Roussel Uclaf: Difference between revisions
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'''Roussel Uclaf S.A.''' was a [[France|French]] [[pharmaceutical industry|pharmaceutical company]] and one of several predecessor companies of today's [[Sanofi]]. |
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⚫ | It was the second largest French pharmaceutical company<ref>{{cite news |author=. |date=October 14, 1997 |title=Roussel Uclaf disappears, giving way to Hoechst Marion Russell |work=Chemical Business NewsBase |location=Cambridge |publisher=Royal Society of Chemistry}} 2nd largest pharmaceutical company (after [[Rhône-Poulenc]] and ahead of Sanofi)</ref> before it was acquired by [[Hoechst AG]] of [[Frankfurt am Main|Frankfurt]], [[Germany]] in 1997, with pharmaceutical operations combined into the [[Marion Merrell Dow|Hoechst Marion Roussel]] (HMR) division in the United States. Roussel Uclaf's [[agrochemical]] operations had been transferred to [[Hoechst Schering AgrEvo GmbH]] in 1994. |
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⚫ | HMR subsequently merged in 1999 with [[Rhône-Poulenc]] to form [[Aventis]], which then merged in 2004 with [[Sanofi-Synthélabo]] to form [[Sanofi-Aventis]]. Hoechst Schering AgrEvo merged in 1999 with Rhône-Poulenc's agrochemical division to form Aventis CropScience, which was acquired by [[Bayer|Bayer AG]] in 2002 and combined with Bayer's agrochemical division to form Bayer CropScience. |
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⚫ | HMR subsequently merged in 1999 with [[Rhône-Poulenc]] to form [[Aventis]], which then merged in 2004 with [[Sanofi-Synthélabo]] to form [[Sanofi-Aventis]], which was since renamed Sanofi. Hoechst Schering AgrEvo merged in 1999 with Rhône-Poulenc's agrochemical division to form Aventis CropScience, which was acquired by [[Bayer|Bayer AG]] in 2002 and combined with Bayer's agrochemical division to form Bayer CropScience. |
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== RU-486 == |
== RU-486 == |
Revision as of 03:21, 11 September 2015
Company type | Public (Société anonyme) |
---|---|
Industry | Pharmaceutical |
Founded | Paris, France (1911 ) Institut de Sérothérapie Hémopoïétique ISH (1920) Usines Chimiques des Laboratoires Français UCLAF (1928) Société Française de la Pénicilline SOFRAPEN (1947) (Roussel-Uclaf, S.A. incorporated 1961) |
Founder | Gaston Roussel |
Defunct | September 30, 1997[1] |
Fate | Acquired |
Successor | Hoechst AG (Hoechst Marion Roussel) |
Headquarters | Paris, France (1911–1995) Romainville, France (1995–1997)[2] |
Area served | Worldwide |
Key people | Gaston Roussel (CEO, 1911–1947) Jean-Claude Roussel (CEO, 1961–1972) Jacques Machizaud (CEO, 1974–1981) Édouard Sakiz (CEO, 1981–1993) Ernst-Günter Afting (CEO, 1994–1995) Jean-Pierre Godard (CEO, 1995–1997) |
Products | Hemostyl (erythropoietin, horse serum) Rubiazol (carboxysulfamidochrysoidine) Rythmodan (disopyramide) Decis (deltamethrin) Surgam (tiaprofenic acid) Claforan (cefotaxime sodium) Mifegyne (mifepristone, RU-486) Anandron (nilutamide) |
Revenue | |
Number of employees | 15,673 worldwide (1992)[4] 8,409 in France (1992)[4] 6,533 in France (1996)[5] |
Roussel Uclaf S.A. was a French pharmaceutical company and one of several predecessor companies of today's Sanofi.
It was the second largest French pharmaceutical company[6] before it was acquired by Hoechst AG of Frankfurt, Germany in 1997, with pharmaceutical operations combined into the Hoechst Marion Roussel (HMR) division in the United States. Roussel Uclaf's agrochemical operations had been transferred to Hoechst Schering AgrEvo GmbH in 1994.
HMR subsequently merged in 1999 with Rhône-Poulenc to form Aventis, which then merged in 2004 with Sanofi-Synthélabo to form Sanofi-Aventis, which was since renamed Sanofi. Hoechst Schering AgrEvo merged in 1999 with Rhône-Poulenc's agrochemical division to form Aventis CropScience, which was acquired by Bayer AG in 2002 and combined with Bayer's agrochemical division to form Bayer CropScience.
