NF-kappaB in cancer: from innocent bystander to major culprit (Q29614603)

Europe PubMed Central

title

NF-kappaB in cancer: from innocent bystander to major culprit (English)

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Karin M

1

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12001991

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Cao Y

series ordinal

2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12001991

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Greten FR

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3

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12001991

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Li ZW

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4

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12001991

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12001991

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language of work or name

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publication date

April 2002

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12001991

30 April 2017

published in

Nature Reviews Cancer

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volume

2

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issue

4

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page(s)

301-10

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12001991

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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cites work

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Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

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RelB cellular regulation and transcriptional activity are regulated by p100.

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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

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The Hallmarks of Cancer

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P53 plays a protective role against UV- and cisplatin-induced apoptosis in transcription-coupled repair proficient fibroblasts.

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The role of Rel/NF-kappa B proteins in viral oncogenesis and the regulation of viral transcription

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NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.

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NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition

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IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

31 March 2020

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An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

31 March 2020

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Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

31 March 2020

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Suppression of TNF-alpha-induced apoptosis by NF-kappaB

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TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

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NF-kappaB at the crossroads of life and death

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Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB

31 March 2020

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p53, the cellular gatekeeper for growth and division

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Transcriptional cross talk between NF-kappaB and p53.

31 March 2020

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Interleukin-8 as a macrophage-derived mediator of angiogenesis

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Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA

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Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-kappa B

31 March 2020

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Characterization of a novel promoter insertion in the c-rel locus

31 March 2020

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Malignant transformation of primary chicken spleen cells by human transcription factor c-Rel

31 March 2020

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Identification of a tumor-associated mutant form of the NF-kappaB RelA gene with reduced DNA-binding and transactivating activities

31 March 2020

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B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50

31 March 2020

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Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2.

31 March 2020

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The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control

31 March 2020

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The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators

31 March 2020

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Constitutive expression of Bc1-3 in thymocytes increases the DNA binding of NF-kappaB1 (p50) homodimers in vivo

31 March 2020

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Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice.

31 March 2020

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Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

31 March 2020

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The role of Epstein-Barr virus in neoplastic transformation

31 March 2020

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A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation

31 March 2020

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The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily

31 March 2020

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Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells

31 March 2020

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B-cell lymphoma of MALT type: a review with special emphasis on diagnostic and management problems of low-grade gastric tumours

31 March 2020

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Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types

31 March 2020

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Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure

31 March 2020

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A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue

31 March 2020

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Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway

31 March 2020

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Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.

31 March 2020

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Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells

31 March 2020

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NF-kappa B inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cells

31 March 2020

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Selective activation of NF-kappa B subunits in human breast cancer: potential roles for NF-kappa B2/p52 and for Bcl-3

31 March 2020

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Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer

31 March 2020

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Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth

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Activation of NF-kappaB/Rel occurs early during neoplastic transformation of mammary cells

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Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN.

31 March 2020

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HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway

31 March 2020

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Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation

31 March 2020

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Signaling pathways in mammary gland development.

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NF-kappaB inhibits apoptosis in murine mammary epithelia

31 March 2020

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The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

31 March 2020

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Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

31 March 2020

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Cyclin D1 provides a link between development and oncogenesis in the retina and breast

31 March 2020

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Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions

31 March 2020

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Specific protection against breast cancers by cyclin D1 ablation

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The nuclear factor kappa B (NF-kappa B): a potential therapeutic target for estrogen receptor negative breast cancers

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Helicobacter pylori and gastrointestinal tract adenocarcinomas

31 March 2020

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Interleukin-1 polymorphisms associated with increased risk of gastric cancer

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Helicobacter pylori infection activates NF-kappa B in gastric epithelial cells

31 March 2020

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Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases

31 March 2020

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Nuclear factor-kappa B is upregulated in colorectal cancer

31 March 2020

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NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps

31 March 2020

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Hereditary gastrointestinal polyposis and nonpolyposis syndromes.

31 March 2020

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The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis

31 March 2020

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Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice

31 March 2020

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Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa

31 March 2020

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Increased risk of large-bowel cancer in Crohn's disease with colonic involvement

31 March 2020

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Interleukin-10-deficient mice develop chronic enterocolitis

31 March 2020

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Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B

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Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta

31 March 2020

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Inhibition of interleukin-1-stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity

31 March 2020

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Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation

31 March 2020

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Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

31 March 2020

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Elevated cyclooxygenase-2 levels in Min mouse adenomas

31 March 2020

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31 March 2020

COX-2 and colon cancer

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Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

31 March 2020

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Aspirin use and the risk for colorectal cancer and adenoma in male health professionals

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Aspirin use and reduced risk of fatal colon cancer

31 March 2020

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Aspirin protects against gastric cancer: results of a case-control study from Moscow, Russia.

31 March 2020

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The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

31 March 2020

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Sulindac inhibits activation of the NF-kappaB pathway

31 March 2020

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Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex

31 March 2020

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Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7,12-dimethylbenz[a]anthracene-induced mammary cancer in rats.

31 March 2020

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Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway.

31 March 2020

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31 March 2020

Cancer statistics, 2000.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12001991

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Identifiers

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1354942

Dimensions Publication ID

1024581782

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OpenCitations bibliographic resource ID

1354942

1 reference