The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes (Q24316619)

identical protein binding

GOA release 2020-03-11

1 reference

Jannik Nedergaard Pedersen

GOA release 2020-03-11

1 reference

object named as

Jannik Nedergaard Pedersen

3

0 references

Daniel Otzen

object named as

Daniel Erik Otzen

5

0 references

author name string

Nikolai Lorenzen

1

0 references

Lasse Lemminger

2

0 references

Søren Bang Nielsen

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

4

0 references

language of work or name

English

0 references

publication date

31 January 2014

0 references

published in

FEBS Letters

0 references

volume

588

0 references

issue

3

0 references

page(s)

497-502

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Snaring the function of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

α-Synuclein in Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

α-Synuclein oligomers: an amyloid pore? Insights into mechanisms of α-synuclein oligomer-lipid interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Spin-label EPR on alpha-synuclein reveals differences in the membrane binding affinity of the two antiparallel helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Tryptophan fluorescence reveals structural features of alpha-synuclein oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Site-specific interaction between α-synuclein and membranes probed by NMR-observed methionine oxidation rates

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Structure and dynamics of micelle-bound human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Conformational properties of alpha-synuclein in its free and lipid-associated states

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

The first N-terminal amino acids of alpha-synuclein are essential for alpha-helical structure formation in vitro and membrane binding in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Locally resolved membrane binding affinity of the N-terminus of α-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Neurodegenerative disease: amyloid pores from pathogenic mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

In vivo demonstration that alpha-synuclein oligomers are toxic

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Structure-neurotoxicity relationships of amyloid beta-protein oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Membrane binding of oligomeric alpha-synuclein depends on bilayer charge and packing

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Assays for α-synuclein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

The influence of vesicle size and composition on alpha-synuclein structure and stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

ANS binding reveals common features of cytotoxic amyloid species

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Polymorphic fibrillation of the destabilized fourth fasciclin-1 domain mutant A546T of the Transforming growth factor-β-induced protein (TGFBIp) occurs through multiple pathways with different oligomeric intermediates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Role of elongation and secondary pathways in S6 amyloid fibril growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

The fold of alpha-synuclein fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Membrane Permeabilization by Oligomeric α-Synuclein: In Search of the Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

α-Synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Lipid bilayer disruption by oligomeric alpha-synuclein depends on bilayer charge and accessibility of the hydrophobic core.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

Asymmetric flow field-flow fractionation of liposomes: optimization of fractionation variables

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

7 January 2021

inferred from DOI database lookup

The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

7 January 2021

inferred from DOI database lookup

Membrane interaction of α-synuclein in different aggregation states

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.12.015

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1016/J.FEBSLET.2013.12.015

1 reference

Consolidated OpenCitations Corpus – April 2017

release_zorcxyotg5burjizbmlbhb72aq

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/zorcxyotg5burjizbmlbhb72aq

24 November 2022

mapped directly with Wikidata item

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

24374342

1 reference

Consolidated OpenCitations Corpus – April 2017