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===Antibiotics===
In severe sepsis, broad spectrum antibiotics are recommended within 1 hour of making the diagnosis.<ref name=Campaign2008/> For every hour delay in the administration there is an associated 6% rise in mortality.<ref name=Soong2012/> DurationAntibiotic ofregimens treatmentshould isbe typicallyreassessed 7-10 daily and narrowed if appropriate.<ref name="Surviving Sepsis 2012">{{cite journal|last=Dellinger|first=RP|coauthors=Levy, MM;days withRhodes, theA; typeAnnane, ofD; antibioticGerlach, usedH; directedOpal, bySM; Sevransky, JE; Sprung, CL; Douglas, IS; Jaeschke, R; Osborn, TM; Nunnally, ME; Townsend, SR; Reinhart, K; Kleinpell, RM; Angus, DC; Deutschman, CS; Machado, FR; Rubenfeld, GD; Webb, SA; Beale, RJ; Vincent, JL; Moreno, R; Surviving Sepsis Campaign Guidelines Committee including the resultsPediatric, Subgroup|title=Surviving sepsis campaign: international guidelines for management of culturessevere sepsis and septic shock: 2012.<ref|journal=Critical namecare medicine|date=Campaign20082013 Feb|volume=41|issue=2|pages=580-637|pmid=23353941}}</ref>
Duration of treatment is typically 7-10 days with the type of antibiotic used directed by the results of cultures.<ref name=Campaign2008/>
===Early goal directed therapy===
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