RU-486
In April 1980, as part of a formal research project at Roussel-Uclaf for the development of glucocorticoid receptor antagonists, chemist Georges Teutsch synthesized mifepristone (RU-38486, the 38,486th compound synthesized by Roussel-Uclaf from 1949 to 1980; shortened to RU-486); which was discovered to also be a progesterone receptor antagonist.[7][8] In October 1981, endocrinologist Étienne-Émile Baulieu, a consultant to Roussel-Uclaf, arranged tests of its use for medical abortion in eleven women in Switzerland by gynecologist Walter Herrmann at the University of Geneva's Cantonal Hospital, with successful results announced on April 19, 1982.[7][9] On October 9, 1987, following worldwide clinical trials in 20,000 women of mifepristone with a prostaglandin analogue (initially sulprostone or gemeprost, later misoprostol) for medical abortion, Roussel-Uclaf sought approval in France for their use for medical abortion, with approval announced on September 23, 1988.[7][10]
On October 21, 1988, in response to antiabortion protests and concerns of majority (54.5%) owner Hoechst AG of Germany, Roussel-Uclaf’s executives and board of directors voted 16 to 4 to stop distribution of mifepristone, which they announced on October 26, 1988.[7][11] Two days later, the French government ordered Roussel-Uclaf to distribute mifepristone in the interests of public health.[7][12] French Health Minister Claude Évin explained that: "I could not permit the abortion debate to deprive women of a product that represents medical progress. From the moment Government approval for the drug was granted, RU-486 became the moral property of women, not just the property of a drug company."[7] Following use by 34,000 women in France from April 1988 to February 1990 of mifepristone distributed free of charge, Roussel-Uclaf began selling Mifegyne (mifepristone) to hospitals in France in February 1990 at a price (negotiated with the French government) of $48 per 600 mg dose.[7]
Mifegyne was subsequently approved in Great Britain on July 1, 1991,[13] and in Sweden in September 1992,[14] but until his retirement in late April 1994, Hoechst AG chairman Wolfgang Hilger, a devout Roman Catholic, blocked any further expansion in availability.[7][15] On May 16, 1994, Roussel-Uclaf announced that it was donating without remuneration all rights for medical uses of mifepristone in the U.S. to the Population Council,[16] which subsequently licensed mifepristone to Danco Laboratories, a new single-product company immune to antiabortion boycotts, which won FDA approval as Mifeprex on September 28, 2000.[17]
On April 8, 1997, after buying the remaining 43.5% of Roussel-Uclaf stock in early 1997,[18] Hoechst AG ($30 billion annual revenue) announced the end of its manufacture and sale of Mifegyne ($3.44 million annual revenue) and the transfer of all rights for medical uses of mifepristone outside of the U.S. to Exelgyn S.A., a new single-product company immune to antiabortion boycotts, whose CEO was former Roussel-Uclaf CEO Édouard Sakiz.[19] In 1999, Exelgyn won approval of Mifegyne in 11 additional countries, and in 28 more countries over the following decade.[20]
References
- ^ Flallo, Laurent (October 2, 1997). "Hoechst Marion Roussel France touché par une des taxes Aubry". Les Échos. p. 8. Hoechst Marion Roussel France - ex-Roussel Uclaf, which juridically disappeared yesterday...
- ^ Aizicovici, Francine (March 7, 1994). "Le désarroi des salariés". Le Monde. headquarters moved to Romainville in April 1995 after 40 years at 35 Boulevard des Invalides, Paris.
- ^ a b . (February 18, 1997). "Roussel UCLAF : profits en hausse de 11%". l'Humanité.
{{cite news}}
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has numeric name (help)
. (February 18, 1997). "Hoechst AG: Roussel Uclaf unit posts net profit increase of 90%". The Wall Street Journal. p. A6.{{cite news}}
:|author=
has numeric name (help) 1996: $3.01 billion sales, $339.5 million net profit - ^ a b . (May 5, 1993). "Country focus: French chemicals: an industry review". Chemical Week. p. S14.
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has numeric name (help)Roussel Uclaf
Sales 1992: F14.8 billion (3.5%). Profit before tax 1992: F1.439 billion (43%). Investment in assets 1992: F930 million (11.8%). Acquisitions in 1992: F452 million. Employees: 15,673; 8,409 of whom are in France. Principal products: Pharmaceuticals (57% of sales), agroveterinary products (23%), bulk pharmaceuticals (13%) and OTC and cosmetics (4%). Roussel Uclaf is owned 65% by Hoechst and 35% by Rhone-Poulenc, which might soon sell its stake to Hoechst. Headquarters: Paris. - ^ Lemaître, Frédéric (December 3, 1996). "Roussel-Uclaf adopte les 35 heures de travail hebdomadaires sans perte de salaire". Le Monde. 6,533 employees in France
- ^ . (October 14, 1997). "Roussel Uclaf disappears, giving way to Hoechst Marion Russell". Chemical Business NewsBase. Cambridge: Royal Society of Chemistry.
