Gryfino County (Polish: powiat gryfiński) is a unit of territorial administration and local government (powiat) in West Pomeranian Voivodeship, north-western Poland, on the German border. It came into being on January 1, 1999, as a result of the Polish local government reforms passed in 1998. Its administrative seat and largest town is Gryfino, which lies 20 kilometres (12 mi) south of the regional capital Szczecin. The county contains five other towns: Chojna, 32 km (20 mi) south of Gryfino, Mieszkowice, 52 km (32 mi) south of Gryfino, Trzcińsko-Zdrój, 33 km (21 mi) south of Gryfino, Cedynia, 45 km (28 mi) south-west of Gryfino, and Moryń, 44 km (27 mi) south of Gryfino.

The county covers an area of 1,869.54 square kilometres (721.8 sq mi). As of 2006 its total population is 82,813, out of which the population of Gryfino is 21,478, that of Chojna is 7,187, that of Mieszkowice is 3,553, that of Trzcińsko-Zdrój is 2,496, that of Cedynia is 1,653, that of Moryń is 1,570, and the rural population is 44,876.

Gryfino [ɡrɨˈfʲinɔ] (German: Greifenhagen; Kashubian: Gripiewò; Pomeranian Low German: Gripenhagen) is a town in Pomerania, northwestern Poland with 22,500 inhabitants (2004). It is also the capital of Gryfino County in West Pomeranian Voivodeship (since 1999), previously in Szczecin Voivodeship (1975–1998).

Before 1945 the area was part of Germany. After World War II the region was placed under Polish administration and ethnically cleansed according to the post-war Potsdam Agreement. The native German populace was expelled and replaced with Poles. For the history of the region, see History of Pomerania.

The town is located on the Odra Wschodnia (Reglitz), the eastern branch of the Oder river, about 20 kilometres (12 miles) south of the Pomeranian capital Szczecin (Stettin). The western branch of the Oder, 2 km (1 mi) away from the town center, has marked the border with Germany since 1945. There is a straight road link between Gryfino and the German town of Mescherin across the two rivers.