Progress of cancer research on astrocyte elevated gene-1/Metadherin (Review). (Q33844259)

29 July 2017

title

Progress of cancer research on astrocyte elevated gene-1/Metadherin (Review). (English)

1 reference

29 July 2017

0 references

Yong Huang

1

1 reference

29 July 2017

LE-Ping Li

series ordinal

2

1 reference

29 July 2017

publication date

5 June 2014

1 reference

29 July 2017

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29 July 2017

volume

8

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29 July 2017

issue

2

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29 July 2017

page(s)

493-501

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The Cancer Genome Atlas Pan-Cancer analysis project

29 July 2017

cites work

1 reference

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Drug resistance mediated by AEG-1/MTDH/LYRIC.

28 July 2018

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Pleiotropic roles of AEG-1/MTDH/LYRIC in breast cancer

28 July 2018

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AEG-1/MTDH/LYRIC: clinical significance

28 July 2018

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AEG-1/MTDH/LYRIC, the beginning: initial cloning, structure, expression profile, and regulation of expression

28 July 2018

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Overexpression of astrocyte-elevated gene-1 is associated with cervical carcinoma progression and angiogenesis

28 July 2018

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AEG-1 participates in TGF-beta1-induced EMT through p38 MAPK activation

28 July 2018

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Metadherin confers chemoresistance of cervical cancer cells by inducing autophagy and activating ERK/NF-κB pathway

28 July 2018

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Metadherin is a prognostic predictor of hepatocellular carcinoma after curative hepatectomy

28 July 2018

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Ursolic acid inhibits epithelial-mesenchymal transition by suppressing the expression of astrocyte-elevated gene-1 in human nonsmall cell lung cancer A549 cells.

28 July 2018

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MiR-30d induces apoptosis and is regulated by the Akt/FOXO pathway in renal cell carcinoma

28 July 2018

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Increased expression of metadherin protein predicts worse disease-free and overall survival in laryngeal squamous cell carcinoma

28 July 2018

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Inhibition of Hypoxia Inducible Factor Alpha and Astrocyte-Elevated Gene-1 Mediates Cryptotanshinone Exerted Antitumor Activity in Hypoxic PC-3 Cells

28 July 2018

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The MTDH (-470G>A) polymorphism is associated with ovarian cancer susceptibility

28 July 2018

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Establishment and characterization of MTDH knockdown by artificial MicroRNA interference - functions as a potential tumor suppressor in breast cancer

28 July 2018

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Serum anti-AEG-1 auto-antibody is a potential novel biomarker for malignant tumors

28 July 2018

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Metadherin contributes to the pathogenesis of diffuse large B-cell lymphoma

28 July 2018

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Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model

28 July 2018

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Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon cancer cell lines

28 July 2018

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Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer

28 July 2018

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Astrocyte elevated gene-1 interacts with β-catenin and increases migration and invasion of colorectal carcinoma

28 July 2018

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Metadherin regulates radioresistance in cervical cancer cells.

28 July 2018

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Astrocyte elevated gene-1 induces breast cancer proliferation and invasion through upregulating HER2/neu expression.

28 July 2018

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Inhibition of metadherin sensitizes breast cancer cells to AZD6244.

28 July 2018

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Overexpression of astrocyte-elevated gene-1 is closely correlated with poor prognosis in human non-small cell lung cancer and mediates its metastasis through up-regulation of matrix metalloproteinase-9 expression

28 July 2018

1 reference

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Metadherin mediates lipopolysaccharide-induced migration and invasion of breast cancer cells

28 July 2018

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Metadherin promotes hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition

28 July 2018

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Insulin-like growth factor-binding protein-7 functions as a potential tumor suppressor in hepatocellular carcinoma

28 July 2018

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Oncogene AEG-1 promotes glioma-induced neurodegeneration by increasing glutamate excitotoxicity

28 July 2018

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Oncogenic roles of astrocyte elevated gene-1 (AEG-1) in osteosarcoma progression and prognosis

28 July 2018

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Identification of staphylococcal nuclease domain-containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions

28 July 2018

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Identification of novel variants of metadherin in breast cancer

28 July 2018

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MTDH/AEG-1-based DNA vaccine suppresses lung metastasis and enhances chemosensitivity to doxorubicin in breast cancer

28 July 2018

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Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition.

