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Oligodendrocytes incorrectly classed as oligodendrocyte precursor cell #55

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aleixpuigb opened this issue Apr 25, 2024 · 2 comments
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@aleixpuigb
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aleixpuigb commented Apr 25, 2024

Jeremy Miller has identified 3 cells that are classed as oligodendrocyte precursor cell (OPC), but are not. All terms that start with oligo are oligodendrocyte, while terms that start with OPC are oligodendrocyte precursor cells (Bakken et al., 2021 Nature DOI:10.1038/s41586-021-03465-8):

image

Primates had a unique oligodendrocyte population (Oligo SLC1A3 LOC103793418 in marmosets and Oligo L2-6 OPALIN MAP6D1 in humans) that was not a distinct cluster in mice

  • Oligo L2-6 OPALIN MAP6D1 primary motor cortex oligodendrocyte precursor cell (Hsap) PCL:0015079
image
  • Oligo L2-6 OPALIN FTH1P3 primary motor cortex oligodendrocyte precursor cell (Hsap) PCL:0015120

  • Oligo L3-6 OPALIN-like ENPP6 primary motor cortex oligodendrocyte precursor cell (Hsap) PCL:0015119

We need to change the parent term to oligodendrocyte (CL:0000128) and relabel them (remove precursor cell).

@hkir-dev hkir-dev self-assigned this Apr 25, 2024
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Probably easiest solution is to add CL:0000128 Classifications for those three cells in the related curation table: https://github.com/obophenotype/brain_data_standards_ontologies/blob/master/src/patterns/data/default/CCN201912131_class_curation.tsv
We are working on a BDSO and PCL release related with issue #54. All these changes can be rolled together.

@aleixpuigb
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Thank you Huseyin!

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