Methylhexanamine (also known as methylhexamine, 1,3-dimethylamylamine, 1,3-DMAA, dimethylamylamine, and DMAA; trade names Forthane and Geranamine) is an indirect sympathomimetic drug invented and developed by Eli Lilly and Company and marketed as an inhaled nasal decongestant from 1948 until it was voluntarily withdrawn from the market in the 1980s.[7]
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Other names | Methylhexaneamine, methylhexamine, geranamine, geranium extract, geranium oil, 2-amino-4-methylhexane, dimethylamylamine, DMAA, 1,3-dimethylamylamine, 1,3-DMAA, 1,3-dimethylpentylamine, 4-methyl-2-hexanamine, 4-methyl-2-hexylamine |
Routes of administration | Nasal spray, oral |
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Elimination half-life | ~8.5 hours |
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ECHA InfoCard | 100.002.997 |
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Formula | C7H17N |
Molar mass | 115.220 g·mol−1 |
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Since 2006 methylhexanamine has been sold extensively under many names as a stimulant or energy-boosting dietary supplement under the claim that it is similar to certain compounds found in geraniums, but its safety has been questioned as a number of adverse events and at least five deaths have been associated with methylhexanamine-containing supplements.[8] It is banned by many sports authorities and governmental agencies. Despite multiple warning letters from the FDA,[9] as of 2019, the stimulant remains available in sports and weight loss supplements in the US.[10]
History
editIn April 1944, Eli Lilly and Company introduced methylhexanamine under the brand name Forthane as an inhaled nasal decongestant; Lilly voluntarily withdrew methylhexanamine from the market in 1983.[11]: 12 The compound is an aliphatic amine; the pharmaceutical industry had a strong interest in compounds in this class as nasal decongestants in the early 20th century, which led to methylhexanamine and four other similar compounds being brought to market for that use: tuaminoheptane, octin (isometheptene), oenethyl (2-methylaminoheptane), and propylhexedrine; octin and oenethyl were eventually approved for use in keeping blood pressure sufficiently high for patients under anesthesia.[citation needed]: 95–96
Marketing as dietary supplement
editPatrick Arnold reintroduced methylhexanamine in 2006 as a dietary supplement,[12][13] after the final ban of ephedrine in the United States in 2005. Arnold introduced it under the trademarked name Geranamine, a name held by his company, Proviant Technologies. A large number of supplements focusing on fat loss and workout energy (thermogenic or general-purpose stimulants) used the ingredient in concert with other substances such as caffeine, a combination similar to the combination of ephedrine and caffeine.
Methylhexanamine-containing supplements sometimes list "geranium oil" or "geranium extract" as a source of methylhexanamine. However, geranium oils do not contain methylhexanamine, and the methylhexanamine in these supplements is added in the form of synthetic material.[14] A variety of studies have explored the possibility that DMAA is found in some types of geraniums, but at present, high quality evidence of DMAA's presence in plants is lacking.[15][16]
Methylhexanamine is synthesized by reacting 4-methylhexan-2-one with hydroxylamine, which converts the 4-methylhexan-2-one to 4-methylhexan-2-one oxime, which is reduced via catalytic hydrogenation; the resulting methylhexanamine can be purified by distillation.[17]: 995–996
Pharmacology
editMethylhexanamine is an indirect sympathomimetic drug that constricts blood vessels and thus has effects on the heart, lungs, and reproductive organs. It also causes bronchodilation, inhibits peristalsis in the intestines, and has diuretic effects. Most studies have been done on pharmacological effects when the drug is inhaled; the understanding of what methylhexanamine does when taken orally are mostly based on extrapolating from the activities of similar compounds.: 97 A 2013 review concluded that: "Pharmacological effects after oral intake can be expected on the lungs (bronchodilation) and the nasal mucosa following a single oral dose of about 4–15 mg. Pharmacological effects on the heart can be expected following a single oral dose of about 50–75 mg. Pharmacological effects on the blood pressure can be expected after a single oral dose of about 100 mg. Because of the long half-life, there is a risk that repeated doses within 24–36 hours could lead to steadily stronger pharmacological effects (build-up).": 98
Detection in body fluids
editMethylhexanamine may be quantified in blood, plasma, or urine by gas or liquid chromatography-mass spectrometry to confirm a diagnosis of poisoning in hospitalized patients or to provide evidence in a medicolegal death investigation. Blood or plasma methylhexanamine concentrations are expected to be in a range of 10–100 μg/L in persons using the drug recreationally, >100 μg/L in intoxicated patients, and >300 μg/L in victims of acute overdosage.[18][19]
Safety
editThe LD50 for methylhexanamine is 39 mg/kg in mice and 72.5 mg/kg in rats, when administered intravenously.: 95 [20]: 110
The FDA has stated that methylhexanamine "is known to narrow the blood vessels and arteries, which can elevate blood pressure and may lead to cardiovascular events ranging from shortness of breath and tightening in the chest to heart attack".[21] Numerous adverse events and at least five deaths have been reported in association with methylhexanamine-containing dietary supplements.[8] There have also been reports of secondary open-angle glaucoma related to methylhexanamine supplementation.[22]