{{cite news}}
:|author=
has numeric name (help) 2nd largest pharmaceutical company (after Rhône-Poulenc and ahead of Sanofi) - ^ a b c d e f g h Baulieu, Étienne-Émile; Rosenblum, Mort (1991). The "abortion pill" : RU-486, a woman's choice. New York: Simon & Schuster. ISBN 0-671-73816-X.
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: CS1 maint: multiple names: authors list (link)
Lader, Lawrence (1991). RU 486 : the pill that could end the abortion wars and why American women don't have it. Reading: Addison-Wesley. ISBN 0-201-57069-6.
Villaran, Gilda (1998). "RU 486". In Schlegelmilch, Bodo B. (ed.). Marketing ethics : an international perspective. London: Thomson Learing. pp. 155–190. ISBN 1-86152-191-X.
Ulmann, André (2000). "The development of mifepristone: a pharmaceutical drama in three acts". J Am Med Womens Assoc. 55 (3 Suppl): 117–20. PMID 10846319. - ^ Teutsch, Georges (November 24, 1989). "RU 486 development". Science. 246 (4933): 985. doi:10.1126/science.2587990. PMID 2587990.
"Dispute surfaces over paternity of RU 486". Science. 246 (4933): 994. November 24, 1989. doi:10.1126/science.2587988. PMID 2587988.{{cite journal}}
: Unknown parameter|authors=
ignored (help)
"RU 486 development". Science. 246 (4943): 622. February 9, 1990. doi:10.1126/science.2300819. PMID 2300819.{{cite journal}}
: Unknown parameter|authors=
ignored (help)
Ullman, André; Teutsch, Georges; Philibert, Daniel (June 1990). "RU 486". Sci Am. 262 (6): 42–8. doi:10.1038/scientificamerican0690-42. PMID 2343294.{{cite journal}}
: CS1 maint: multiple names: authors list (link)
Teutsch, G.; Deraedt, R.; Philibert, D. (1993). "Mifepristone". In Lednicer, Daniel (ed.). Chronicles of drug discovery, Vol. 3. Washington, DC: American Chemical Society. pp. 1–43. ISBN 0-8412-2523-0.{{cite book}}
: CS1 maint: multiple names: authors list (link)
Philibert, Daniel; Teutsch, Georges (June 1994). "History and perspectives of antiprogestins from the chemist's point of view". Human Reprod. 9 (Suppl 1): 12–31. doi:10.1093/humrep/9.suppl_1.12. PMID 7962457.
. (2007). "Mifepristone". In Sittig, Marshall (ed.). Pharmaceutical manufacturing encyclopedia (3rd ed.). Norwich, NY: William Andrew Publishing. pp. 2307–2310. ISBN 1-60119-339-4.{{cite book}}
:|author=
has numeric name (help)
US patent 4,386,085, Teutsch, Jean G.; Costerousse, Germain; Philibert, Daniel; Deraedt, Roger, "Novel steroids", issued 1983-05-31 assigned to Roussel Uclaf - ^ Eder, Richard (April 20, 1982). "Birth control: 4-day pill is promising in early test". The New York Times. p. C1.
Herrmann, Walter; Wyss, Rolf; Riondel, Anne; Philibert, Daniel; Teutsch, Georges; Sakiz, Edouard; Baulieu, Étienne-Émile (May 17, 1982). "The effects of an antiprogesterone steroid in women: interruption of the menstrual cycle and of early pregnancy". C R Seances Acad Sci III. 294 (18): 933–8. PMID 6814714.{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ Kolata, Gina (September 24, 1988). "France and China allow sale of a drug for early abortion". The New York Times. p. A1.
- ^ Greenhouse, Steven (October 27, 1988). "Drug maker stops all distribution of abortion pill". The New York Times. p. A1.
- ^ Greenhouse, Steven (October 29, 1988). "France ordering company to sell its abortion drug". The New York Times. p. A1.
- ^ Smith, W. (September 1991). "Great Britain second country to allow use of RU-486". Plan Parent Eur. 20 (2): 20. PMID 12284548.
- ^ . (December 1992). "RU 486 licensed in Sweden". IPPF Med Bull. 26 (6): 6. PMID 12346922.
{{cite journal}}
:|author=
has numeric name (help) - ^ Newman, Barry (February 22, 1993). "Drug dilemma: among those wary of abortion pill is maker's parent firm; Germany's Hoechst is facing pressure from Clinton to sell RU-486 in U.S.". The Wall Street Journal. p. A1.
Associated Press (April 16, 1993). "F.D.A. says company delays abortion pill". The New York Times. p. A14.
