Protein AATF: Difference between revisions

AATF
Identifiers
Aliases	AATF, BFR2, CHE-1, CHE1, DED, Apoptosis-antagonizing transcription factor, apoptosis antagonizing transcription factor
External IDs	OMIM: 608463; MGI: 1929608; HomoloGene: 40811; GeneCards: AATF; OMA:AATF - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	37,056,871 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	84,513,522 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; corpus callosum; ; Achilles tendon; ; tibial arteries; ; blood; ; skin of leg; ; bone marrow; ; body of pancreas; ; sural nerve;
	Top expressed in
	morula; ; epiblast; ; embryo; ; tail of embryo; ; genital tubercle; ; primary oocyte; ; yolk sac; ; endothelial cell of lymphatic vessel; ; spermatocyte; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein domain specific binding; DNA-binding transcription factor activity; leucine zipper domain binding; protein binding; tau protein binding; RNA binding; protein kinase binding;
Cellular component	cytoplasm; Golgi apparatus; nucleus; nucleolus;
Biological process	embryonic cleavage; ribosome biogenesis; negative regulation of apoptotic process; cellular response to DNA damage stimulus; positive regulation of transcription, DNA-templated; cell adhesion; negative regulation of amyloid precursor protein biosynthetic process; regulation of mitotic cell cycle; negative regulation of superoxide anion generation; negative regulation of reactive oxygen species metabolic process; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	26574
	56321
	ENSG00000275700; ENSG00000276072
	ENSMUSG00000018697
	Q9NY61
	Q9JKX4
	NM_012138
	NM_019816
	NP_036270
	NP_062790
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 22:33, 27 March 2024

Protein AATF, also known as apoptosis-antagonizing transcription factor is a protein that in humans is encoded by the AATF gene.^[5]^[6]^[7]

Function

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.^[7]

Interactions

Protein AATF has been shown to interact with:

References

^ ^a ^b ^c ENSG00000276072 GRCh38: Ensembl release 89: ENSG00000275700, ENSG00000276072 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018697 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lindfors K, Halttunen T, Huotari P, Nupponen N, Vihinen M, Visakorpi T, Mäki M, Kainulainen H (Sep 2000). "Identification of novel transcription factor-like gene from human intestinal cells". Biochemical and Biophysical Research Communications. 276 (2): 660–6. doi:10.1006/bbrc.2000.3480. PMID 11027528.
^ ^a ^b ^c Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C (May 2000). "Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb". FASEB Journal. 14 (7): 904–12. doi:10.1096/fasebj.14.7.904. PMID 10783144. S2CID 43175069.
^ ^a ^b "Entrez Gene: AATF apoptosis antagonizing transcription factor".
^ Guo Q, Xie J (Feb 2004). "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4". The Journal of Biological Chemistry. 279 (6): 4596–603. doi:10.1074/jbc.M309811200. PMID 14627703.
^ Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, Libri V, Benassi B, Mattei E, Chersi A, Soddu S, Floridi A, Passananti C, Fanciulli M (Nov 2002). "Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb". Cancer Cell. 2 (5): 387–99. doi:10.1016/s1535-6108(02)00182-4. PMID 12450794.
^ Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M (Sep 2003). "Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter". The Journal of Biological Chemistry. 278 (38): 36496–504. doi:10.1074/jbc.M306694200. PMID 12847090.

External links

AATF+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
AATF human gene location in the UCSC Genome Browser.
AATF human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000276072 GRCh38: Ensembl release 89: ENSG00000275700, ENSG00000276072 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018697 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11027528-5] Lindfors K, Halttunen T, Huotari P, Nupponen N, Vihinen M, Visakorpi T, Mäki M, Kainulainen H (Sep 2000). "Identification of novel transcription factor-like gene from human intestinal cells". Biochemical and Biophysical Research Communications. 276 (2): 660–6. doi:10.1006/bbrc.2000.3480. PMID 11027528.

[pmid10783144-6] Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C (May 2000). "Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb". FASEB Journal. 14 (7): 904–12. doi:10.1096/fasebj.14.7.904. PMID 10783144. S2CID 43175069.

[entrez-7] "Entrez Gene: AATF apoptosis antagonizing transcription factor".

