The "Gab" in signal transduction. (Q35082143)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12628344%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

review article

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title

The "Gab" in signal transduction (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12628344%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12628344%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

author name string

Haihua Gu

series ordinal

1

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1 November 2019

publication date

1 March 2003

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1 November 2019

published in

Trends in Cell Biology

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1 November 2019

volume

13

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1 November 2019

issue

3

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1 November 2019

page(s)

122-130

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Cell signaling by receptor tyrosine kinases

1 November 2019

cites work

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

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Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

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7 January 2021

Gab3, a new DOS/Gab family member, facilitates macrophage differentiation

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7 January 2021

Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling

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7 January 2021

DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.

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7 January 2021

The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction

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7 January 2021

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

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Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

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7 January 2021

Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis

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7 January 2021

Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

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7 January 2021

Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356.

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7 January 2021

Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.

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7 January 2021

Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation

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7 January 2021

SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases

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7 January 2021

Signaling via Shc family adapter proteins

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7 January 2021

New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

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7 January 2021

Shc associates with the IL-3 receptor β subunit, SHIP and Gab2 following IL-3 stimulation

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7 January 2021

Role of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo)

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7 January 2021

Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase.

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7 January 2021

Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

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7 January 2021

Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways

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7 January 2021

A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains

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7 January 2021

Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

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7 January 2021

A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

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7 January 2021

A conserved inositol phospholipid binding site within the pleckstrin homology domain of the Gab1 docking protein is required for epithelial morphogenesis

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7 January 2021

The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase.

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7 January 2021

In vivo functional analysis of the daughter of sevenless protein in receptor tyrosine kinase signaling

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7 January 2021

The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase

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7 January 2021

Cutting edge: gab2 mediates an inhibitory phosphatidylinositol 3'-kinase pathway in T cell antigen receptor signaling

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7 January 2021

Signal characteristics of G protein-transactivated EGF receptor

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7 January 2021

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

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7 January 2021

Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules

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7 January 2021

The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression

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7 January 2021

Activated ERK2 interacts with and phosphorylates the docking protein GAB1.

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7 January 2021

ERK regulates the hepatocyte growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase

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7 January 2021

ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase

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7 January 2021

Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength

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7 January 2021

Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases

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7 January 2021

PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.

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7 January 2021

The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase

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7 January 2021

Requirement of SHP2 binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor

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7 January 2021

Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

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7 January 2021

Essential role of Gab1 for signaling by the c-Met receptor in vivo

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7 January 2021

A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.

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7 January 2021

Regulation of the mitogen-activated protein kinase signaling pathway by SHP2.

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7 January 2021

Shp-2 tyrosine phosphatase: signaling one cell or many

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7 January 2021

Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.

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7 January 2021

Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase

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7 January 2021

Requirement of Gab2 for mast cell development and KitL/c-Kit signaling

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7 January 2021

Recruitment of the protein tyrosine phosphatase CSW by DOS is an essential step during signaling by the sevenless receptor tyrosine kinase

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https://api.crossref.org/works/10.1016%2FS0962-8924%2803%2900002-3

7 January 2021

Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2

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7 January 2021

Characterization of two SHP-2-associated binding proteins and potential substrates in hematopoietic cells.

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7 January 2021

Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

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7 January 2021

Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes

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7 January 2021

Essential role for Gab2 in the allergic response

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7 January 2021

Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2803%2900002-3

7 January 2021

A yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partners

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7 January 2021

Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL

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7 January 2021

Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis

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7 January 2021

Adapter molecule Grb2-associated binder 1 is specifically expressed in marginal zone B cells and negatively regulates thymus-independent antigen-2 responses

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7 January 2021

Critical role for Gab2 in transformation by BCR/ABL

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7 January 2021

Pathogenesis and treatment of Ph+ leukemia: recent insights from mouse models

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7 January 2021

ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation

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7 January 2021

Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.

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7 January 2021

Concomitant activation of the PI3K-Akt and the Ras-ERK signaling pathways is essential for transformation by the V-SEA tyrosine kinase oncogene

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7 January 2021

Erythroid cells rendered erythropoietin independent by infection with Friend spleen focus-forming virus show constitutive activation of phosphatidylinositol 3-kinase and Akt kinase: involvement of insulin receptor substrate-related adapter proteins.

1 reference

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7 January 2021

Comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and rat

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7 January 2021

The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer

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7 January 2021

Expression of Gab1 lacking the pleckstrin homology domain is associated with neoplastic progression

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7 January 2021

10.1016/S0962-8924(03)00002-3

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12628344%20AND%20SRC:MED&resulttype=core&format=json

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1 November 2019

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24 November 2022

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