Hypokalemic periodic paralysis: Difference between revisions

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'''Hypokalemic periodic paralysis''' (hypoKPP) is a rare, [[autosomal dominant]] [[channelopathy]] characterized by muscle weakness or paralysis when there is a fall in [[potassium]] levels in the [[blood]]. In individuals with this mutation, attacks often begin in [[adolescence]] and most commonly occur on awakening or after sleep or rest following strenuous exercise (attacks during exercise are rare), high [[carbohydrate]] meals, meals with high [[sodium]] content, sudden changes in temperature, and even excitement, noise, flashing lights and cold temperatures. Weakness may be mild and limited to certain muscle groups, or more severe full-body paralysis. During an attack reflexes may be decreased or absent. Attacks may last for a few hours or persist for several days. Recovery is usually sudden when it occurs, due to release of potassium from swollen muscles as they recover. Some patients may fall into an abortive attack or develop chronic muscle weakness later in life.

 

==References==

 

*National Library of Medicine. [http://ghr.nlm.nih.gov/condition=hypokalemicperiodicparalysis?wf=1 Hypokalemic periodic paralysis]

 

== External links ==

* [https://www.ncbi.nlm.nih.gov/books/NBK1338/ GeneReview/NIH/UW entry on Hypokalemic Periodic Paralysis]