A 2012 review by a panel convened by the U.S. Department of Defense to study whether the military should ban methylhexanamine supplements from stores on its bases concluded that: "The existing evidence does not conclusively establish that DMAA-containing substances are causally-associated with adverse medical events. However, a consistent theme among the studies is that DMAA use potentially affects cardiovascular function, just as other sympathomimetic stimulants. Without further rigorous study designs developed to evaluate the safety of DMAA, especially in patients with concomitant use of other substances, co-morbid conditions and high frequency use, the magnitude of the association of DMAA with adverse medical events is uncertain. Widespread use of DMAA-containing products by tens of thousands of Service members – often in combination with other substances – increases the likelihood of observing serious adverse events, even if the overall risk of a DMAA-related event is low, resulting in consequential impact to some Service members and other beneficiaries. DMAA should be further studied to evaluate its safety. Data from the case control study suggest that the frequency and amount of DMAA use and risk of specific [acquired medical events], particularly heat injuries and rhabdomyolysis, need to be examined in greater detail. ... The Safety Review Panel recommended ... to continue the prohibition of sales of DMAA-containing products in Exchanges and concessions. The Panel judged that the evidence supports sufficient risk, even if very low, of another death or catastrophic illness of a Service member who has used DMAA-containing products, without any offsetting benefit of these products."[11]: 10
Deaths and injuries
editIn 2010, a 21-year-old man in New Zealand presented with a cerebral hemorrhage after ingesting 556 mg of methylhexanamine, caffeine, and alcohol.[23] Health authorities in Hawaii linked cases of liver failure and one death to OxyElite Pro, a weight loss and bodybuilding dietary supplement.[24]
The death of Claire Squires, a runner who collapsed near the finish-line of the April 2012 London Marathon, has been linked to methylhexanamine. The coroner stated that methylhexanamine was "probably an important factor" during the inquest. Despite, according to a friend, having been diagnosed with an irregular heartbeat[25] and advised not to consume methylhexanamine, it is believed that she consumed the substance through drinking an energy drink, which was subsequently reformulated to exclude methylhexanamine.[26]
Regulation
editA number of sporting authorities and countries have banned or heavily restricted the use of methylhexanamine as a dietary supplement, due to serious concerns about its safety. These countries include Australia, Brazil, Canada, Finland, New Zealand, Sweden, Switzerland, the United Kingdom, and the United States.
Sports authorities
editMany professional and amateur sports bodies, such as the World Anti Doping Agency, have banned methylhexanamine as a performance-enhancing substance and suspended athletes that have used it.[27][28][29][30][31][32]
- March, 2012, a minor league baseball player, Cody Stanley, was suspended 50 games for testing positive after using a dietary supplement.[33]
- In July 2012, Welsh boxer Enzo Maccarinelli was banned for six months after testing positive for methylhexanamine.[34]
- VFL player Matthew Clark was suspended for two years after the banned substance was detected in his system after a game in 2011.[35]
- August, 2012, minor league baseball player Marcus Stroman was suspended 50 games for testing positive for methylhexanamine.[36]
- On 8 August 2013, US Weightlifter Brian Wilhelm accepted a nine-month suspension after testing positive for the drug in a urine sample from December 2012 at the American Open.[37]
- MotoGP rider Anthony West was suspended for one month by the FIM International Disciplinary Court (CDI) on 29 October 2012 after testing positive for the drug on 20 May 2012 at the French Grand Prix. This was increased retroactively to an 18-month suspension, starting from 20 May 2012, on 28 November 2013 after an appeal by the World Anti-Doping Agency (WADA).[38]
- In December 2013, boxer Brandon Rios, after losing a unanimous decision to Manny Pacquiao, was suspended by the China Professional Boxing Association after testing positive for the drug.[39]
- During the 2014 Winter Olympics in Sochi, three athletes tested positive for the drug: Italian bobsleigh brakeman and former decathlete William Frullani, German biathlete Evi Sachenbacher-Stehle and Latvian ice hockey forward Vitalijs Pavlovs.[40][41]
- During the 2015 Asian Cup, Iraqi player Alaa Abdul-Zahra was subject to an investigation relating to illegal usage of the drug.[42]
- In January 2016, Algerian footballer Kheiredine Merzougi was banned for two years by the Confederation of African Football after testing positive for the drug.[43] However, in March 2016, the international body FIFA confirmed they were giving an extended four-year ban to apply worldwide through January 2020.[44]
- In November 2016, heavyweight boxer Bermane Stiverne was fined US$75,000 after testing positive for methylhexanamine by the World Boxing Council.[45] The WBC, however, still allowed this fight to happen.
