Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors (Q33531734)

27 July 2017

title

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors (English)

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27 July 2017

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19

Kimberly Stegmaier

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27 July 2017

Wendy R Gordon

15

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author name string

Miguel Aste-Amézaga

1

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27 July 2017

Ningyan Zhang

2

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27 July 2017

Janet E Lineberger

3

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27 July 2017

Beth A Arnold

4

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27 July 2017

Timothy J Toner

5

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27 July 2017

Mingcheng Gu

6

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27 July 2017

Lingyi Huang

7

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27 July 2017

Salvatore Vitelli

8

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27 July 2017

Kim T Vo

9

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27 July 2017

Peter Haytko

10

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27 July 2017

Jing Zhang Zhao

11

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27 July 2017

Frederic Baleydier

12

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Sarah L'Heureux

13

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27 July 2017

Hongfang Wang

14

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27 July 2017

Elizabeth Thoryk

16

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Marie Blanke Andrawes

17

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27 July 2017

Kittichoat Tiyanont

18

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Giovanni Roti

20

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27 July 2017

Kenneth N Ross

21

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27 July 2017

Laura L Franlin

22

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27 July 2017

Hui Wang

23

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27 July 2017

Fubao Wang

24

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27 July 2017

Michael Chastain

25

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27 July 2017

Andrew J Bett

26

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Laurent P Audoly

27

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Jon C Aster

28

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Stephen C Blacklow

29

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27 July 2017

Hans E Huber

30

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27 July 2017

language of work or name

English

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publication date

8 February 2010

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27 July 2017

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27 July 2017

volume

5

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27 July 2017

issue

2

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27 July 2017

page(s)

e9094

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Creative Commons Attribution 4.0 International

27 July 2017

copyright license

start time

8 February 2010

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2

1 reference

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Targeting Notch signaling cross-talk with estrogen receptor and ErbB-2 in breast cancer

21 June 2018

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Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.

21 June 2018

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Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer

21 June 2018

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Nuclear signalling by tumour-associated antigen EpCAM

21 June 2018

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Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

21 June 2018

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Notch signaling regulates tumor angiogenesis by diverse mechanisms

21 June 2018

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The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia

21 June 2018

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NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL.

21 June 2018

1 reference

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Notch-1 regulates transcription of the epidermal growth factor receptor through p53.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Notch signaling in leukemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Notch signaling in normal and disease States: possible therapies related to glycosylation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

High-level JAG1 mRNA and protein predict poor outcome in breast cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Notch signaling in development and cancer.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Structural basis for autoinhibition of Notch

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

A method for high-throughput gene expression signature analysis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

NOTCH signaling as a novel cancer therapeutic target

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

JAGGED1 expression is associated with prostate cancer metastasis and recurrence

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Expression of notch receptors and ligands in the adult gut.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

A common enzyme connects notch signaling and Alzheimer's disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Fringe is a glycosyltransferase that modifies Notch

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Dll4, a novel Notch ligand expressed in arterial endothelium

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Delta-1 activation of notch-1 signaling results in HES-1 transactivation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

The Notch1 receptor is cleaved constitutively by a furin-like convertase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Jagged2: a serrate-like gene expressed during rat embryogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Jagged: A mammalian ligand that activates notch1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Signalling downstream of activated mammalian Notch

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Regulation of enzyme levels by proteolysis: the role of pest regions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Mastermind is a putative activator for Notch.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2817004

[Effect of CRE-dependent RNA interference targeting Notch1 on proliferation of cervical cancer cell line HeLa]

31 October 2018

1 reference

12 December 2020

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

12 December 2020

Chromosome 19 translocation, overexpression of Notch3, and human lung cancer

1 reference

12 December 2020

Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0009094

Identifiers

DOI

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27 July 2017

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27 July 2017

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