Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl. (Q46975253)

27 December 2017

title

Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl. (English)

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27 December 2017

author name string

Jianmin Sun

1

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27 December 2017

Malin Pedersen

2

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27 December 2017

Susanne Bengtsson

3

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27 December 2017

Lars Rönnstrand

4

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27 December 2017

language of work or name

English

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publication date

4 September 2007

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27 December 2017

Experimental Cell Research

published in

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27 December 2017

volume

313

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27 December 2017

issue

18

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27 December 2017

page(s)

3935-3942

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27 December 2017

Signal transduction via the stem cell factor receptor/c-Kit

cites work

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Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1

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Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C.

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Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl).

7 January 2021

1 reference

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Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation.

7 January 2021

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Negative regulation of PTK signalling by Cbl proteins

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The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor

7 January 2021

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Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

7 January 2021

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The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells

7 January 2021

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Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins

7 January 2021

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Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

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A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling

7 January 2021

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c-Cbl is a critical modulator of the Ron tyrosine kinase receptor

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Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation

7 January 2021

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Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction

7 January 2021

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Src family kinases are involved in the differential signaling from two splice forms of c-Kit

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Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor

7 January 2021

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The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit

7 January 2021

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Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

7 January 2021

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Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

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Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation

7 January 2021

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7 January 2021

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Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)

7 January 2021

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Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases

7 January 2021

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7 January 2021

Identifiers

DOI

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27 December 2017

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27 December 2017