Hypericin (Q77509624)

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Hypericin is an anthraquinone derivative that is naturally found in the yellow flower of Hypericum perforatum (St. John's wort) with antidepressant, potential antiviral, antineoplastic and immunostimulating activities
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Hypericin
Hypericin is an anthraquinone derivative that is naturally found in the yellow flower of Hypericum perforatum (St. John's wort) with antidepressant, potential antiviral, antineoplastic and immunostimulating activities

    Statements

    mass
    504.0845174719998 dalton
    1 reference
    based on heuristic
    inferred from InChI
    chemical formula
    C₃₀H₁₆O₈
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    canonical SMILES
    CC1=CC(=O)C2=C(C3=C(C=C(C4=C3C5=C2C1=C6C(=CC(=O)C7=C(C8=C(C=C(C4=C8C5=C67)O)O)O)C)O)O)O
    0 references
    found in taxon
    Hypericum perforatum
    73 references
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    High performance liquid chromatography/electrospray mass spectrometry of Hypericum perforatum extracts
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    Hypericin and Pseudohypericin in Cell Cultures of VariousHypericumSpecies and Chemotypes
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    Characterisation of extracts of Hypericum perforatum L. using an on-line HPLC system with UV/visible and fluorescence detection prior to and after photochemical conversion of the effluent
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    Hypericum perforatum--chemical profiling and quantitative results of St. John's Wort products by an improved high-performance liquid chromatography method
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    Improved procedure for the quality control of Hypericum perforatum L.
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    Quantitative analysis of the active components and the by-products of eight dry extracts of Hypericum perforatum L. (St John's Wort).
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    Fast high-performance liquid chromatographic analysis of naphthodianthrones and phloroglucinols from Hypericum perforatum extracts
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    Sedative activity in mice of a hydroalcohol extract ofHypericum perforatum L.
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    Quantitative evaluation of some species of St. John's wort for their level of hypericins by the HPLC method
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    On the nature of ?soluble? hypericin inHypericum species
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    HPLC-DAD and TLC-Densitometry for quantification of hypericin inHypericum perforatum L. Extracts
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    High-performance liquid chromatographic determination of the biologically active principle hypericin in phytotherapeutic vegetable extracts and alcoholic beverages
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    Hypericin content variation in Hypericum perforatum in Australia
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    Induction of hypericins in Hypericum perforatum in response to chromium
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    Extracts of St. John's wort and various constituents affect beta-adrenergic binding in rat frontal cortex
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    Comparative evaluation of St. John's wort from different Italian regions
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    Evaluation of major active components in St. John's Wort dietary supplements by high-performance liquid chromatography with photodiode array detection and electrospray mass spectrometric confirmation
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    Quantitative determination of biologically active constituents in medicinal plant crude extracts by thin-layer chromatography—densitometry
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    Identification by high-performance liquid chromatography–diode array detection–mass spectrometry and quantification by high-performance liquid chromatography–UV absorbance detection of active constituents of Hypericum perforatum
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    Pressurized liquid extraction of medicinal plants
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    Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models
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    Jasmonic acid-induced hypericin production in cell suspension cultures of Hypericum perforatum L. (St. John's wort).
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    Stimulation of the production of hypericins by mannan in Hypericum perforatum shoot cultures
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    The content of hypericins and phloroglucinols in Hypericum perforatum L. seedlings at early stage of development
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    Hypericin and pseudohypericin in some Hypericum species
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    Hypericum perforatum L. - chemotype without rutin from Italy
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    Determination of hypericin and pseudohypericin in pharmaceutical preparations by liquid chromatography with fluorescence detection
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    High performance liquid chromatographic analysis of St. John's wort with photodiode array detection.
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    Determination of naphthodianthrones in plant extracts from Hypericum perforatum L. by liquid chromatography-electrospray mass spectrometry
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    Evaluation of chemical stability of St. John's wort commercial extract and some preparations
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    Development of a simple, rapid and reproducible HPLC assay for the simultaneous determination of hypericins and stabilized hyperforin in commercial St. John's wort preparations
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    Separation of hypericins and hyperforins in extracts of Hypericum perforatum L. using non-aqueous capillary electrophoresis with reversed electro-osmotic flow
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    Influence of nitrogen on the production of hypericins by St. John’s wort
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    Differential effects of light and nitrogen on production of hypericins and leaf glands in Hypericum perforatum
