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'''Miroestrol''' is a [[phytoestrogen]], a plant-derived chemical that mimics the biological activity of the hormone [[estrogen]]. Miroestrol was first reportedly isolated from the Thai herb ''[[Pueraria mirifica]]'' in 1960 and thought to be responsible for the supposed rejuvenating properties of the plant.<ref>{{cite journal | title = Miroestrol-estrogen from the plant Pueraria mirifica | author = Cain, James C. | journal = Nature | year = 1960 | volume = 188 | pages = 774–7 | doi = 10.1038/188774a0}}</ref> However, more recent studies have suggested that the active ingredient may actually be the closely related chemical compound deoxymiroestrol, and the reported pretense of miroestrol may only have been an artifact of the isolation procedure.<ref>{{cite journal | author = Chansakaow, Sunee; Ishikawa, Tsutomu; Seki, Hiroko; Sekine, Keiko; Okada, Mineaki; Chaichantipyuth, Chaiyo | title = Identification of deoxymiroestrol as the actual rejuvenating principle of "Kwao
A comparative study of the estrogenic properties of phytoestrogens found that deoxymiroestrol was similar in activity to other known phytoestrogens, such as [[coumestrol]], but that miroestrol was significantly less active.<ref>{{cite journal | title = Comparative study of estrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells | author = Matsumura, A.; Ghosh, A.; Pope, G. S.; Darbre, P. D. | journal = Journal of Steroid Biochemistry and Molecular Biology |year = 2005 | volume = 94 | issue = 5 | pages = 431–443 | doi = 10.1016/j.jsbmb.2004.12.041}}</ref> Because of their estrogenic activities, miroestrol, deoxymiroestrol, and other related compounds have been the targets of scientific research including [[total synthesis]].<ref>{{cite journal | author = [[Elias James Corey|Corey, E. J.]]; Wu, Laurence I. | title = Enantioselective total synthesis of miroestrol | journal = [[Journal of the American Chemical Society]] | year = 1993 | volume = 115 | issue = 20 | pages = 9327–8 | doi = 10.1021/ja00073a074}}</ref><ref>{{cite journal | author = Ito, Fumihiro; Kumamoto, Takuya; Yamaguchi, Kentaro; Ishikawa, Tsutomu | title = Synthetic studies toward miroestrols: trials for elongation of the methyl group of 5-substituted 2-methyl-2-cyclohexanone to 3-methyl-2-butenyl function | journal = Tetrahedron | year = 2009 | volume = 65 | issue = 4 | pages = 771–785 | doi = 10.1016/j.tet.2008.11.055}}</ref>
Extracts of ''[[Pueraria mirifica]]'' reportedly containing miroestrol are marketed as dietary supplements intended to lead to breast enhancement in women. However, there is no scientific basis for such claims. The [[Federal Trade Commission]] has taken legal action against marketers for these
The research around Pueraria Mirifica and Miroestrol was conducted by Jones & Pope back in 1960 and are until today still researched upon in several countries due to its positive effects on human health <ref>Miroestrol research document, ''[http://www.anne-selene.com/downloads/MiroHealthResearch.pdf Miroestrol research]''</ref>
Miroestrol
[[File:Deoxymiroestrol.png|thumb|left|Chemical structure of deoxymiroestrol]]{{clear-left}}
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