[pmid14627703-8] Guo Q, Xie J (Feb 2004). "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4". The Journal of Biological Chemistry. 279 (6): 4596–603. doi:10.1074/jbc.M309811200. PMID 14627703.

[pmid12450794-9] Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, Libri V, Benassi B, Mattei E, Chersi A, Soddu S, Floridi A, Passananti C, Fanciulli M (Nov 2002). "Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb". Cancer Cell. 2 (5): 387–99. doi:10.1016/s1535-6108(02)00182-4. PMID 12450794.

[pmid12847090-10] Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M (Sep 2003). "Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter". The Journal of Biological Chemistry. 278 (38): 36496–504. doi:10.1074/jbc.M306694200. PMID 12847090.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
 {{Infobox_gene}}
-'''Protein AATF''' is a [[protein]] that in humans is encoded by the ''AATF'' [[gene]].<ref name="pmid11027528">{{cite journal | vauthors = Lindfors K, Halttunen T, Huotari P, Nupponen N, Vihinen M, Visakorpi T, Mäki M, Kainulainen H | title = Identification of novel transcription factor-like gene from human intestinal cells | journal = Biochemical and Biophysical Research Communications | volume = 276 | issue = 2 | pages = 660–6 | date = Sep 2000 | pmid = 11027528 | doi = 10.1006/bbrc.2000.3480 }}</ref><ref name="pmid10783144">{{cite journal | vauthors = Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C | title = Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb | journal = FASEB Journal | volume = 14 | issue = 7 | pages = 904–12 | date = May 2000 | pmid = 10783144 | doi =  10.1096/fasebj.14.7.904| s2cid = 43175069 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AATF apoptosis antagonizing transcription factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26574}}</ref>
+'''Protein AATF''', also known as '''apoptosis-antagonizing transcription factor''' is a [[protein]] that in humans is encoded by the ''AATF'' [[gene]].<ref name="pmid11027528">{{cite journal | vauthors = Lindfors K, Halttunen T, Huotari P, Nupponen N, Vihinen M, Visakorpi T, Mäki M, Kainulainen H | title = Identification of novel transcription factor-like gene from human intestinal cells | journal = Biochemical and Biophysical Research Communications | volume = 276 | issue = 2 | pages = 660–6 | date = Sep 2000 | pmid = 11027528 | doi = 10.1006/bbrc.2000.3480 }}</ref><ref name="pmid10783144">{{cite journal | vauthors = Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C | title = Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb | journal = FASEB Journal | volume = 14 | issue = 7 | pages = 904–12 | date = May 2000 | pmid = 10783144 | doi =  10.1096/fasebj.14.7.904| doi-access = free | s2cid = 43175069 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AATF apoptosis antagonizing transcription factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26574}}</ref>
 == Function ==
@@ Line 8: / Line 9: @@
 == Interactions ==
-Apoptosis-antagonizing transcription factor has been shown to [[Protein-protein interaction|interact]] with:
+Protein AATF has been shown to [[Protein-protein interaction|interact]] with:
 * [[PAWR]],<ref name = pmid14627703>{{cite journal | vauthors = Guo Q, Xie J | title = AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 6 | pages = 4596–603 | date = Feb 2004 | pmid = 14627703 | doi = 10.1074/jbc.M309811200 | doi-access = free }}</ref>
 * [[POLR2J]],<ref name = pmid10783144/>
-* [[Retinoblastoma protein]],<ref name = pmid10783144/><ref name = pmid12450794>{{cite journal | vauthors = Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, Libri V, Benassi B, Mattei E, Chersi A, Soddu S, Floridi A, Passananti C, Fanciulli M | title = Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb | journal = Cancer Cell | volume = 2 | issue = 5 | pages = 387–99 | date = Nov 2002 | pmid = 12450794 | doi =  10.1016/s1535-6108(02)00182-4| author14 = Fanciulli Maurizio | author13 = Passananti Claudio }}</ref> and
+* [[Retinoblastoma protein]],<ref name = pmid10783144/><ref name = pmid12450794>{{cite journal | vauthors = Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, Libri V, Benassi B, Mattei E, Chersi A, Soddu S, Floridi A, Passananti C, Fanciulli M | title = Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb | journal = Cancer Cell | volume = 2 | issue = 5 | pages = 387–99 | date = Nov 2002 | pmid = 12450794 | doi =  10.1016/s1535-6108(02)00182-4| author14 = Fanciulli Maurizio | author13 = Passananti Claudio | doi-access = free }}</ref> and
