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Line 1: '''Neurogenic inflammation''' is [[inflammation]] arising from the local release from [[sensory neuron\|afferent neurons]] of [[inflammation\|inflammatory]] mediators such as [[Substance P]], [[calcitonin gene-related peptide\|Calcitonin Gene-Related Peptide (CGRP)]], [[neurokinin A]] (NKA), and [[endothelin-3]] (ET-3).<ref>{{cite journal\|last1=Peroutka\|first1=Stephen J.\|title=Neurogenic inflammation and migraine: implications for the therapeutics\|journal=Molecular Interventions (Mol Interv.)\|date=October 2005\|volume=5\|issue=5\|pages=304-311\|doi=10.1124/mi.5.5.10\|pmid=16249526\|url=http://triggered.edina.clockss.org/ServeContent?rft_id=info:doi/10.1124/mi.5.5.10\|accessdate=21 September 2014}}</ref><ref>{{cite journal\|last1=Chen\|first1=Ying\|last2=Lyga\|first2=John\|title=Brain-Skin Connection: Stress, Inflammation and Skin Aging\|journal=Inflamm Allergy Drug Targets\|date=Jun 2014\|volume=13(3)\|issue=Jun 2014\|page=177–190.\|doi=10.2174/1871528113666140522104422\|pmid=24853682\|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082169\|accessdate=7 August 2014}}</ref><ref>{{cite journal \| pmid = 18307678 \| doi=10.1111/j.1464-410X.2008.07493.x \| volume=101 Suppl 3 \| title=The concept of neurogenic inflammation \|date=March 2008 \| journal=BJU Int. \| pages=2–6}}</ref> This process appears to play an important role in the [[pathogenesis]] of numerous diseases including [[migraine]],<ref>{{cite journal \| pmid =18545913 \| last1 =Frediani \| year =2008 \| first1 =F \| pages =S127–30 \| last2 =Villani \| volume =29 Suppl 1 \| journal =Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology \| first2 =V \| last3 =Casucci \| first3 =G \|title=Peripheral mechanism of action of antimigraine prophylactic drugs \| doi =10.1007/s10072-008-0903-8}}</ref><ref>{{cite journal \| doi=10.1124/mi.5.5.10 \| last1=Peroutka \| first1=SJ \| title=Neurogenic inflammation and migraine: implications for the therapeutics \| pmid= 16249526 \| year=2005 \| pages=304–11 \| issue=5 \| volume=5 \| journal=Molecular interventions \|url= http://molinterv.aspetjournals.org/content/5/5/304.long }}</ref><ref>{{cite journal \| last1=Geppetti \| first1=P \| last2=Capone \| first2=JG \| last3=Trevisani \| first3=M \| last4=Nicoletti \| first4=P \| last5=Zagli \| first5=G \| last6=Tola \| first6=MR \| title=CGRP and migraine: neurogenic inflammation revisited \| journal=The journal of headache and pain \| volume=6 \| issue=2 \| pages=61–70 \| year=2005 \| pmid=16362644 \| doi=10.1007/s10194-005-0153-6 \| pmc=3452316}}</ref> [[psoriasis]],<ref>{{cite journal\|last1=Chen\|first1=Ying\|last2=Lyga\|first2=John\|title=Brain-Skin Connection: Stress, Inflammation and Skin Aging\|journal=Inflamm Allergy Drug Targets\|date=Jun 2014\|volume=13(3)\|issue=Jun 2014\|page=177–190.\|doi=10.2174/1871528113666140522104422\|pmid=24853682\|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082169\|accessdate=7 August 2014}}</ref><ref>Schön and Boehncke, [http://content.nejm.org/cgi/content/full/352/18/1899 Psoriasis: Neurogenic inflammation and other mechanisms] NEJM 352:1899-1912, Number 18, 2005</ref><ref>{{cite journal \| pmid= 17034513 \| last1= Saraceno \| first1= R \| year= 2006 \| pages= 876–82 \| issue= 5 \| last2= Kleyn \| volume= 155 \| first2= CE \| journal= The British journal of dermatology \| last3= Terenghi \| first3= G \| last4= Griffiths \| first4= CE \|title=The role of neuropeptides in psoriasis \| doi= 10.1111/j.1365-2133.2006.07518.x}}</ref> [[asthma]],<ref>{{cite journal \| pmid = 11829413 \| volume=22 \| issue=6 \| title=Neurogenic inflammation and particulate matter (PM) air pollutants \|date=December 2001 \| journal=Neurotoxicology \| pages=795–810 \| doi = 10.1016/S0161-813X(01)00062-6 \| last1 = Verones \| first1 = B \| last2 = Oortgiesen \| first2 = M}}</ref> [[fibromyalgia]], [[eczema]], [[rosacea]], [[dystonia]], and [[multiple chemical sensitivity]],.