28 July 2018

1 reference

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Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology

28 July 2018

1 reference

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Astrocyte elevated gene-1 induces protective autophagy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Astrocyte-elevated gene-1 (AEG-1) induction by hypoxia and glucose deprivation in glioblastoma.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Overexpression of AEG-1 in renal cell carcinoma and its correlation with tumor nuclear grade and progression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Molecular mechanism of chemoresistance by astrocyte elevated gene-1.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Astrocyte elevated gene-1: a novel target for human glioma therapy.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Astrocyte elevated gene-1: far more than just a gene regulated in astrocytes.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Astrocyte elevated gene-1 (AEG-1) is induced by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and regulates TLR4 signalling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

The multifaceted role of MTDH/AEG-1 in cancer progression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Identification of genes conferring resistance to 5-fluorouracil

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Knockdown of astrocyte elevated gene-1 inhibits proliferation and enhancing chemo-sensitivity to cisplatin or doxorubicin in neuroblastoma cells

28 July 2018

1 reference

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MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer

28 July 2018

1 reference

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Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1

28 July 2018

1 reference

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Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity

28 July 2018

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Cancer metastasis: building a framework

28 July 2018

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Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc

28 July 2018

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Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy

28 July 2018

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Evidence-based gallbladder cancer staging: changing cancer staging by analysis of data from the National Cancer Database

28 July 2018

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Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis

28 July 2018

1 reference

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Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells

28 July 2018

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3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus

28 July 2018

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28 July 2018

The Hallmarks of Cancer

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AEG-1/MTDH/LYRIC: signaling pathways, downstream genes, interacting proteins, and regulation of tumor angiogenesis

28 July 2018

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MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin

29 October 2018

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[Effect of silencing AEG-1 with small interfering RNA on the proliferation and cell cycle of gastric carcinoma SGC-7901 cells].

29 October 2018

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Expression of AEG-1 and p53 and their clinicopathological significance in malignant lesions of renal cell carcinomas: a microarray study

29 October 2018

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AEG-1 overexpression is essential for maintenance of malignant state in human AML cells via up-regulation of Akt1 mediated by AURKA activation.

29 October 2018

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Astrocyte elevated gene-1 regulates osteosarcoma cell invasion and chemoresistance via endothelin-1/endothelin A receptor signaling

29 October 2018

1 reference

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The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in breast cancer

29 October 2018

1 reference

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AEG-1 expression characteristics in human non-small cell lung cancer and its relationship with apoptosis

29 October 2018

1 reference

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Prognostic impact of Metadherin-SND1 interaction in colon cancer

29 October 2018

1 reference

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Deregulation of MTDH gene expression in gastric cancer.

29 October 2018

1 reference

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Overexpression of metadherin/MTDH is associated with an aggressive phenotype and a poor prognosis in invasive breast cancer.

29 October 2018

1 reference

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Astrocyte elevated gene-1 regulates astrocyte responses to neural injury: implications for reactive astrogliosis and neurodegeneration

29 October 2018

1 reference

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Expression of metadherin/AEG-1 gene is positively related to orientation chemotaxis and adhesion of human hepatocellular carcinoma cell lines of different metastatic potentials

29 October 2018

1 reference

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Prognostic significance of metadherin overexpression in hepatitis B virus-related hepatocellular carcinoma

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Clinical implications of AEG-1 in liver metastasis of colorectal cancer.

29 October 2018

1 reference

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[Expression of EphA7 and MTDH and clinicopathological significance in the squamous cell cancer of the tongue].

29 October 2018

1 reference

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Exposure to cadmium chloride influences astrocyte-elevated gene-1 (AEG-1) expression in MDA-MB231 human breast cancer cells

29 October 2018

1 reference

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MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Prognostic value of the 7th edition of the AJCC staging system as a clinical staging system in patients with hepatocellular carcinoma.

29 October 2018

1 reference

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Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma

29 October 2018

1 reference

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Hallmarks of Cancer: The Next Generation

29 October 2018

1 reference

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Evaluation of the Seventh American Joint Committee on Cancer/International Union Against Cancer Classification of gastric adenocarcinoma in comparison with the sixth classification

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Over-expression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling

29 October 2018

1 reference

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Astrocyte elevated gene-1: recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration

29 October 2018

1 reference

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Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Metadherin, a cell surface protein in breast tumors that mediates lung metastasis

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081432

The metastasis problem gets stickier

29 October 2018

1 reference

12 December 2020

Elevated expression of astrocyte elevated gene-1 (AEG-1) is correlated with cisplatin-based chemoresistance and shortened outcome in patients with stages III-IV serous ovarian carcinoma

1 reference

12 December 2020

Significance of AEG-1 expression in correlation with VEGF, microvessel density and clinicopathological characteristics in triple-negative breast cancer

1 reference

12 December 2020

Astrocyte elevated gene-1 overexpression in human primary gallbladder carcinomas: an unfavorable and independent prognostic factor

1 reference

12 December 2020

AEG -1 overexpression: a novel indicator for peritoneal dissemination and lymph node metastasis in epithelial ovarian cancers

1 reference

12 December 2020

Identifiers

DOI

10.3892/OL.2014.2231

1 reference

29 July 2017

1 reference

29 July 2017

1 reference