Drosophila nicastrin is essential for the intramembranous cleavage of notch (Q41473368)

1 October 2017

title

Drosophila nicastrin is essential for the intramembranous cleavage of notch (English)

1 reference

1 October 2017

0 references

Nicastrin Dmel_CG7012

1 reference

GOA release 2020-03-11

Presenilin Dmel_CG18803

1 reference

GOA release 2020-03-11

author name string

Hernán López-Schier

series ordinal

1

1 reference

1 October 2017

Daniel St Johnston

series ordinal

2

1 reference

1 October 2017

language of work or name

English

0 references

publication date

1 January 2002

1 reference

1 October 2017

number of pages

11

1 reference

inferred from page(s)

published in

Developmental Cell

1 reference

1 October 2017

volume

2

1 reference

1 October 2017

issue

1

1 reference

1 October 2017

page(s)

79-89

1 reference

Presenilins: molecular switches between proteolysis and signal transduction

1 October 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Notch signaling: cell fate control and signal integration in development

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Alzheimer's disease: neurodevelopment converges with neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Drosophila spectrin. II. Conserved features of the alpha-subunit are revealed by analysis of cDNA clones and fusion proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Nicastrin binds to membrane-tethered Notch

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Segregation of two spectrin isoforms: polarized membrane-binding sites direct polarized membrane skeleton assembly

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Synergy between suppressor of Hairless and Notch in regulation of Enhancer of split m gamma and m delta expression

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Presenilin structure, function and role in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Presenilins as therapeutic targets for the treatment of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

LIN-12/Notch signaling: lessons from worms and flies

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Signalling downstream of activated mammalian Notch

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Subcellular localization of presenilins: association with a unique membrane pool in cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

A common enzyme connects notch signaling and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

The Drosophila SHC adaptor protein is required for signaling by a subset of receptor tyrosine kinases.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

A rapid method to map mutations in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Presenilin affects arm/beta-catenin localization and function in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Regulation of APP cleavage by alpha-, beta- and gamma-secretases

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

A Drosophila homolog of cadherin associated with armadillo and essential for embryonic cell-cell adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Characterization and cloning of fasciclin III: a glycoprotein expressed on a subset of neurons and axon pathways in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Evidence for a physical interaction between presenilin and Notch

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Alpha-spectrins are major ubiquitinated proteins in rat hippocampal neurons and components of ubiquitinated inclusions in neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Presenilin, Notch, and the genesis and treatment of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Nuclear access and action of notch in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Spectrin: the ghost in the machine

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Apical spectrin is essential for epithelial morphogenesis but not apicobasal polarity in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

Subcellular distribution and turnover of presenilins in transfected cells

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900109-5

7 January 2021

10.1016/S1534-5807(01)00109-5

Identifiers

DOI

1 reference

1 October 2017

1 reference