Lucida Grande is a humanist sans-serif typeface. It is a member of the Lucida family of typefaces designed by Charles Bigelow and Kris Holmes. It has been used throughout Mac OS X user interface from 1999 to 2014, as well as in Safari for Windows up to the browser's version 3.2.3 released on 12 May 2009. As of OS X 10.10 Yosemite, the system font was changed from Lucida Grande to Helvetica Neue. In OS X El Capitan the system font changed again, this time to San Francisco (2014 typeface).

The typeface looks very similar to Lucida Sans and Lucida Sans Unicode. Like Sans Unicode, Grande supports the most commonly used characters defined in version 2.0 of the Unicode standard.

Three weights of Lucida Grande: Normal, Bold, and Black, in three styles: Roman, Italic, and Oblique, were developed by Bigelow & Holmes. Apple released the Regular (Normal Roman) and Bold Roman with OS X.

In June, 2014, Bigelow & Holmes released four weights: Light, Normal, Bold, and Black, in three styles: Roman, Italic, and Oblique. B&H also released Narrow versions of those twelve weight/styles, plus four Lucida Grande Monospaced fonts in Regular, Bold, Italic, and Bold Italic styles, with narrow versions of the four monospaced weight/styles.