Pax5: the guardian of B cell identity and function (Q36794303)

16 August 2017

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title

Pax5: the guardian of B cell identity and function (English)

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16 August 2017

1

Cobaleda C

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16 August 2017

3

Delogu A

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16 August 2017

4

Busslinger M

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16 August 2017

Alexandra Schebesta

2

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16 August 2017

language of work or name

English

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publication date

1 May 2007

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16 August 2017

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16 August 2017

volume

8

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issue

5

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16 August 2017

page(s)

463-470

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Transcriptional control of early B cell development

16 August 2017

cites work

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7 January 2021

B lymphocyte-specific protein binding near an immunoglobulin kappa-chain gene J segment

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7 January 2021

A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation

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7 January 2021

A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation

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7 January 2021

Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis

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7 January 2021

Pax-5 is identical to EBB-1/KLP and binds to the VpreB and lambda5 promoters as well as the KI and KII sites upstream of the Jkappa genes

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7 January 2021

DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.

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7 January 2021

Structural studies of Ets-1/Pax5 complex formation on DNA

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7 January 2021

Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter

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7 January 2021

Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments

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7 January 2021

C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8.

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7 January 2021

The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells

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7 January 2021

A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription

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Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family

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7 January 2021

Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.

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7 January 2021

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

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7 January 2021

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

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7 January 2021

Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

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7 January 2021

Multiple hematopoietic cell lineages develop in vivo from transplanted Pax5-deficient pre-B I-cell clones

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7 January 2021

Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors.

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7 January 2021

Extensive in vivo self-renewal, long-term reconstitution capacity, and hematopoietic multipotency of Pax5-deficient precursor B-cell clones

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7 January 2021

Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors

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7 January 2021

Independent regulation of the two Pax5 alleles during B-cell development.

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7 January 2021

Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function

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7 January 2021

A B220+ CD117+ CD19- hematopoietic progenitor with potent lymphoid and myeloid developmental potential

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7 January 2021

Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila

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7 January 2021

twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development

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7 January 2021

Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1.

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7 January 2021

Pax5 determines B- versus T-cell fate and does not block early myeloid-lineage development

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Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes

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7 January 2021

Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A.

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7 January 2021

Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A

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EBF-regulating Pax5 transcription is enhanced by STAT5 in the early stage of B cells

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Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene

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Loss of Pax5 promotes plasma cell differentiation

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Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5

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Multilineage gene expression precedes commitment in the hemopoietic system

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Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells

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Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment

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Cellular niches controlling B lymphocyte behavior within bone marrow during development.

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The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction

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The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP

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Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis

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Control of pre-BCR signaling by Pax5-dependent activation of the BLNK gene

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Distinct signaling requirements for Dmu selection, IgH allelic exclusion, pre-B cell transition, and tumor suppression in B cell progenitors

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Reversion of B cell commitment upon loss of Pax5 expression

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The mechanism and regulation of chromosomal V(D)J recombination

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Complete sequence assembly and characterization of the C57BL/6 mouse Ig heavy chain V region

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Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments

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Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development

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Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene

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Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells

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Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.

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B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5

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Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4

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Transcription factor Pax5 (BSAP) transactivates the RAG-mediated V(H)-to-DJ(H) rearrangement of immunoglobulin genes

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Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program

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Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells

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7 January 2021

BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

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Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1

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7 January 2021

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

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7 January 2021

Stepwise reprogramming of B cells into macrophages

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Antagonistic effect of CCAAT enhancer-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors

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Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

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Deregulation of PAX-5 by translocation of the Emu enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma

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7 January 2021

PAX5/IGH rearrangement is a recurrent finding in a subset of aggressive B-NHL with complex chromosomal rearrangements

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7 January 2021

Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus.

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Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

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7 January 2021

PAX5/ETV6 fusion defines cytogenetic entity dic(9;12)(p13;p13).

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7 January 2021

A novel PAX5-ELN fusion protein identified in B-cell acute lymphoblastic leukemia acts as a dominant negative on wild-type PAX5.

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

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7 January 2021

Identifiers

DOI

10.1038/NI1454

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16 August 2017

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