Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas (Q28213290)

1

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Lewis R Roberts

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Ileana N Aderca

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Xiangyang Dong

4

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Chiping Qian

5

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Linda M Murphy

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David M Nagorney

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Lawrence J Burgart

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Patrick C Roche

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David I Smith

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Julie A Ross

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Wanguo Liu

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

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language of work or name

English

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publication date

18 July 2002

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published in

Oncogene

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volume

21

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issue

31

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page(s)

4863-71

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cites work

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Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas

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Genomic structure, chromosome mapping and expression analysis of the human AXIN2 gene

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Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection

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Molecular basis of multistep hepatocarcinogenesis: genetic and epigenetic events

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Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis

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Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

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Activation of intracellular signaling by hepatitis B and C viruses: C-viral core is the most potent signal inducer.

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Beta-catenin accumulation and mutation of exon 3 of the beta-catenin gene in hepatocellular carcinoma.

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Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis

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Denaturing high performance liquid chromatography (DHPLC) used in the detection of germline and somatic mutations

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Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

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Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors

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Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24

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Beta-catenin as oncogene: the smoking gun.

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Hepatoblastoma in children: a review

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AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

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Hepatocellular carcinoma

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Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors

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The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

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Somatic mutations of β-catenin play a crucial role in the tumorigenesis of sporadic hepatoblastoma

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inferred from DOI database lookup

7 January 2021

based on heuristic

Expression of mutant nuclear beta-catenin correlates with non-invasive hepatocellular carcinoma, absence of portal vein spread, and good prognosis

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