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There are seven subfamilies of K<sub>ir</sub> channels, denoted as K<sub>ir</sub>1 – K<sub>ir</sub>7.<ref name="Kubo"/> Each subfamily has multiple members (i.e. K<sub>ir</sub>2.1, K<sub>ir</sub>2.2, K<sub>ir</sub>2.3, etc.) that have nearly identical amino acid sequences across known mammalian species.
K<sub>ir</sub> channels are formed from as [[homotetrameric]] membrane proteins. Each of the four identical protein subunits is composed of two membrane-spanning [[alpha helix|alpha helices]] (M1 and M2). Heterotetramers can form between members of the same subfamily (i.e. K<sub>ir</sub>2.1 and K<sub>ir</sub>2.3) when the channels are overexpressed.
===Diversity===
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