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    Comparison of German St. John's wort products according to hyperforin and total hypericin content.
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    Pseudohypericin and hypericin in St. John's wort extracts. Breakdown of pseudohypericin
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    High-Performance Liquid Chromatography On-Line Coupled to High-Field NMR and Mass Spectrometry for Structure Elucidation of Constituents ofHypericum perforatumL.
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    Biochemical activities of extracts from Hypericum perforatum L. 5th communication: dopamine-beta-hydroxylase-product quantification by HPLC and inhibition by hypericins and flavonoids.
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    Quantitative changes of dianthrones, hyperforin and flavonoids content in the flower ontogenesis of Hypericum perforatum
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    Effect of light on hypericins contents in fresh flowering top parts and in an extract of St. John's Wort (Hypericum perforatum).
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    Phenolic compounds from Hypericum perforatum
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    Hypericum perforatum subspecies angustifolium shows a protective activity on the consequences of unavoidable stress exposure at lower doses than Hypericum perforatum perforatum.
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    Effect of acute drought stress and time of harvest on phytochemistry and dry weight of St. John's wort leaves and flowers
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    Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test
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    Significance of genetic and environmental aspects in the field cultivation of Hypericum perforatum
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    Production of hypericin, pseudohypericin and flavonoids in cell cultures of various Hypericum species and their chemotypes
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    Effects of Visible and Ultraviolet Light on the Production of Hypericins and Flavonoids in Cell Cultures ofHypericum perforatum
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    Quantitative phytochemical analyses of six hypericum species growing in slovenia
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    Analysis and stability of Hyperici oleum
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    Initiation of Shoot Organ Cultures ofHypericum perforatumand Formation of Hypericin Derivatives
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    Hyperforin, possibly the major non-nitrogenous secondary metabolite of Hypericum perforatum L
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    Antidepressant activity of hypericum perforatum and hyperforin: the neglected possibility
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    Effects of a methanolic extract and a hyperforin-enriched CO2 extract of St. John's Wort (Hypericum perforatum) on intracerebral field potentials in the freely moving rat (Tele-Stereo-EEG).
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    Note Variations in Hypericin Concentrations in Hypericum perforatum L. and Commercial Products
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    Factors affecting growth of cell suspension cultures of hypericum perforatum L. (St. John's wort) and production of hypericin
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    Determination of Major Constituents in St. John's Wort Under Different Extraction Conditions
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    Comparative chemical composition and variability of biological activity of methanolic extracts from Hypericum perforatum L.
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    RAPID ISOCRATIC HPLC ANALYSIS OF HYPERICINS
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    THE DEVELOPMENT AND EVALUATION OF AN HPLC-DAD METHOD FOR THE ANALYSIS OF THE PHENOLIC FRACTIONS FROM IN VIVO AND IN VITRO BIOMASS OF HYPERICUM SPECIES
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    Determining hyperforin and hypericin content in eight brands of St. John's wort.
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    Simultaneous Determination of the Predominant Hyperforins and Hypericins in St. John's Wort (Hypericum perforatum L.) by Liquid Chromatography
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    Determination of St. John's Wort Components in Dietary Supplements and Functional Foods by Liquid Chromatography
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    In vitro and in vivo activation of hypericin with the incoherent light source PDT 1200 SOA (520-750 nm) and with solar simulated radiation (290-2500 nm).
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    Regional differences in hypericin and pseudohypericin concentrations and five morphological traits among Hypericum perforatum plants in the northwestern United States
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    The spectral properties of Hypericum perforatum leaves: the implications for its photoactivated defences
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    Pharmaceutical quality of hypericum extracts
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    Pharmacokinetics of Hypericin and Pseudohypericin after Oral Intake of the Hypericum Perforatum Extract LI 160 in Healthy Volunteers
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    Ontogenetic Variation Regarding Hypericin and Hyperforin Levels in Four Accessions ofHypericum perforatumL.
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    Variation in Hypericins from Wild Populations of Hypericum perforatum L. in the Pacific Northwest of the U.S.A1
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    The analysis of the kinetics of extraction of resinoids and hypericines from the amber, Hypericum perforatum L
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    Hypericin content of Nova Scotia biotypes of Hypericum perforatum L.
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    Catalytic inhibition of human DNA topoisomerase IIalpha by hypericin, a naphthodianthrone from St. John's wort (Hypericum perforatum).
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    Cytotoxic activity of Hypericum perforatum L. on K562 erythroleukemic cells: differential effects between methanolic extract and hypericin

    Identifiers

     
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