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The synonyms used for dendritic cells have shifted over the years. "DC1" used to refer to conventional dendritic cells, and "DC2" used to refer to plasmacytoid dendritic cells. These are the synonyms that were captured in curation of the CL probably over a decade ago. In recent years, different groups have started using DC1 and DC2 to refer to subtypes of conventional dendritic cells. See issues #1026 and #1027 as well as #838 and #839.
As mentioned in earlier issues, we need to do a review of the dendritic cells to bring the representation in line with the current literature. I would like to do this, but have not found the time yet.
I am taking a look at duplicate CL mappings on Wikidata and stumbled upon this:
conventional dendritic cell
Go to external page http://purl.obolibrary.org/obo/CL_0000990
has exact synonym
DC1
cDC
type 1 DC
dendritic reticular cell
Is that correct?
It seems like "cDC" is a conceptually broader term (e.g. https://www.nature.com/subjects/myeloid-dendritic-cells) with some resources mentioning Type 2 CDCs (e.g. PMC9028336.
Maybe @addiehl can weigh in on that
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