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It has been suggested that [[Inflammation|proinflammatory]] processes may have a role in somatic symptom disorder, such as an increase of non-specific somatic symptoms and sensitivity to painful [[Stimulus (physiology)|stimuli]].<ref name=proinflammatory>{{cite journal|first1=Winfried|last1=Rief|first2=Anika|last2=Hennings|first3=Sabine|last3=Riemer|first4=Frank|last4=Euteneuer|title=Psychobiological differences between depression and somatization|url=https://pubmed.ncbi.nlm.nih.gov/20403510/|journal=Journal of Psychosomatic Research|date=May 2010|issn=1879-1360|pages=495–502|volume=68|issue=5|pmid=20403510|doi=10.1016/j.jpsychores.2010.02.001}}</ref> [[Inflammation|Proinflammatory]] activation and [[anterior cingulate cortex]] activity have been shown to be linked in those who experienced stressful life events for an extended period of time. It is further claimed that increased activity of the [[anterior cingulate cortex]], which acts as a bridge between attention and emotion, leads to increased sensitivity of unwanted [[Stimulus (physiology)|stimuli]] and bodily sensations.<ref name=cingulate>{{cite journal|first1=Neil A.|last1=Harrison|first2=Lena|last2=Brydon|first3=Cicely|last3=Walker|first4=Marcus A.|last4=Gray|title=Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity|journal=Biological Psychiatry|date=1 September 2009|issn=1873-2402|pages=407–414|volume=66|issue=5|pmid=19423079|pmc=2885494|doi=10.1016/j.biopsych.2009.03.015|first5=Andrew|last5=Steptoe|first6=Hugo D.|last6=Critchley}}</ref>
[[Pain]] is a multifaceted experience, not just a sensation. While [[nociception]] refers to afferent [[Neurotransmission|neural activity]] that transmits [[Sense|sensory information]] in response to [[Stimulus (physiology)|stimuli]] that may cause [[Tissue (biology)|tissue damage]], [[pain]] is a conscious experience requiring [[Cerebral cortex|cortical]] activity and can occur in the absence of [[nociception]].<ref name=biosocial/> Those with somatic symptoms are thought to [[Exaggeration|exaggerate]] their somatic symptoms through choice perception and perceive them in accordance with an [[Disease|ailment]]. This idea has been identified as a [[Cognition|cognitive]] style known as "somatosensorial amplification."<ref name=somatosensorialamplification>{{cite journal|first1=A. J.|last1=Barsky|title=Amplification, somatization, and the somatoform disorders|journal=Psychosomatics |date=1992 |url=https://pubmed.ncbi.nlm.nih.gov/1539100/|issn=0033-3182|pages=28–34|volume=33|issue=1|pmid=1539100|doi=10.1016/S0033-3182(92)72018-0}}</ref> The term "[[central sensitization]]" has been created to describe the [[Neuroscience|neurobiological]] notion that those predisposed to somatization have an overly sensitive [[neural network]]. Harmless and mild [[Stimulus (physiology)|stimuli]] stimulate the [[Nociception|nociceptive]] specific [[
===Genetic===
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