- In 2017, the International Olympic Committee disqualified Jamaica's 2008 gold-winning 4x100 men's relay in Beijing due to Nesta Carter's positive testing for methylhexanamine. This cost Usain Bolt a medal.[46]
- AMA Supercross Championship rider Broc Tickle was provisionally suspended by the FIM International Disciplinary Court (CDI) on 13 April 2018 after testing positive for the drug following a drug test after the supercross round held in San Diego on 10 February 2018.[47]
- On May 22, 2018, Filipino basketball player Kiefer Ravena was handed 18 months suspension by FIBA to compete in international competition. He was found testing positive for methylhexanamine and 1,3-dimethlybutylamine by WADA. Urine samples were taken after the Philippines vs Japan game at Manila during the 2019 FIBA Basketball World Cup Qualification. Ravena explained that he consumes a pre-workout drink called C4, which can be bought from retailers around Metro Manila. He ran out of supplies shortly before a training camp in Australia and took Blackstone Labs DUST, a supplement which is mixed with water and is supposedly similar to C4.[48]
- On August 26, 2019, NASCAR crew chief Matt Borland was indefinitely suspended under the sanctioning body's substance abuse policy after testing positive for DMAA. In a statement, Borland said that the positive test was most likely caused by a diet coffee he had felt comfortable drinking "after doing my due diligence." Team owner Bob Germain Jr. also said that he did not believe Borland “had reason to know that the coffee contained a banned substance. However, we also understand and respect NASCAR’s decisions to strictly uphold their policies for each and every owner, driver and crew member in the garage."[49] The suspension was lifted on September 24 after completing NASCAR's mandatory "Road to Recovery Program".[50]
Governmental agencies
editIn 2010, the US military issued a recall of all methylhexanamine-containing products from all military exchange stores worldwide.[51][52]
In July 2011, Health Canada decided methylhexanamine was not a dietary substance, but was a drug requiring further approval. Consequently, Health Canada banned all sales of methylhexanamine.[53]
In June 2012, the National Food Agency of Sweden issued a general warning regarding use of methylhexanamine products, resulting in a sales ban in parts of the country.[54]
In July 2012, the National Health Surveillance Agency of Brazil issued a warning to the general public on the hazards of products that contain methylhexanamine.[55] It also updated the list of prohibited substances to insert methylhexanamine, which translates into the banishment of products containing such ingredient from the Brazilian market.[56]
In 2012, Australia banned methylhexanamine. In New South Wales, methylhexanamine was classed as a "highly dangerous substance" on the poisons list.[57]
In August 2012, the UK Medicines and Healthcare products Regulatory Agency (MHRA) has ruled that the popular DMAA containing sports supplement Jack3D is an unlicensed medicinal product and that it and all other methylhexanamine containing products need to be removed from the UK market amid concerns of potential risks to public safety.[58]
In 2012 the New Zealand Ministry of Health banned the sale of methylhexanamine products,[59] due in part to its growing recreational use as party pills.[60][61]
In April 2013, the US Food and Drug Administration determined that methylhexanamine was potentially dangerous and did not qualify as a legal dietary supplement; it warned supplement makers that it was illegal to market methylhexanamine and warned consumers of potentially serious health risks associated with methylhexanamine-containing products.[8][62] The FDA has issued warning letters to manufacturers and distributors who continued to market products containing methylhexanamine.[63]
See also
editNotes
edit- ^ The N.D.A (New Drug Application) for methylhexanamine was withdrawn in 1983. Consequently, any product containing methylhexanamine cannot be marketed in the United States until a new application is approved.[4]
References
edit- ^ "DMAA: A prohibited stimulant". United States Department of Defense: Operation Supplement Safety. U.S. Department of Defense. October 12, 2022. Retrieved August 28, 2023.
