Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes (Q28385506)

Diabetic cardiomyopathy-associated dysfunction in spatially distinct mitochondrial subpopulations

Europe PubMed Central

title

Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes (English)

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Subir K Roy Chowdhury

series ordinal

1

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Rick T Dobrowsky

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2

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Paul Fernyhough

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3

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language of work or name

English

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publication date

November 2011

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published in

Mitochondrion

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volume

11

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issue

6

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page(s)

845-54

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cites work

1 reference

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A combination of nutriments improves mitochondrial biogenesis and function in skeletal muscle of type 2 diabetic Goto-Kakizaki rats

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Alteration of renal respiratory Complex-III during experimental type-1 diabetes

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Aldose reductase, still a compelling target for diabetic neuropathy

20 March 2017

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Decreased complex II respiration and HNE-modified SDH subunit in diabetic heart

20 March 2017

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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

20 March 2017

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Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

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Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

7 April 2017

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7 April 2017

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AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

7 April 2017

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Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

7 April 2017

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7 April 2017

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Sensory neuropathy attributable to loss of Bcl-w

7 April 2017

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Diminished Superoxide Generation Is Associated With Respiratory Chain Dysfunction and Changes in the Mitochondrial Proteome of Sensory Neurons From Diabetic Rats

29 September 2017

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Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors

29 September 2017

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AMP-activated protein kinase and its downstream transcriptional pathways

29 September 2017

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Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.

29 September 2017

1 reference

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Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment

29 September 2017

1 reference

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Advanced glycation end products in extracellular matrix proteins contribute to the failure of sensory nerve regeneration in diabetes

29 September 2017

1 reference

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Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities

29 September 2017

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Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice.

29 September 2017

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A retrograde neuronal survival response: target-derived neurotrophins regulate MEF2D and bcl-w

29 September 2017

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PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

29 September 2017

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Development of selective axonopathy in adult sensory neurons isolated from diabetic rats: role of glucose-induced oxidative stress

29 September 2017

1 reference

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Insulin stimulates Akt translocation to mitochondria: implications on dysregulation of mitochondrial oxidative phosphorylation in diabetic myocardium

29 September 2017

1 reference

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Superoxide and respiratory coupling in mitochondria of insulin-deficient diabetic rats

29 September 2017

1 reference

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Diabetic polyneuropathy: an update

29 September 2017

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AMPK: a key regulator of energy balance in the single cell and the whole organism.

29 September 2017

1 reference

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Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.

29 September 2017

1 reference

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Treatment of Zucker diabetic fatty rats with AVE7688 improves vascular and neural dysfunction

29 September 2017

1 reference

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Type 2 diabetes with neuropathy: autoantibody stimulation of autophagy via Fas.

29 September 2017

1 reference

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Growth factors as therapeutics for diabetic neuropathy.

29 September 2017

1 reference

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Endoneurial microvascular pathology in feline diabetic neuropathy

29 September 2017

1 reference

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Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways

29 September 2017

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Transcriptional coregulators in the control of energy homeostasis

29 September 2017

1 reference

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Resveratrol stimulates AMP kinase activity in neurons

29 September 2017

1 reference

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Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle

29 September 2017

1 reference

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Early myocardial dysfunction in streptozotocin-induced diabetic mice: a study using in vivo magnetic resonance imaging (MRI).

29 September 2017

1 reference

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Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations

29 September 2017

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Glucose sensing by hypothalamic neurones and pancreatic islet cells: AMPle evidence for common mechanisms?

29 September 2017

1 reference

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Early diabetes-induced biochemical changes in the retina: comparison of rat and mouse models

29 September 2017

1 reference

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Sera from patients with type 2 diabetes and neuropathy induce autophagy and colocalization with mitochondria in SY5Y cells

29 September 2017

1 reference

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The role of AMP-activated protein kinase in mitochondrial biogenesis

29 September 2017

1 reference

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Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited

29 September 2017

1 reference

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Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications

29 September 2017

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Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy

29 September 2017

1 reference

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Oxidative stress in the pathogenesis of diabetic neuropathy

29 September 2017

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Effect of fidarestat and alpha-lipoic acid on diabetes-induced epineurial arteriole vascular dysfunction

29 September 2017

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Diabetic neuropathy in type 1 and type 2 diabetes and the effects of C-peptide

29 September 2017

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The Crabtree effect: a review

29 September 2017

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Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression

29 September 2017

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Protein kinase C changes in diabetes: is the concept relevant to neuropathy?

29 September 2017

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Glycation in diabetic neuropathy: characteristics, consequences, causes, and therapeutic options

29 September 2017

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Polyol pathway and diabetic peripheral neuropathy

29 September 2017

1 reference

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How does glucose generate oxidative stress in peripheral nerve?

29 September 2017

1 reference

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Neurofilaments in diabetic neuropathy

29 September 2017

1 reference

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Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy.

29 September 2017

1 reference

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Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.