<ref>{{cite journal \| pmid = 19801154 \| doi=10.1016/j.jns.2009.09.003 \| volume=287 \| issue=1–2 \| title=Brain dysfunction in multiple chemical sensitivity \|date=December 2009 \| journal=J. Neurol. Sci. \| pages=72–8 \| last1 = Orriols \| first1 = Ramon \| last2 = Costa \| first2 = Roser \| last3 = Cuberas \| first3 = Gemma \| last4 = Jacas \| first4 = Carlos \| last5 = Castell \| first5 = Joan \| last6 = Sunyer \| first6 = Jordi}}</ref><ref>{{cite journal \| last1= Bascom \| first1= R \| last2= Meggs \| first2= WJ \| last3= Frampton \| first3= M \| last4= Hudnell \| first4= K \| last5= Killburn \| first5= K \| last6= Kobal \| first6= G \| last7= Medinsky \| first7= M \| last8= Rea \| first8= W \| title= Neurogenic inflammation: with additional discussion of central and perceptual integration of nonneurogenic inflammation \| journal= Environmental health perspectives \| volume= 105 Suppl 2 \| pages= 531–7 \| pmc= 1469802 \| year= 1997 \| pmid = 9167992 \| doi=10.2307/3433365}}</ref> and [[migraine]].<ref>{{cite journal \| pmid =18545913 \| last1 =Frediani \| year =2008 \| first1 =F \| pages =S127–30 \| last2 =Villani \| volume =29 Suppl 1 \| journal =Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology \| first2 =V \| last3 =Casucci \| first3 =G \|title=Peripheral mechanism of action of antimigraine prophylactic drugs \| doi =10.1007/s10072-008-0903-8}}</ref><ref>{{cite journal \| doi=10.1124/mi.5.5.10 \| last1=Peroutka \| first1=SJ \| title=Neurogenic inflammation and migraine: implications for the therapeutics \| pmid= 16249526 \| year=2005 \| pages=304–11 \| issue=5 \| volume=5 \| journal=Molecular interventions \|url= http://molinterv.aspetjournals.org/content/5/5/304.long }}</ref><ref>{{cite journal \| last1=Geppetti \| first1=P \| last2=Capone \| first2=JG \| last3=Trevisani \| first3=M \| last4=Nicoletti \| first4=P \| last5=Zagli \| first5=G \| last6=Tola \| first6=MR \| title=CGRP and migraine: neurogenic inflammation revisited \| journal=The journal of headache and pain \| volume=6 \| issue=2 \| pages=61–70 \| year=2005 \| pmid=16362644 \| doi=10.1007/s10194-005-0153-6 \| pmc=3452316}}</ref> In [[migraine]], stimulation of the [[trigeminal nerve]] causes neurogenic inflammation via release of neuropeptides including [[Substance P]], [[nitric oxide]], [[vasoactive intestinal polypeptide]], [[5-HT]], [[Neurokinin A]] and [[CGRP]].<ref>{{cite journal \|last1=Arun A Kalra \|first1=AA\|last2= Debra Elliott \|first2=D\|title=Acute migraine: Current treatment and emerging therapies \|journal= Ther Clin Risk Manag\|volume= 3\|issue= 3\|pages= 449–459 \|publisher= Dove Medical Press Limited \|date=June 2007 \|pmc=2386351 \|pmid=18488069}}</ref><ref>{{cite journal \|doi=10.1007/s10194-008-0011-4 \|last1=Andrea Stephanie Link \|first1=AS\|last2= Anikó Kuris et. al \|first2=A \|last3=Edvinsson \|first3=L\|title=Treatment of migraine attacks based on the interaction with the trigemino-cerebrovascular system \|journal= J Headache Pain\|volume= 9\|issue= 1\|pages= 5–12\|publisher= Biomedical Center Lund \|date=23 January 2008 \|pmc=2245994 \|pmid=18217201}}</ref> leading to a "sterile neurogenic inflammation."<ref>Werner Grossmann, MD, and Hanns Schmidramsl, MD

Neurogenic inflammation: Difference between revisions