Protein kinases as drug targets in trypanosomes and Leishmania (Q34578463)

3 August 2017

1 reference

title

Protein kinases as drug targets in trypanosomes and Leishmania (English)

1 reference

3 August 2017

Marilyn Parsons

2

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Jeremy C. Mottram

object named as

Jeremy C Mottram

series ordinal

3

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author name string

Christina Naula

series ordinal

1

1 reference

3 August 2017

language of work or name

English

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publication date

8 September 2005

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Biochimica et Biophysica Acta

3 August 2017

published in

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3 August 2017

volume

1754

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3 August 2017

issue

1-2

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3 August 2017

page(s)

151-159

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Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi

3 August 2017

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1 reference

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7 July 2018

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The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease

7 July 2018

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Pairwise knockdowns of cdc2-related kinases (CRKs) in Trypanosoma brucei identified the CRKs for G1/S and G2/M transitions and demonstrated distinctive cytokinetic regulations between two developmental stages of the organism

7 July 2018

1 reference

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Trypanosoma brucei MOB1 is required for accurate and efficient cytokinesis but not for exit from mitosis

7 July 2018

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LmxMPK9, a mitogen-activated protein kinase homologue affects flagellar length in Leishmania mexicana.

7 July 2018

1 reference

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Trypanosoma cruzi histone H1 is phosphorylated in a typical cyclin dependent kinase site accordingly to the cell cycle.

7 July 2018

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Roles of NF-kappaB and bcl-2 in two differential modes of cell death of mouse cortical collecting duct cells

7 July 2018

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Targeting the mitogen-activated protein kinase cascade to treat cancer

7 July 2018

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Leishmaniasis: drugs in the clinic, resistance and new developments.

7 July 2018

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A plethora of targets, a paucity of drugs: progress towards the development of novel chemotherapies for human African trypanosomiasis

7 July 2018

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Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote

7 July 2018

1 reference

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Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity

7 July 2018

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Overriding imatinib resistance with a novel ABL kinase inhibitor

7 July 2018

1 reference

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Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol

7 July 2018

1 reference

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Kinomics-structural biology and chemogenomics of kinase inhibitors and targets

7 July 2018

1 reference

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Identification of mitogen-activated protein kinase homologues from Leishmania mexicana.

7 July 2018

1 reference

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The cell cycle of parasitic protozoa: potential for chemotherapeutic exploitation.

7 July 2018

1 reference

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Leishmaniasis--current chemotherapy and recent advances in the search for novel drugs

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Specific chemotherapy of Chagas disease: controversies and advances

7 July 2018

1 reference

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Protein kinase involved in flagellar-length control.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Stage-specific differences in cell cycle control in Trypanosoma brucei revealed by RNA interference of a mitotic cyclin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

The protein kinase complement of the human genome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Stage-specific requirement of a mitogen-activated protein kinase by Trypanosoma brucei

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

7 July 2018

1 reference

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Cloning of a cdc2-related protein kinase from Trypanosoma cruzi that interacts with mammalian cyclins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

A mitogen-activated protein (MAP) kinase homologue of Leishmania mexicana is essential for parasite survival in the infected host.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Gene disruptions indicate an essential function for the LmmCRK1 cdc2-related kinase of Leishmania mexicana

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Leishmania mexicana p12cks1, a homologue of fission yeast p13suc1, associates with a stage-regulated histone H1 kinase.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Differential accumulation of a protein kinase homolog in Trypanosoma brucei

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

A novel ERK-like, CRK-like protein kinase that modulates growth in Trypanosoma brucei via an autoregulatory C-terminal extension.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Inactive enzyme-homologues find new function in regulatory processes

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

The Trypanosoma brucei cyclin, CYC2, is required for cell cycle progression through G1 phase and for maintenance of procyclic form cell morphology

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

The involvement of two cdc2-related kinases (CRKs) in Trypanosoma brucei cell cycle regulation and the distinctive stage-specific phenotypes caused by CRK3 depletion

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

A PHO80-like cyclin and a B-type cyclin control the cell cycle of the procyclic form of Trypanosoma brucei.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Evidence for CRK3 participation in the cell division cycle of Trypanosoma cruzi

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Homologues of LMPK, a mitogen-activated protein kinase from Leishmania mexicana, in different Leishmania species.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Characterization of the Trypanosoma cruzi Cdc2p-related protein kinase 1 and identification of three novel associating cyclins

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Trypanosoma brucei CYC1 does not have characteristics of a mitotic cyclin

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Isolation of Trypanosoma brucei CYC2 and CYC3 cyclin genes by rescue of a yeast G(1) cyclin mutant. Functional characterization of CYC2.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Stage-specific activity of the Leishmania major CRK3 kinase and functional rescue of a Schizosaccharomyces pombe cdc2 mutant

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

The crk3 gene of Leishmania mexicana encodes a stage-regulated cdc2-related histone H1 kinase that associates with p12.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Interferon-gamma activation of a mitogen-activated protein kinase, KFR1, in the bloodstream form of Trypanosoma brucei

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

A Trypanosoma brucei gene family encoding protein kinases with catalytic domains structurally related to Nek1 and NIMA.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Isolation of a mitotic-like cyclin homologue from the protozoan Trypanosoma brucei

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Translational control mediates the developmental regulation of the Trypanosoma brucei Nrk protein kinase.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1452262

Cell cycle-specific induction of an 89 kDa serine/threonine protein kinase activity in Trypanosoma brucei

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16198642

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Raf kinase inhibitors in oncology

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16198642

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BBAPAP.2005.08.018

1 reference

3 August 2017

1 reference

3 August 2017

1 reference