29 September 2017

1 reference

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The missing link: a single unifying mechanism for diabetic complications.

29 September 2017

1 reference

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Pathogenetic mechanisms of diabetic neuropathy: lessons from animal models

29 September 2017

1 reference

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The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes

29 September 2017

1 reference

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Quantitation of epidermal nerves in diabetic neuropathy

29 September 2017

1 reference

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The effects of nerve growth factor and its antiserum on synapses in the superior cervical ganglion of the guinea-pig

29 September 2017

1 reference

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Early neural and vascular dysfunctions in diabetic rats are largely sequelae of increased sorbitol oxidation

29 September 2017

1 reference

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Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients

2 June 2018

1 reference

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Renal mitochondrial impairment is attenuated by AT1 blockade in experimental Type I diabetes

2 June 2018

1 reference

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The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy

2 June 2018

1 reference

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Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375692

Axonal cytoskeletal pathology in aged and diabetic human sympathetic autonomic ganglia

2 June 2018

1 reference

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Reduced skeletal muscle mitochondrial respiration and improved glucose metabolism in nondiabetic obese women during a very low calorie dietary intervention leading to rapid weight loss.

2 June 2018

1 reference

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Neuroprotective potential of combination of resveratrol and 4-amino 1,8 naphthalimide in experimental diabetic neuropathy: focus on functional, sensorimotor and biochemical changes.

27 November 2018

1 reference

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Improved glycaemic control decreases inner mitochondrial membrane leak in type 2 diabetes

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375692

Mitochondrial reactive oxygen species generation in obese non-diabetic and type 2 diabetic participants

27 November 2018

1 reference

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Effect of hyperglycemia on mitochondrial respiration in type 2 diabetes

27 November 2018

1 reference

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Gain-of-function R225Q mutation in AMP-activated protein kinase gamma3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle

27 November 2018

1 reference

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Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxidative capacity throughout the pathogenesis of type 2 diabetes

27 November 2018

1 reference

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High glucose downregulates endothelial progenitor cell number via SIRT1.

27 November 2018

1 reference

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Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity

27 November 2018

1 reference

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Neurotrophin-3 prevents mitochondrial dysfunction in sensory neurons of streptozotocin-diabetic rats

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375692

Experimental diabetic neuropathy with spontaneous recovery: is there irreparable damage?

27 November 2018

1 reference

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Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375692

Diabetes-induced abnormalities in ER calcium mobilization in primary and secondary nociceptive neurons.

27 November 2018

1 reference

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Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia.

27 November 2018

1 reference

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Preventing superoxide formation in epineurial arterioles of the sciatic nerve from diabetic rats restores endothelium-dependent vasodilation.

27 November 2018

1 reference

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Actin-ATP hydrolysis is a major energy drain for neurons.

27 November 2018

1 reference

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High glucose-induced oxidative stress and mitochondrial dysfunction in neurons.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375692

Neurological complications associated with spontaneously occurring feline diabetes mellitus

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375692

Diabetes-induced alterations in calcium homeostasis in sensory neurones of streptozotocin-diabetic rats are restricted to lumbar ganglia and are prevented by neurotrophin-3.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375692

An aldose reductase inhibitor reverses early diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375692

Dystrophic axonal swellings develop as a function of age and diabetes in human dorsal root ganglia.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375692

Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and Increases the Expression of Extracellular Matrix Genes in Human Skeletal Muscle

27 November 2018

1 reference

12 December 2020

Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals

1 reference

12 December 2020

Sural nerve pathology in diabetic patients with minimal but progressive neuropathy

1 reference

12 December 2020

Protective effect of N-acetylcysteine supplementation on mitochondrial oxidative stress and mitochondrial enzymes in cerebral cortex of streptozotocin-treated diabetic rats

1 reference

12 December 2020

Novel sites of aldose reductase immunolocalization in normal and streptozotocin-diabetic rats

1 reference

12 December 2020

Reduced perikaryal volume of lower motor and primary sensory neurons in early experimental diabetes

1 reference

12 December 2020

Voltage-dependent calcium currents are enhanced in dorsal root ganglion neurones from the Bio Bred/Worchester diabetic rat

1 reference

12 December 2020

Effects of resveratrol on nerve functions, oxidative stress and DNA fragmentation in experimental diabetic neuropathy

1 reference

12 December 2020

Mitochondrial Respiration Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes

1 reference

12 December 2020

Implication of insulin-like growth factors in the pathogenesis of diabetic neuropathy

1 reference

12 December 2020

Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-Jun NH2-terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage

1 reference

12 December 2020

Apoptotic stress is counterbalanced by survival elements preventing programmed cell death of dorsal root ganglions in subacute type 1 diabetic BB/Wor rats

1 reference

12 December 2020

Degeneration of the Golgi and neuronal loss in dorsal root ganglia in diabetic BioBreeding/Worcester rats

1 reference

12 December 2020

10.1016/J.MITO.2011.06.007

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

21742060

1 reference