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Unlike caffeine, which is highly water-soluble, theobromine is only slightly water-soluble and is more fat soluble, and thus peaks more slowly in the blood. While caffeine peaks after only 30 minutes, theobromine requires 2–3 hours to peak.<ref>{{cite journal | vauthors = Mumford GK, Benowitz NL, Evans SM, Kaminski BJ, Preston KL, Sannerud CA, Silverman K, Griffiths RR | title = Absorption rate of methylxanthines following capsules, cola and chocolate | journal = European Journal of Clinical Pharmacology | volume = 51 | issue = 3–4 | pages = 319–325 | date = 1 December 1996 | pmid = 9010706 | doi = 10.1007/s002280050205 | s2cid = 8405909 }}</ref>
The primary mechanism of action for theobromine inside the body is inhibition of [[adenosine]] receptors.<ref name=Hbk/> Its effect as a [[phosphodiesterase inhibitor]]<ref name="PDEs-Essayan">{{cite journal | vauthors = Essayan DM | title = Cyclic nucleotide phosphodiesterases | journal = The Journal of Allergy and Clinical Immunology | volume = 108 | issue = 5 | pages = 671–680 | date = November 2001 | pmid = 11692087 | doi = 10.1067/mai.2001.119555 | doi-access = free }}</ref> is thought to be small.<ref name=Hbk/>
==Effects==
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