Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo (Q33810588)

29 July 2017

title

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo (English)

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29 July 2017

10

An Zwijsen

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Marcel W Coolen

object named as

Marcel Coolen

8

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Sébastien S. Hébert

object named as

Sébastien Hébert

7

0 references

Bart De Strooper

13

object named as

Bart De Strooper

1 reference

29 July 2017

Lutgarde Serneels

1

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ORCID Public Data File 2021

author name string

Tim Dejaegere

2

1 reference

29 July 2017

Katleen Craessaerts

3

1 reference

29 July 2017

Katrien Horré

4

1 reference

29 July 2017

Ellen Jorissen

5

1 reference

29 July 2017

Thomas Tousseyn

6

1 reference

29 July 2017

Gerard Martens

9

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29 July 2017

Wim Annaert

11

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29 July 2017

Dieter Hartmann

12

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29 July 2017

language of work or name

English

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publication date

21 January 2005

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Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

published in

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29 July 2017

volume

102

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29 July 2017

issue

5

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29 July 2017

page(s)

1719-1724

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Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

29 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

Segmentation in vertebrates: clock and gradient finally joined

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

Identification of distinct gamma-secretase complexes with different APH-1 variants

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

The role of presenilin cofactors in the gamma-secretase complex

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

A cell biological perspective on Alzheimer's disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

Mice lacking both presenilin genes exhibit early embryonic patterning defects

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

Gamma-secretase: proteasome of the membrane?

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

Reconstitution of gamma-secretase activity

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547495

The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15665098

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Gene dosage effect on gamma-secretase component Aph-1b in a rat model for neurodevelopmental disorders

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15665098

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0408901102

1 reference

29 July 2017

0 references

1 reference

29 July 2017

1 reference