- ^ "DMAA in Products Marketed as Dietary Supplements". United States Food and Drug Admistration. February 22, 2023. Retrieved August 28, 2023.
[Methylhexanamine] is not a dietary ingredient, and [Methylhexanamine]-containing products marketed as dietary supplements are illegal and their marketing violates the law.
- ^ "United States v. Hi-Tech Pharmaceuticals, Inc., No. 17-13376 (11th Cir. 2019)". Justia Law. August 30, 2019. Retrieved 2023-08-29.
DMAA is not an 'herb or other botanical.' It is not a 'constituent' of an herb or other botanical. And it is not generally recognized by qualified experts, as adequately shown through scientific procedures, to be safe under the conditions of its intended use.
- ^ Meyer, Harry (November 9, 1983). "E. R. Squibb & Sons, inc. et al.; Withdrawal of Approval of New Drug Applications" (PDF). Federal Register. U.S. Food and Drug Administration through the United States Government Publishing Office.
- ^ Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
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- ^ Cohen PA (July 2012). "DMAA as a dietary supplement ingredient". Archives of Internal Medicine. 172 (13): 1038–1039. doi:10.1001/archinternmed.2012.1677. PMID 22566490.
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- ^ a b Col John Lammie et al. Report of the Department Of Defense: 1,3 Dimethylamylamine (Dmaa) Safety Review Panel Archived 2014-01-19 at the Wayback Machine June 3, 2013
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- ^ Fleming HL, Ranaivo PL, Simone PS (2012). "Analysis and Confirmation of 1,3-DMAA and 1,4-DMAA in Geranium Plants Using High Performance Liquid Chromatography with Tandem Mass Spectrometry at ng/g Concentrations". Analytical Chemistry Insights. 7 (7): 59–78. doi:10.4137/ACI.S10445. PMC 3512447. PMID 23225994.
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- ^ "Methylhexaneamine Carbonate" entry in Marshall Sittig. Pharmaceutical Manufacturing Encyclopedia, Second Edition, Reprint Edition, Volume 1-2. 1988 Noyes Publications. Westwood, New Jersey.
- ^ Gee P, Tallon C, Long N, Moore G, Boet R, Jackson S (October 2012). "Use of recreational drug 1,3 Dimethylamylamine (DMAA) [corrected] associated with cerebral hemorrhage". Annals of Emergency Medicine. 60 (4): 431–434. doi:10.1016/j.annemergmed.2012.04.008. PMID 22575212.
- ^ Baselt RC (2014). Disposition of toxic drugs and chemicals in man, 10th edition. Seal Beach, Ca.: Biomedical Publications. p. 1329. ISBN 978-0-9626523-9-4.
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is known to narrow the blood vessels and arteries, which can elevate blood pressure and may lead to cardiovascular events ranging from shortness of breath and tightening in the chest to heart attack.
- ^ Balas M, Mathew DJ (March 2023). "Secondary open-angle glaucoma in a young male related to dimethylamylamine supplementation". Canadian Journal of Ophthalmology. Journal Canadien d'Ophtalmologie. 58 (4): e171–e175. doi:10.1016/j.jcjo.2023.02.011. PMID 36965509. S2CID 257710303.
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- ^ Kuehn BM (November 2013). "Dietary supplement linked to cases of acute hepatitis". JAMA. 310 (17): 1784. doi:10.1001/jama.2013.281868. PMID 24193065.
- ^ Wardrop M (May 2012), Claire Squires: runner who died during London Marathon 'suffered from heart condition', archived from the original on 2022-01-12
- ^ "Claire Squires inquest: DMAA was factor in marathon runner's death". BBC News. 30 January 2013. Retrieved 30 January 2013.
- ^ WADA 2010 Prohibited List (pdf) Archived 2013-09-11 at the Wayback Machine, World Anti-Doping Agency, Monday, 19 September 2009
- ^ "IAAF wait for Jamaica drug ruling". BBC Sport. BBC. August 11, 2009.