Jouzaitis, Carol (October 17, 1994). "Abortion pill battle surprises French firm". Chicago Tribune. p. 1 (Business). - ^ Seelye, Katharine Q. (May 17, 1994). "Accord opens way for abortion pill in U.S. in 2 years". The New York Times. p. A1.
- ^ Kolata, Gina (September 29, 2000). "U.S. approves abortion pill; drug offers more privacy and could reshape debate". The New York Times. p. A1.
- ^ Moore, Stephen D.; Kamm, Thomas; Fleming, Charles (December 11, 1996). "Hoechst to seek rest of Roussel-Uclaf; expected $3.04 billion offer would add to the wave of drug-sector linkups". The Wall Street Journal. p. A3.
{{cite news}}
: CS1 maint: multiple names: authors list (link)
Marshall, Matt (December 11, 1996). "Hoechst offers to pay $3.6 billion for rest of Roussel". The Wall Street Journal. p. A8.
Bloomberg Business News (December 11, 1996). "Hoechst to buy rest of Roussel". The New York Times. p. D4.{{cite news}}
:|author=
has generic name (help) - ^ Bloomberg News (April 9, 1997). "Pill for abortion ends production". The New York Times. p. D2.
Jouzaitis, Carol (April 9, 1997). "Abortion pill maker bows to boycott heat; German firm gives up RU-486 patent; little impact likely in U.S." Chicago Tribune. p. 4.
Lavin, Douglas (April 9, 1997). "Hoechst will stop making abortion pill". The Wall Street Journal. p. A3.
. (April 18, 1997). "Roussel-Uclaf to transfer RU 486 rights". Reprod Freedom News. 6 (7): 8. PMID 12292550.{{cite journal}}
:|author=
has numeric name (help)
Dorozynski, Alexander (April 19, 1997). "Boycott threat forces French company to abandon RU486". BMJ. 314 (7088): 1150. doi:10.1136/bmj.314.7088.1145m. PMC 2126515. PMID 9146386. - ^ . (November 4, 2009). "List of mifepristone approval" (PDF). New York: Gynuity Health Projects.
{{cite web}}
:|author=
has numeric name (help)
. (November 4, 2009). "Map of mifepristone approval" (PDF). New York: Gynuity Health Projects.{{cite web}}
:|author=
has numeric name (help)
Sources
- . (April 10, 1965). "Roussel takes off". Chemical Week. pp. 60, 62.
{{cite news}}
:|author=
has numeric name (help) - Cornwell, Rupert (1974). "France: the mask of modernity". In Rowley, Anthony (ed.) (ed.). The barons of European industry. London: Croom Helm. pp. 5–22. ISBN 0-85664-105-7.
{{cite book}}
:|editor=
has generic name (help) - . (1988). "Roussel Uclaf". In Derdak, Thomas (ed.) (ed.). International directory of company histories, Volume 1. Chicago: St. James Press. pp. 669–670. ISBN 0-912289-10-4.
{{cite book}}
:|author=
has numeric name (help);|editor=
has generic name (help) - Taggart, James (1993). "The European pharmaceutical industry". The world pharmaceutical industry. London: Routledge. pp. 316–370. ISBN 0-415-02500-1.
- Dougal, April S. (1994). "Roussel Uclaf". In Kepos, Paula (ed.) (ed.). International directory of company histories, Volume 8. Detroit: St. James Press. pp. 451–453. ISBN 1-55862-323-X.
{{cite book}}
:|editor=
has generic name (help); External link in
(help); Unknown parameter|chapterurl=
|chapterurl=
ignored (|chapter-url=
suggested) (help) - . (1999). "Hoechst Marion Roussel". The pharmaceutical industry: a history & calendar. West Lafayette: Bioanalytical Systems, Inc.
{{cite web}}
:|author=
has numeric name (help) - Furio, Antoine (2006). "Gaston Roussel to Sanofi-Aventis: nearly a century of Romainville pharmaceutical history and heritage" (PDF). Heritage in Seine-Saint-Denis, No. 15. Bobigny: General Council of Seine-Saint-Denis.
- . (2005). "History of Roussel laboratories". Paris: Society for the History of Pharmacy.
{{cite web}}
:|author=
has numeric name (help) - . (2008). "Some dates". Romainville: Biocitech.
{{cite web}}
:|author=
has numeric name (help) - Kugener, André (2008). "Opotherapie". Museum of Medical History. Luxembourg: Kugener.com.
- Rossignol, Sylvain (2008). Notre usine est un roman. Paris: La Découverte. ISBN 2-7071-5462-8.
- . (2008). "Photo gallery - Our factory is a novel". Paris: notreusineestunroman.com.
{{cite web}}
:|author=
has numeric name (help)