KLF4
外观
Kruppel样因子4(英語:Kruppel-like factor 4,缩写KLF4)或肠富集Krüppel样因子(英語:gut-enriched Krüppel-like factor,缩写GKLF)是锌指转录因子KLF家族的一个成员,后者属于一个较大的SP1样转录因子家族[5][6][7]。KLF4参与細胞增殖、细胞分化、细胞凋亡和体细胞重编程的调节。有证据表明KLF4在包括大腸癌在内的一些癌症中是肿瘤抑制基因[8]。与KLF2类似,它在C端有三个C2H2型锌指[6]。它有两个核定位序列指引它定位于细胞核内[9]。在胚胎幹細胞(ESCs)和間充質幹細胞(MSCs)中KLF4是显示多能化的很好标记。
参考
[编辑]- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000136826 - Ensembl, May 2017
- ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000003032 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Black AR, Black JD, Azizkhan-Clifford J. Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer. Journal of Cellular Physiology. August 2001, 188 (2): 143–60. PMID 11424081. doi:10.1002/jcp.1111.
- ^ 6.0 6.1 Dang DT, Pevsner J, Yang VW. The biology of the mammalian Krüppel-like family of transcription factors. The International Journal of Biochemistry & Cell Biology. November 2000, 32 (11–12): 1103–21. PMC 2754176
. PMID 11137451. doi:10.1016/s1357-2725(00)00059-5.
- ^ Kaczynski J, Cook T, Urrutia R. Sp1- and Krüppel-like transcription factors. Genome Biology. 2003, 4 (2): 206. PMC 151296
. PMID 12620113. doi:10.1186/gb-2003-4-2-206.
- ^ El-Karim EA, Hagos EG, Ghaleb AM, Yu B, Yang VW. Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts. Molecular Cancer. August 2013, 12: 89. PMC 3750599
. PMID 23919723. doi:10.1186/1476-4598-12-89.
- ^ Shields JM, Yang VW. Two potent nuclear localization signals in the gut-enriched Krüppel-like factor define a subfamily of closely related Krüppel proteins. The Journal of Biological Chemistry. July 1997, 272 (29): 18504–7. PMC 2268085
. PMID 9218496. doi:10.1074/jbc.272.29.18504.
外部链接
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