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- ^ "A long road back for catcher Cody Stanley". news-leader.com. Retrieved 27 March 2018.
- ^ "Enzo Maccarinelli handed six month drugs ban". BBC Sport. 2012-07-18. Retrieved 2012-07-18.
- ^ Wilson C (31 July 2013). "St Kilda's Ahmed Saad faces two-year drugs ban". Retrieved 27 March 2018 – via WA Today.
- ^ Lott J (August 28, 2012). "Jays prospect Marcus Stroman suspended 50 games for use of banned substance". The National Post. Archived from the original on April 11, 2013. Retrieved February 10, 2013.
- ^ "US Weightlifting Athlete, Wilhelm, Accepts Sanction For Anti-Doping Rule Violation". U.S. Anti-Doping Agency (USADA). 8 August 2013. Archived from the original on 1 February 2014.
- ^ McLaren P (28 November 2013). "Anthony West loses results after Anti-Doping appeal". Crash Media Group.
- ^ Ronnie Nathanielsz (December 16, 2013). "Brandon Rios is Suspended By CPBO Until April 24th". BoxingScene.com. Retrieved 2013-12-16.
- ^ "Evi Sachenbacher-Stehle and William Frullani sent home". BBC News. BBC. 21 February 2014. Retrieved 23 February 2014.
- ^ "Two athletes expelled for doping". ESPN. 22 February 2014. Retrieved 23 February 2014.
- ^ "Iran issue protest over ineligible Iraq player in Asian Cup quarter-final". www.persianfootball.com. Retrieved 27 March 2018.
- ^ Fodil H (3 February 2016). "Doping on Algeria's football pitches". alaraby. Retrieved 2016-03-22.
- ^ "FIFA extends three Algerian players' bans worldwide for four years". ESPNFC.com. 21 March 2016. Retrieved 2016-03-22.
- ^ "Bermane Stiverne tests positive for banned substance, fight Alexander Povetkin held". 2016-11-14. Retrieved 2016-12-15.
- ^ "Usain Bolt: Sprinter loses one Olympic gold over teammate's failed dope test - CNN". Retrieved 2017-01-25.
- ^ "Rider Broc Tickle provisionally suspended". www.fim-live.com.
- ^ "FIBA slaps 18-month ban on Ravena for doping violation". 2018-05-28. Archived from the original on 2018-05-29. Retrieved 2018-05-28.
- ^ "Dillon crew chief Borland suspended after failed drug test; cites diet coffee as possible cause". 2019-08-26.
- ^ "Crew chief Matt Borland reinstated after completing Road to Recovery Program". Archived from the original on 2019-10-06. Retrieved 2019-10-06.
- ^ "DMAA products pulled from base shelves". Retrieved 24 January 2013.
- ^ DMAA products pulled from base shelves – Military Off Duty, Army Health, military fitness, army physical fitness. Army Times. Retrieved on 2012-04-12.
- ^ Rovell D (2 May 2012). "DMAA Brands Start To Reformulate Products Without the Ingredient". CNBC. Archived from the original on January 19, 2013. Retrieved 1 August 2012.
- ^ "Varning för kosttillskott som innehåller DMAA". Archived from the original on 2012-08-04. Retrieved 2012-08-13.
- ^ "Anvisa alerta para risco de consumo de suplemento alimentar, July 2012". Brazilian Government: National Health Surveillance Agency (ANVISA). Archived from the original on 2 February 2013. Retrieved 22 January 2013.
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- ^ McNeilage A (1 August 2012). "Drug in workout drinks to be illegal". The Sydney Morning Herald. Retrieved 1 August 2012.
- ^ "Press release: MHRA to remove popular sports supplement used by international athletes from the market". Archived from the original on 2013-01-06. Retrieved 2013-01-30.
- ^ New Zealand Ministry of Health. Dunne announces Temporary Class Drug Notice March 8, 2012
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- ^ FDA Press Release. OxyElite Pro Dietary Supplements by USP Labs: Recall - Products Linked to Liver Illnesses November 10, 2013
External links
edit- "Stimulant Potentially Dangerous to Health, FDA Warns". U.S. Food and Drug Administration. April 11, 2013.
- Bussel II, Pavlov Jr AA (June 7, 2013). "DMAA: Efficacious but is it Safe?". Science Based Medicine Blog.