-* [[Sp1 transcription factor]].<ref name = pmid12847090>{{cite journal | vauthors = Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M | title = Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter | journal = The Journal of Biological Chemistry | volume = 278 | issue = 38 | pages = 36496–504 | date = Sep 2003 | pmid = 12847090 | doi = 10.1074/jbc.M306694200 | doi-access = free }}</ref>
+* [[Transcription factor Sp1]].<ref name = pmid12847090>{{cite journal | vauthors = Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M | title = Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter | journal = The Journal of Biological Chemistry | volume = 278 | issue = 38 | pages = 36496–504 | date = Sep 2003 | pmid = 12847090 | doi = 10.1074/jbc.M306694200 | doi-access = free }}</ref>
 == References ==
@@ Line 20: / Line 21: @@
 {{refbegin | 2}}
 * {{cite journal | vauthors = Page G, Lödige I, Kögel D, Scheidtmann KH | title = AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis | journal = FEBS Letters | volume = 462 | issue = 1–2 | pages = 187–91 | date = Nov 1999 | pmid = 10580117 | doi = 10.1016/S0014-5793(99)01529-X | s2cid = 6061613 | doi-access = free }}
-* {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Current Biology | volume = 12 | issue = 1 | pages = 1–11 | date = Jan 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 | s2cid = 14132033 }}
+* {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Current Biology | volume = 12 | issue = 1 | pages = 1–11 | date = Jan 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 | s2cid = 14132033 | doi-access = free | bibcode = 2002CBio...12....1A }}
 * {{cite journal | vauthors = Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ | title = Functional proteomic analysis of human nucleolus | journal = Molecular Biology of the Cell | volume = 13 | issue = 11 | pages = 4100–9 | date = Nov 2002 | pmid = 12429849 | pmc = 133617 | doi = 10.1091/mbc.E02-05-0271 }}
-* {{cite journal | vauthors = Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, Libri V, Benassi B, Mattei E, Chersi A, Soddu S, Floridi A, Passananti C, Fanciulli M | title = Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb | journal = Cancer Cell | volume = 2 | issue = 5 | pages = 387–99 | date = Nov 2002 | pmid = 12450794 | doi = 10.1016/S1535-6108(02)00182-4 }}
+* {{cite journal | vauthors = Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, Libri V, Benassi B, Mattei E, Chersi A, Soddu S, Floridi A, Passananti C, Fanciulli M | title = Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb | journal = Cancer Cell | volume = 2 | issue = 5 | pages = 387–99 | date = Nov 2002 | pmid = 12450794 | doi = 10.1016/S1535-6108(02)00182-4 | doi-access = free }}
 * {{cite journal | vauthors = Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M | title = Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter | journal = The Journal of Biological Chemistry | volume = 278 | issue = 38 | pages = 36496–504 | date = Sep 2003 | pmid = 12847090 | doi = 10.1074/jbc.M306694200 | doi-access = free }}
 * {{cite journal | vauthors = Guo Q, Xie J | title = AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 6 | pages = 4596–603 | date = Feb 2004 | pmid = 14627703 | doi = 10.1074/jbc.M309811200 | doi-access = free }}
@@ Line 31: / Line 32: @@
 * {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | date = Jan 2005 | pmid = 15635413 | doi = 10.1038/nature03207 | bibcode = 2005Natur.433...77A | s2cid = 4344740 }}
 * {{cite journal|author-link30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}
-* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6 | date = Apr 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 | bibcode = 2006PNAS..103.5391N }}
+* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6 | date = Apr 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 | bibcode = 2006PNAS..103.5391N | doi-access = free }}
 * {{cite journal | vauthors = Kaul D, Mehrotra A | title = Functional characterization of AATF transcriptome in human leukemic cells | journal = Molecular and Cellular Biochemistry | volume = 297 | issue = 1–2 | pages = 215–20 | date = Mar 2007 | pmid = 17006618 | doi = 10.1007/s11010-006-9317-1 | s2cid = 8612000 }}
-* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 }}
+* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}
 {{refend}}

Latest revision as of 22:33, 27 March 2024

Function

Interactions

References

Further reading

External links