Distributive shock: Difference between revisions

The choice of fluids for resuscitation remains an area of research, the [[Surviving Sepsis Campaign]] an international consortium of experts, did not find adequate evidence to support the superiority of [[Volume expander#Crystalloids|crystalloid]] fluids versus [[Volume expander#Colloids|colloid]] fluids.{{sfn|Kanaparthi et al.|2013|loc= Treatment: Resuscitation}} Drugs such as, pyridoxalated hemoglobin polyoxyethylene, which scavenge nitric oxide from the blood, have been investigated.<ref name= "Kinasewitz 2008">{{cite journal |last1= Kinasewitz |first1= Gary T. |last2= Privalle |first2= Christopher T. |last3= Imm |first3= Amy |last4= Steingrub |first4= Jay S. |last5= Malcynski |first5= John T. |last6= Balk |first6= Robert A. |last7= DeAngelo |first7= Joseph |display-authors= 4 |date= July 2008 |title= Multicenter, randomized, placebo-controlled study of the nitric oxide scavenger pyridoxalated hemoglobin polyoxyethylene in distributive shock |journal= [[Critical Care Medicine]] |volume= 36 |issue= 7 |pages= 1999–2007 |doi= 10.1097/CCM.0b013e31817bfe84 |pmid= 18552688|s2cid= 30123186 }}</ref> As well as methylene blue which may inhibit the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway which has been suggested to play a significant role in distributive shock.<ref name= "Jang 2013">{{cite journal |last1= Jang |first1= D.H. |last2= Nelson |first2= L.S. |last3= Hoffman |first3= R.S. |date= September 2013 |title= Methylene blue for distributive shock: A potential new use of an old antidote |journal= [[Journal of Medical Toxicology]] |volume= 9 |issue=3 |pages= 242–9 |pmid= 23580172 |pmc= 3770994 |doi= 10.1007/s13181-013-0298-7}}</ref>