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Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 is a protein that in humans is encoded by the HCN1 gene.

Function

Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.

Tissue distribution

HCN1 channel expression is found in the sinoatrial node, the neocortex, hippocampus, cerebellar cortex, dorsal root ganglion, trigeminal ganglion and brainstem.

Interactions

HCN1 has been shown to interact with HCN2.

Epilespy

De novo mutations in HCN1 cause epilepsy .

See also

References

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the HCN4 gene.

There are four HCN channels. HCN4 is prominently expressed in the pace maker region of the mammalian heart. Some humans with bradycardia and Sick sinus syndrome have been shown to have mutations in their HCN4 gene. The role of HCN channels in autonomic control of heart rate is currently a matter of ongoing investigation.

Interactions

HCN4 has been shown to interact with HCN2.

See also

References

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.