Enhancing the biocatalytic manufacture of the key intermediate of atorvastatin by focused directed evolution of halohydrin dehalogenase (Q36271261)

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1 April 2020

title

Enhancing the biocatalytic manufacture of the key intermediate of atorvastatin by focused directed evolution of halohydrin dehalogenase (English)

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1 April 2020

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3

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1 April 2020

author name string

Yu Luo

1

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1 April 2020

Yangzi Chen

2

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1 April 2020

ZhenHua Tian

4

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1 April 2020

Yeqi Zhang

5

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1 April 2020

Jian Zhang

6

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1 April 2020

language of work or name

English

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publication date

6 February 2017

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1 April 2020

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1 April 2020

volume

7

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1 April 2020

page(s)

42064

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Creative Commons Attribution 4.0 International

1 April 2020

copyright license

start time

1 February 2017

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Recent advances on halohydrin dehalogenases-from enzyme identification to novel biocatalytic applications

1 reference

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Biocatalysis: A Status Report

30 September 2017

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A single point mutation enhances hydroxynitrile synthesis by halohydrin dehalogenase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5292711

Expanding the Halohydrin Dehalogenase Enzyme Family: Identification of Novel Enzymes by Database Mining

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5292711

Biocatalysis in organic chemistry and biotechnology: past, present, and future

30 September 2017

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A highly productive, whole-cell DERA chemoenzymatic process for production of key lactonized side-chain intermediates in statin synthesis

30 September 2017

1 reference

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Properties and biotechnological applications of halohydrin dehalogenases: current state and future perspectives

30 September 2017

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Engineering the third wave of biocatalysis

30 September 2017

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Key residues for controlling enantioselectivity of Halohydrin dehalogenase from Arthrobacter sp. strain AD2, revealed by structure-guided directed evolution

30 September 2017

1 reference

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Laboratory evolution of stereoselective enzymes: a prolific source of catalysts for asymmetric reactions

30 September 2017

1 reference

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A high-throughput colorimetric assay for screening halohydrin dehalogenase saturation mutagenesis libraries

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5292711

Engineered enzymes for chemical production

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5292711

Structure and mechanism of a bacterial haloalcohol dehalogenase: a new variation of the short-chain dehydrogenase/reductase fold without an NAD(P)H binding site

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5292711

Biocatalytic conversion of epoxides

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5292711

Halohydrin dehalogenases are structurally and mechanistically related to short-chain dehydrogenases/reductases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5292711

Engineered, highly productive biosynthesis of artificial, lactonized statin side-chain building blocks: The hidden potential of Escherichia coli unleashed.

30 September 2017

1 reference

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Resolution of 2,2-disubstituted epoxides via biocatalytic azidolysis

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5292711

Improving catalytic function by ProSAR-driven enzyme evolution

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5292711

Improved catalytic properties of halohydrin dehalogenase by modification of the halide-binding site

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5292711

Steady-state kinetics and tryptophan fluorescence properties of halohydrin dehalogenase from Agrobacterium radiobacter. Roles of W139 and W249 in the active site and halide-induced conformational change

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5292711

Cloning of two halohydrin hydrogen-halide-lyase genes of Corynebacterium sp. strain N-1074 and structural comparison of the genes and gene products

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5292711

Creating randomized amino acid libraries with the QuikChange Multi Site-Directed Mutagenesis Kit

22 September 2018

1 reference

12 December 2020

Highly enantioselective and regioselective biocatalytic azidolysis of aromatic epoxides

1 reference

12 December 2020

Formation of enantiopure 5-substituted oxazolidinones through enzyme-catalysed kinetic resolution of epoxides

1 reference

12 December 2020

Biochemical and biocatalytic characterization of 17 novel halohydrin dehalogenases

1 reference

12 December 2020

Asymmetric synthesis of optically active methyl-2-benzamido-methyl-3-hydroxy-butyrate by robust short-chain alcohol dehydrogenases from Burkholderia gladioli

1 reference

12 December 2020

Identifiers

DOI

10.1038/SREP42064

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28165015%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28165015%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

PubMed publication ID

28165015

1 reference