ADAM metallopeptidase with thrombospondin type 1 motif 12 (Q21105326)

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mammalian protein found in Homo sapiens

ADAMTS-12
ADAMTS12
ADAM-TS 12
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12
A disintegrin and metalloproteinase with thrombospondin motifs 12
ADAM-TS12

Language	Label	Description	Also known as
English	ADAM metallopeptidase with thrombospondin type 1 motif 12	mammalian protein found in Homo sapiens	ADAMTS-12 ADAMTS12 ADAM-TS 12 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 A disintegrin and metalloproteinase with thrombospondin motifs 12 ADAM-TS12

Statements

1 reference

13 November 2019

UniProt protein ID

Thrombospondin type-1 (TSP1) repeat superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P58397

Metallopeptidase, catalytic domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P58397

ADAMTS/ADAMTS-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P58397

Peptidase M12B, ADAM/reprolysin, protein family

1 reference

based on heuristic

inferred from protein domain or family

ADAM-TS Spacer 1, protein family

1 reference

based on heuristic

inferred from protein domain or family

PLAC, protein family

1 reference

based on heuristic

inferred from protein domain or family

Thrombospondin type-1 (TSP1) repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase M12B, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

protein binding

determination method or standard

5 references

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

8 April 2019

ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

8 April 2019

Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

8 April 2019

ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

8 April 2019

Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

metalloendopeptidase activity

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

8 April 2019

The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

8 April 2019

ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

8 April 2019

Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

hydrolase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

extracellular region

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

extracellular matrix

determination method or standard

1 reference

24 April 2018

Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58397&geneProductId=UniProtKB:P58397

determination method or standard

collagen-containing extracellular matrix

determination method or standard

1 reference

1 January 2018

Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

biological process

regulation of endothelial tube morphogenesis

determination method or standard

1 reference

8 April 2019

The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

proteoglycan catabolic process

determination method or standard

1 reference

8 April 2019

The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

negative regulation of hepatocyte growth factor receptor signaling pathway

determination method or standard

1 reference

8 April 2019

The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

negative regulation of cellular response to vascular endothelial growth factor stimulus

determination method or standard

1 reference

8 April 2019

The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

cellular response to tumor necrosis factor

determination method or standard

1 reference

8 April 2019

Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

cellular response to BMP stimulus

determination method or standard

1 reference

8 April 2019

Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

negative regulation of cellular response to hepatocyte growth factor stimulus

determination method or standard

1 reference

8 April 2019

The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

negative regulation of chondrocyte differentiation

determination method or standard

1 reference

8 April 2019

Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

cellular response to interleukin-1

determination method or standard

1 reference

8 April 2019

Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

regulation of inflammatory response

determination method or standard

1 reference

8 April 2019

ADAMTS-12 metalloprotease is necessary for normal inflammatory response

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

proteolysis involved in cellular protein catabolic process

determination method or standard

cell-matrix adhesion

determination method or standard

1 reference

8 April 2019

Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion?

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

determination method or standard

1 reference

8 April 2019

Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion?

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

determination method or standard

Thrombospondin type-1 (TSP1) repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P58397

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P58397

Peptidase M12B, ADAM/reprolysin

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P58397

ADAM-TS Spacer 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P58397

Peptidase M12B, propeptide

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P58397

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000344847

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000344847

ENSP00000422554

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422554

ENSP00000421638

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421638

ENSP00000486213

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486213

ENSP00000486915

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486915

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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