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Mutations in [[KCNJ2]] lead to hypokalemic periodic paralysis with cardiac arrhythmias called [[Andersen–Tawil syndrome]].{{citation needed}}
In contrast, [[hyperkalemic periodic paralysis]] refers to gain-of-function mutations in sodium channels that maintain muscle depolarisation and therefore are aggravated by high potassium ion concentrations.{{citation needed}}
This condition is inherited in an [[autosomal dominant]] pattern (but with a high proportion of sporadic cases), which means one copy of the altered gene in each cell is sufficient to cause the disorder.
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