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The Generic Modeling Environment (GME) is a configurable toolset that supports the easy creation of domain-specific modeling and program synthesis environments. The primarily graphical, domain-specific models can represent the application and its environment including hardware resources, and their relationship. The models are then used to automatically synthesize the application and/or generate inputs to COTS analysis tools. In addition to traditional signal processing problems, we have applied this approach to tool integration and structurally adaptive systems among other domains. This paper describes the GME toolset and compares it to other similar approaches. A case study is also presented that illustrates the core concepts through an example.