The cell biology of the insulin receptor (Q38696431)

5 September 2017

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title

The cell biology of the insulin receptor (English)

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5 September 2017

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J L Carpentier

1

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5 September 2017

publication date

1 September 1989

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5 September 2017

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5 September 2017

volume

32

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5 September 2017

issue

9

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5 September 2017

page(s)

627-635

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Membrane recycling by coated vesicles

5 September 2017

cites work

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12 December 2020

Lysosomal association of internalized 125I-insulin in isolated rat hepatocytes. Direct demonstration by quantitative electron microscopic autoradiography

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12 December 2020

Tyrosine-specific protein kinase activity is associated with the purified insulin receptor

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12 December 2020

Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts

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12 December 2020

Receptor-mediated endocytosis of insulin: role of microvilli, coated pits, and coated vesicles

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12 December 2020

Biochemical and morphological evidence that the insulin receptor is internalized with insulin in hepatocytes

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12 December 2020

Detection of surface-bound ligands by freeze-fracture autoradiography

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12 December 2020

Internalized insulin receptors are recycled to the cell surface in rat hepatocytes

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12 December 2020

Internalization of insulin receptors in the isolated rat adipose cell. Demonstration of the vectorial disposition of receptor subunits

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12 December 2020

Intracellular Translocation of Iodine-125-Labeled Insulin: Direct Demonstration in Isolated Hepatocytes

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12 December 2020

Receptors for Insulin, NSILA-s, and Growth Hormone: Applications to Disease States in Man

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12 December 2020

Down-regulation and recycling of insulin receptors. Effect of monensin on IM-9 lymphocytes and U-937 monocyte-like cells

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12 December 2020

Inhibitors of 125I-epidermal growth factor internalization

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12 December 2020

Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: studies in 2,4-dinitrophenol-treated cells

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12 December 2020

Insulin-like growth factor I rapidly stimulates tyrosine phosphorylation of a Mr 185,000 protein in intact cells

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12 December 2020

Insulin receptor is an insulin-dependent tyrosine protein kinase: copurification of insulin-binding activity and protein kinase activity to homogeneity from human placenta

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12 December 2020

Rapid acidification of endocytic vesicles containing alpha 2-macroglobulin

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12 December 2020

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

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12 December 2020

Binding, membrane redistribution, internalization and lysosomal association of [125I]anti-insulin receptor antibody in IM-9-cultured human lymphocyte. A comparison with [125I]insulin

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12 December 2020

An electron microscope autoradiographic study of the carbohydrate recognition systems in rat liver. I. Distribution of 125I-ligands among the liver cell types

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12 December 2020

Redistribution of 125I-insulin on the surface of rat hepatocytes as a function of dissociation time

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12 December 2020

Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity

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12 December 2020

Rapid endocytosis of the transferrin receptor in the absence of bound transferrin

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12 December 2020

Insulin degradation by hepatocytes in primary culture

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12 December 2020

Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro

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12 December 2020

Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation

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12 December 2020

Defective internalization of insulin and its receptor in cells expressing mutated insulin receptors lacking kinase activity

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12 December 2020

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin

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12 December 2020

On the Physiology of the Salivary Secretion: Part II. On the Mutual Antagonism of Atropin and Pilocarpin, having especial reference to their relations in the Sub-maxillary Gland of the Cat

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12 December 2020

Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase

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12 December 2020

Receptor-mediated endocytosis of insulin: inhibition of [125I]iodoinsulin internalization in insulin resistant diabetic states of man.

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12 December 2020

Direct demonstration of insulin receptor internalization. A quantitative electron microscopic study of covalently bound 125I-photoreactive insulin incubated with isolated hepatocytes

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12 December 2020

Insulin-Receptor Interactions in Adipose Tissue Cells: Direct Measurement and Properties

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12 December 2020

Binding, internalization, and lysosomal association of 125I-human growth hormone in cultured human lymphocytes: a quantitative morphological and biochemical study

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12 December 2020

Phosphorylation activates the insulin receptor tyrosine protein kinase

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12 December 2020

125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography

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12 December 2020

Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase

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12 December 2020

The mannose-6-phosphate receptor for lysosomal enzymes is concentrated in cis Golgi cisternae

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12 December 2020

Symposium III: Hormones and hormone receptors. A morphological approach to surface receptors in islet and liver cells

