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End-plate potential: Difference between revisions

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|volume=115|issue= 3
|pages=543&ndash;556|pmid= 15036049|s2cid=43828995 }}</ref>
[[Lambert-EatonLambert–Eaton myasthenic syndrome]] is a disorder where presynaptic calcium channels are subjected to autoimmune destruction which causes fewer neurotransmitter vesicles to be exocytosed. This causes smaller EPPs due to less vesicles being released. Often the smaller EPPs do not reach threshold which causes muscle weakness and fatigue in patients.
Many animals use neurotoxins to defend themselves and kill prey. [[Tetrodotoxin]] is a poison found in the certain poisonous fishes such as [[pufferfish]] and [[triggerfish]] which blocks the sodium ion channels and prevents an action potential on the postsynaptic membrane. [[Tetraethylammonium]] found in insects blocks potassium channels. Alpha neurotoxin found in snakes binds to acetylcholine receptors and prevents acetylcholine from binding. [[Alpha-latrotoxin]] found in [[Latrodectus|black widow spiders]] causes a massive influx of calcium at the axon terminal and leads to an overflow of neurotransmitter release.
[[Botulinum toxin]] produced by the bacteria [[Clostridium botulinum]] is the most powerful toxic protein. It prevents release of acetylcholine at the neuromuscular junction by inhibiting docking of the neurotransmitter vesicles.