume=16 |issue= 1 |pages= 150–7 |year= 2004 |pmid= 15207272 |doi= 10.1016/j.nbd.2004.02.003 }}
* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6 | date = Apr 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 | bibcode = 2006PNAS..103.5391N | doi-access = free }}
*{{cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }}
* {{cite journal | vauthors = Kaul D, Mehrotra A | title = Functional characterization of AATF transcriptome in human leukemic cells | journal = Molecular and Cellular Biochemistry | volume = 297 | issue = 1–2 | pages = 215–20 | date = Mar 2007 | pmid = 17006618 | doi = 10.1007/s11010-006-9317-1 | s2cid = 8612000 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 }}
*{{cite journal | author=Kaul D, Mehrotra A |title=Functional characterization of AATF transcriptome in human leukemic cells. |journal=Mol. Cell. Biochem. |volume=297 |issue= 1-2 |pages= 215–20 |year= 2007 |pmid= 17006618 |doi= 10.1007/s11010-006-9317-1 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
*{{MeshName|AATF+protein,+human}}
*{{MeshName|AATF+protein,+human}}
* {{UCSC genome browser|AATF}}
* {{UCSC gene details|AATF}}


{{NLM content}}
{{NLM content}}
{{Transcription factors|g1}}
{{Transcription factors|g1}}


<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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| update_protein_box = yes
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[[Category:Transcription factors]]
[[Category:Transcription factors]]



{{gene-17-stub}}
{{gene-17-stub}}

[[es:AATF]]

Latest revision as of 22:33, 27 March 2024

AATF
Identifiers
AliasesAATF, BFR2, CHE-1, CHE1, DED, Apoptosis-antagonizing transcription factor, apoptosis antagonizing transcription factor
External IDsOMIM: 608463; MGI: 1929608; HomoloGene: 40811; GeneCards: AATF; OMA:AATF - orthologs
Orthologs
SpeciesHumanMouse
Entrez

26574

56321

Ensembl

ENSG00000275700
ENSG00000276072

ENSMUSG00000018697

UniProt

Q9NY61

Q9JKX4

RefSeq (mRNA)

NM_012138

NM_019816

RefSeq (protein)

NP_036270

NP_062790

Location (UCSC)Chr 17: 36.95 – 37.06 MbChr 11: 84.42 – 84.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein AATF, also known as apoptosis-antagonizing transcription factor is a protein that in humans is encoded by the AATF gene.[5][6][7]

Function

[edit]

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.[7]

Interactions

[edit]

Protein AATF has been shown to interact with:

References

[edit]
  1. ^ a b c ENSG00000276072 GRCh38: Ensembl release 89: ENSG00000275700, ENSG00000276072 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018697 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lindfors K, Halttunen T, Huotari P, Nupponen N, Vihinen M, Visakorpi T, Mäki M, Kainulainen H (Sep 2000). "Identification of novel transcription factor-like gene from human intestinal cells". Biochemical and Biophysical Research Communications. 276 (2): 660–6. doi:10.1006/bbrc.2000.3480. PMID 11027528.
  6. ^ a b c Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C (May 2000). "Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb". FASEB Journal. 14 (7): 904–12. doi:10.1096/fasebj.14.7.904. PMID 10783144. S2CID 43175069.
  7. ^ a b "Entrez Gene: AATF apoptosis antagonizing transcription factor".
  8. ^ Guo Q, Xie J (Feb 2004). "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4". The Journal of Biological Chemistry. 279 (6): 4596–603. doi:10.1074/jbc.M309811200. PMID 14627703.
  9. ^ Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, Libri V, Benassi B, Mattei E, Chersi A, Soddu S, Floridi A, Passananti C, Fanciulli M (Nov 2002). "Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb". Cancer Cell. 2 (5): 387–99. doi:10.1016/s1535-6108(02)00182-4. PMID 12450794.
  10. ^ Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M (Sep 2003). "Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter". The Journal of Biological Chemistry. 278 (38): 36496–504. doi:10.1074/jbc.M306694200. PMID 12847090.

Further reading

[edit]
[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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