The KFC Yum! Center is a large multi-purpose sports arena in Downtown Louisville, Kentucky. It is named after the KFC restaurant chain and Yum! Brands, the parent company of KFC. Adjacent to the Ohio River waterfront, it is located on Main Street between 2nd and 3rd Streets and opened on October 10, 2010. The arena is part of a $450 million project that includes a 975-car parking structure and floodwall.

The University of Louisville Cardinals men's and women's basketball teams are the primary tenants of the arena complex. The U of L women's volleyball team began using the arena as a part-time home in 2011, and made the arena its main home in 2012. It is the second-largest college arena in the Commonwealth (behind only Kentucky's Rupp Arena) and the third-largest in the nation (behind only Syracuse's Carrier Dome and Rupp Arena). The arena's current attendance record is 22,815, set March 9, 2013 against Notre Dame.

Since its opening, the KFC Yum! Center has been a frequent spot for major concerts.