Mike Domenik Rinderknecht’s Post

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PhD, Data Scientist | Digital Biomarkers, Digital Therapeutics, Real-World Evidence

How can we make a new #DigitalHealth solution, or new #digital measures, fit for real-word use? One key requirement is a well-designed study that addresses pertinent research questions related to the robustness and validity of the digital measures; the disease concepts that they capture; how they translate from a laboratory setting to a real-world setting. To address these research questions, we have designed a clinical study that simultaneously collects sensor-based gait and balance data from smartphones and reference measurement systems (IMUs, a motion capture system, force plates, and/ or video recordings), with data collected in both a laboratory and remote, real-world setting. Combined with a rich set of patient-reported outcomes, this dataset will enable us to investigate the impact of real-world confounders on our digital measures (e.g., how does the on-body location of the smartphone affect the digital measures); allow us to explore their validity, robustness, and consistency; and aid in their interpretation. We are pleased to share with you the protocol of this study, which has been recently published in Digital Health https://lnkd.in/eC_EStMN! We look forward to sharing with you in future our findings from this study and from our continued effort of shaping the future of digital health in #MultipleSclerosis. I’d like to thank my colleagues and co-authors without whom this work would not have been possible: Mattia Zanon, Tjitske Boonstra, Lorenza Angelini, Dimitar Stanev, Gabriela Chan, Lisa Bunn, Frank Dondelinger, Richard Hosking, Jenny Freeman, Jeremy Hobart, Jonathan Marsden, Licinio Craveiro #smartphone #gait #balance #ClinicalTrial #sensors

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Cléo Moulin

Clinical Innovation Manager at MindMaze

8mo

With this ambitious clinical study, your team is contributing to build a new paradigm: a future healthcare system where appropriate digital biomarkers enable personalized and efficient care for people with Multiple Sclerosis. Well done!

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