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12 December 2020

Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts

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12 December 2020

Autophosphorylation of the insulin receptor in vitro. Designation of phosphorylation sites and correlation with receptor kinase activation

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12 December 2020

alpha 2 Macroglobulin binding to the plasma membrane of cultured fibroblasts. Diffuse binding followed by clustering in coated regions

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12 December 2020

Transglutaminase is essential in receptor-mediated endocytosis of α2-macroglobulin and polypeptide hormones

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12 December 2020

Rapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor

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12 December 2020

Binding, internalization, and lysosomal association of 125I-glucagon in isolated rat hepatocytes. A quantitative electron microscope autoradiographic study

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12 December 2020

Role of intracellular calcium and protein kinase C in the endocytosis of transferrin and insulin by HL60 cells

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12 December 2020

Receptor-linked degradation of 125I-insulin is mediated by internalization in isolated rat hepatocytes

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12 December 2020

Intracellular localization of 125I-labeled insulin in hepatocytes from intact rat liver

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12 December 2020

Monensin blocks the maturation of receptors for insulin and somatomedin C: Identification of receptor precursors

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12 December 2020

Insulin receptors in the liver: specific binding of ( 125 I)insulin to the plasma membrane and its relation to insulin bioactivity

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12 December 2020

Stimulation of tyrosine-specific phosphorylation in vitro by insulin-like growth factor I

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12 December 2020

Down-regulation of insulin receptors is related to insulin internalization

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12 December 2020

Insulin rapidly stimulates phosphorylation of a 46-kDa membrane protein on tyrosine residues as well as phosphorylation of several soluble proteins in intact fat cells

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12 December 2020

Surface redistribution of 125I-insulin in cultured human lymphocytes

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12 December 2020

Platelet-derived growth factor stimulates tyrosine-specific protein kinase activity in Swiss mouse 3T3 cell membranes

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12 December 2020

Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts

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12 December 2020

Occurrence of low density lipoprotein receptors within large pits on the surface of human fibroblasts as demonstrated by freeze-etching

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12 December 2020

Evidence for recycling of insulin receptors in isolated rat adipocytes.

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12 December 2020

The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1

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12 December 2020

Receptor-mediated endocytosis of transferrin by developing erythroid cells from the fetal rat liver

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12 December 2020

Relationship of insulin binding and insulin-stimulated tyrosine kinase activity is altered in type II diabetes

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12 December 2020

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

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12 December 2020

Intracellular pathway followed by the insulin receptor covalently coupled to 125I-photoreactive insulin during internalization and recycling

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12 December 2020

Insulin Receptors, Receptor Antibodies, and the Mechanism of Insulin Action

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12 December 2020

Polypeptide hormone receptor phosphorylation: is there a role in receptor-mediated endocytosis of human growth hormone?

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12 December 2020

Direct visualization of the phosphorylated epidermal growth factor receptor during its internalization in A-431 cells

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12 December 2020

An endogenous substrate for the insulin receptor-associated tyrosine kinase

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12 December 2020

Evidence for the platelet-derived growth factor-stimulated tyrosine phosphorylation of the platelet-derived growth factor receptor in vivo. Immunopurification using a monoclonal antibody to phosphotyrosine

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12 December 2020

Receptor-mediated endocytosis of polypeptide hormones is a regulated process: inhibition of [125I]iodoinsulin internalization in hypoinsulinemic diabetes of rat and man

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12 December 2020

PMA induces the ligand-independent internalization of CR1 on human neutrophils

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12 December 2020

Tyrosine phosphorylation of the insulin receptor during insulin-stimulated internalization in rat hepatoma cells.

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12 December 2020

The glucose transporter in 3T3-L1 adipocytes is phosphorylated in response to phorbol ester but not in response to insulin

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12 December 2020

Rapid internalization of the transferrin receptor in K562 cells is triggered by ligand binding or treatment with a phorbol ester

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12 December 2020

Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor

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12 December 2020

The interaction of 125I-insulin with cultured 3T3-L1 adipocytes: quantitative analysis by the hypothetical grain method

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12 December 2020

Internalization of polypeptide hormones and receptor recycling

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12 December 2020

Identifiers

DOI

10.1007/BF00274248

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Dimensions Publication ID

5 September 2017

1009457559

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