A group of researchers did their part to #EndAlz by characterizing the epigenomic, genomic, transcriptomic, and cellular underpinnings of #Alzheimers disease at the #singlecell level. See how they did it in our new blog, and spread the word for #AlzheimersAwareness month!
10x Genomics’ Post
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Welcome to Club Xenium! 🎉
Finally, the 10x Genomics Xenium Analyser is all installed and ready to run! It was an unexpected but happy surprise to receive the grant last year. Being closely involved in the process from the beginning was a great experience for my personal and professional development. Thank you Rebecca Mitchell and Monika Dabrowska, for the training. Special thanks to Noel Harris-Brown for getting the machine installed and running smoothly, and also to the team in the School of Clinical Dentistry. The greatest thanks and gratitude to Prof Dan Lambert for involving me in this incredible journey! 👨🔬 I'm excited to see the next steps and anticipate lots of cutting-edge research output at The University of Sheffield. Please contact the email below for more information on facility access: spatial-imaging@sheffield.ac.uk
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Amazing discoveries happen when new technologies allow talented researchers to tackle the questions whose answers were previously inaccessible. For example, the D’Souza lab took advantage of the single cell spatial resolution of Xenium In Situ to understand the complex spatial regulation of cleft palate formation. Their findings could fuel the discovery of potential in utero and early postnatal therapeutic targets for correcting cleft palate anomalies, which affects ~1 in every 700 live births annually. Read our news release to learn more about the insights they uncovered: https://lnkd.in/gAJnQAAY
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Every problem is unique, so every solution should be too. At 10x, we operate on first principles, so when we’re faced with a challenge, we don’t just ask, “How did we do it before?” We go deeper. We get to the root of the problem, and while we draw on our past knowledge and experiences, we always look for new and better ways to apply what we’ve learned. Watch our latest video to learn more about our company culture and see how we problem-solve. And if you’re finding that “We’ve always done it this way…” just isn’t cutting it, explore jobs here: https://bit.ly/3RJ2eV8 #WeAre10x
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Technology impacts the reliability of your #singlecell data. An independently conducted study reported that our Chromium Flex and 3' assays outperformed other technologies. See how the others stacked up: https://lnkd.in/ejWXYpAd
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Looks like the perfect box for hide and seq 👀
🎁 We got a nice little delivery today! 🎁 There’s been lots of interest in SEC-seq and what a better way to help our users get started than by leveraging our own Chromium instrument from 10x Genomics. Stay tuned for more paired secretion and transcriptome demonstrations! Also, did you know the box is great for playing hide-and-seek? 👀 #singlecell #technology #chromium #SECseq
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“To treat or not to treat” is a question that patients with precancerous #multiplemyeloma conditions and their physicians must tackle. Unfortunately, assessing risk of progression requires invasive methods with limited accuracy. A new project headed by the Foundation for the National Institutes of Health Biomarkers Consortium will use Chromium #singlecell assays to discover blood-based #biomarkers associated with #multiplemyeloma, offering hope for less invasive, more accurate risk assessment. Learn more: https://lnkd.in/gcg_kq35
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A recent Nature Neuroscience publication from the Brain Mind Institute in Switzerland uses Single Cell ATAC + Gene Expression to explore cell fate progression in organoid models.
A study by Fides Zenk et al. uses 10x Genomics single-cell sequencing to provide valuable insights into cell identity acquisition. The study focuses on the reconstruction of epigenomic trajectories in human neural organoid systems, shedding light on the intricate processes behind cell fate determination and diversity. By profiling histone modifications (H3K27ac, H3K27me3, and H3K4me3) and RNA expression in single cells, the researchers captured the transitions from pluripotency to differentiated neural fates. 🧪🧬 The results unveiled the temporal census of gene regulatory elements and transcription factors, providing valuable insights into cell identity acquisition. Notably, the study demonstrated that manipulating specific epigenetic modifications can disrupt fate restriction and lead to aberrant cell identity acquisition. This work utilized 10x Genomics products, such as scCUT&Tag and scRNA-seq, to enable high-resolution analysis at the single-cell level. The comprehensive single-cell epigenomic atlas of brain organoid development serves as a blueprint for further exploration of human cell fate determination. Read the full article here: https://lnkd.in/ghT78WNR Follow us for more insight into the use of 10x Genomics product in groundbreaking studies. Abiosciences has worked with many of our clients in similar studies by using our expertise in single-cell and spatial transcriptomics research to advance our understanding. Abiosciences scheduled a meeting with us: https://lnkd.in/gr7hbp-N
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From the beginning, our co-founders have been driven to make a long-lasting impact far beyond providing innovative research tools. They continually strive to make sure these tools will help researchers make meaningful discoveries that have the potential to truly change lives. As our co-founder and Chief Scientific Officer, Ben Hindson, often reminds us, it is this mission of “Accelerating the mastery of biology to advance human health” that pushes 10xers to take on the hardest challenges. Read more about our co-founders’ commitment to innovation and advancing human health: https://lnkd.in/gRBdmWRj #TogetherWeInnovate
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Want to get proof-of-concept data or run a trial with Xenium #InSitu? Find your catalyst & make the jump to #singlecellspatial with the Xenium Catalyst program! Learn more & contact a participating lab to get started: https://lnkd.in/gW5N4dwb
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Now shipping: Xenium Prime 5K pan tissue & pathways assays! eXplore your biology like never before with #singlecellspatial analysis of 5,000 genes featuring exceptional performance & industry-leading throughput. Request a quote here: https://lnkd.in/g7TsZu8M
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Very well-written blog post Joshua Azevedo ! Great work!