Ethe may refer to

Protein ETHE1, mitochondrial , also known as "ethylmalonic encephalopathy 1 protein" and "per sulfide dioxygenase", is a protein that in humans is encoded by the ETHE1 gene located on chromosome 19.

Structure

The human ETHE1 gene consists of 7 exons and encodes for a protein that is approximately 27 kDa in size.

Function

This gene encodes a protein that is expressed in the thyroid.

The ETHE1 protein is thought to localize primarily to the mitochondrial matrix and functions as a sulfur dioxygenase. Sulfur deoxygenates are proteins that function in sulfur metabolism. The ETHE1 protein is thought to catalyze the following reaction:

Sulfur + O2 + H2O = sulfite + 2 H+.

and requires iron and possibly glutathione as co-factors. The physiological substrate of ETHE1 is thought to be glutathione persulfide, an intermediate metabolite involved in hydrogen sulfide degradation.

Clinical significance

Mutations in ETHE1 gene are thought to cause ethylmalonic encephalopathy, a rare inborn error of metabolism. Patients carrying ETHE1 mutations have been found to exhibit lower activity of ETHE1 and affinity for the ETHE1 substrate. Mouse models of Ethe1 genetic ablation likewise exhibited reduced sulfide dioxygenase catabolism and cranial features of ethylmalonic encephalopathy. Decrease in sulfide dioxygenase activity results in abnormal catabolism of hydrogen sulfide, an gas-phase signaling molecule in the central nervous system, whose accumulation is thought to inhibit cytochrome c oxidase activity in the respiratory chain of the mitochondrion. However, other metabolic pathways may also be involved that could exert a modulatory effect on hydrogen sulfide toxicity.

Rheine-Bentlage Air Base (German: Heeresflugplatz Rheine-Bentlage, IATA: ZPQ, ICAO: ETHE) is located near the village of Bentlage, 2 km northwest of the city of Rheine, North Rhine-Westphalia, Germany.

In 1939 works to build an air base for the Luftwaffe began. These works were completed in 1940. During World War II extensive use was made of the air base, particularly by night and day fighter squadrons. After the war the air base was abandoned.

In 1960, following the founding of the German Armed Forces in 1955 and the establishing of a new branch within the German Army, the Aviation Corps, completely new military installations, hangars and a small runway made of asphalt, were constructed on the grounds of the former German Air Force base.

Since 1960 various units of the German Army Aviation Corps have been stationed at Rheine Air Base. Initially, these units flew helicopters of the type Sikorsky H-34 which were used extensively during the relief operation following the disastrous North Sea flood of 1962. Another type of helicopter that was stationed in this period at Rheine Air Base was the Alouette II.