Wikidata:WikiProject Medicine/Data models/Drug-drug interactions

Drug-drug interactions occur when two or more different pharmaceutical compounds influence the effect one another. This has important implications for pacients taking multiple drugs at the same time and during complex regimes.

On Wikidata, the property to model the subject is significant drug interaction (P769), connecting a compound with another.

This page aims to organize the modeling of qualifiers used to better describe an interaction.

One source of information (this dataset from A reference set of clinically relevant adverse drug-drug interactions (Q123478206)) models the interactions as:

DRUG_1_CONCEPT_NAME	DRUG_2_CONCEPT_NAME	EVENT_CONCEPT_NAME	MDR_CODE	EVENT_SOURCE	ANSM_SEV_LEVEL	MICROMEDEX_SEV_LEVEL	MICROMEDEX_EVID_LEVEL
Bendroflumethiazide	desmopressin	Hyponatraemia	10021036	BNF+Micromedex	Take into consideration	Major	Theoretical

Thus, a possible way of representing the information on Wikidata would be with the following qualifiers.

For sourcing circumstances (P1480), possibililities include hypothetically (Q18603603), probably (Q56644435) and established (Q123505415).

Title	ID	Data type	Description	Examples	Inverse
significant drug interaction with qualifier side effect	P1909	Item	side effect and adverse drug reaction: The possible clinical effect of the interaction between both drugs	bendroflumethiazide <significant drug interaction> desmopressin <side effect> hyponatremia	-
significant drug interaction with qualifier sourcing circumstances	P1480	Item	sourcing circumstance: The degree of evidence for the claim (if available)	bendroflumethiazide <significant drug interaction> desmopressin <sourcing circumstances> hypothetically	-

Wishlist

• A property to relate each compound with the enzyme that metabolizes it in the human body
• A property for severity of the side effect. It would also be usable for plain side effect (P1909) and symptoms and signs (P780) perhaps.